Navigation Links
Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

sed company Maxygen, provides Kao with a second advantage--speed. After one round of generating mutants with transposons, only a handful of the many mutants generated will likely increase antibiotic yields. Shuffling creates combinations of all mutants that originally generated increased yields--similar to genetic recombination--and produces sequences with multiple mutations more quickly.

Think of a genome as a deck of cards, and inducing a beneficial mutation as slipping in a joker. It's easy to see which decks have jokers--or which strains produce more antibiotics. Imagine mixing and then separating ten decks that all have two jokers each. Do it with enough replications and you'll get a deck with 20 jokers--or a bacterium with 20 beneficial mutations.

"In one year we should be able to generate a high producer that's equivalent to 20 years of work with the traditional method, and then we can study the identifiable mutations," Kao said.

Whether she's studying existing mutants or creating her own, Kao's main interest lies in learning how to manipulate cells to do what she wants. The family of soil bacteria she focuses on, the actinomycetes, produces thousands of bioactive molecules, with many more discoveries sure to come.

"When new molecules are discovered to be made by species of this family, the research we do will hopefully be used to quickly make mutant strains that make a lot more of it," she said. "No drug company wants to wait 20 years to release a new antibiotic."


'"/>

Source:Stanford University


Page: 1 2 3 4

Related biology news :

1. Chemicals in tattoo inks need closer scrutiny
2. Roots Engage in Underground Chemical Warfare
3. Chemical band-aid prevents heart failure in mice with muscular dystrophy
4. Chemical compound inhibits tumor growth, size in new mouse study
5. T-rays: New imaging technology spotlighted by American Chemical Society
6. Chemical warfare agent detection technology used to treat lung disease
7. Chemical guidance of T cells leads to immunologic memory and long-term immunity
8. Chemical signaling helps regulate sensory map formation in the brain
9. Chemical in many air fresheners may reduce lung function
10. Chemical tests of cell growth enter third dimension
11. Chemicals in brown algae may protect against skin cancer
Post Your Comments:
(Date:11/7/2014)... Dr. Debra Auguste, associate professor, biomedical engineering, in ... College of New York, have identified a molecule ... of the most aggressive forms of breast cancer. ... high mortality rate owing to aggressive proliferation and ... However, Professor Auguste,s team, discovered the overexpression of ...
(Date:11/7/2014)... Leading Biometric companies aim to provide ... online transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... BABA ), Google Inc. (NASDAQ: GOOG ), Microsoft ... EBAY ) and MasterCard Inc. (NYSE: MA) ... biometric authentication company focused on the growing mobile commerce is ...
(Date:11/6/2014)... because of metastasis, yet progress in preventing and ... "It,s been particularly challenging to design drugs that ... in systems biology at Harvard Medical School. ... they,ve already metastasized." , Gujral and colleagues have ... researchers better understand how metastasis begins. Their findings ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6Migration negation 2Migration negation 3
... Federation of American Societies for Experimental Biology (FASEB) announces ... (SRC): Mobile DNA in Mammalian Genomes. Mobile elements ... the structure and altering functions within mammalian genomes, and ... explore the explosion of data from high throughput sources, ...
... This release is available in French . ... on the brain,s ability to be plastic that is to ... study from the Montreal Neurological Institute The Neuro, McGill University, ... nervous system known as netrin, plays a key role in regulating ...
... defines and names groups of organisms is a ... methods used during the beginnings of the discipline in ... information to delineate new species, the study of the ... of taxonomists. These studies often require first-hand examination of ...
Cached Biology News:Finding the way to memory 2Finding the way to memory 3Biodiversity exploration in the 3-D era 2
(Date:11/21/2014)... York, NY (PRWEB) November 20, 2014 ... is now available as an open access journal featuring ... with infrared fluorescent proteins to preserve photoresponsiveness in the ... Two-color fluorescent in situ hybridization using chromogenic substrates ... chips for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... 21, 2014 Why did Stephen Hawking ... Einstein so instantly recognizable? Why have they become icons ... and author Hilton Ratcliffe seeks out the answers to ... all to do with science. In " Stephen Hawking ... November 21, 2014), Ratcliffe puts it plainly: , ...
(Date:11/21/2014)... Dallas, Texas (PRWEB) November 21, 2014 ... Industry” is a professional and in-depth research report ... information, including its definition, classification, application, and industry ... research covers the international market analysis, including China’s ... covering macroeconomic environment & economic situation analysis. The ...
(Date:11/21/2014)... /CNW/ - Aequus Pharmaceuticals Inc. (the "Company" or ... closed a brokered private placement offering (the "Brokered ... Cormark Securities Inc. and Clarus Securities Inc. acted ... a syndicate of agents that also included Wolverton ... "Agents"). Concurrently with the Brokered Offering, the Company ...
Breaking Biology Technology:BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3
... $1,036,024, or 89%, for the nine months ended September 30, ... ... 26 /Xinhua-PRNewswire-FirstCall/ -- China Kangtai,Cactus Bio-tech Inc. (OTC Bulletin Board: CKGT), a ... filed its quarterly report on SEC Form 10QSB on November,19, 2007 and ...
... Dramatically Enhances the Way Ultrasound, Departments Work and Provides a ... ... Applications, CHICAGO, Nov. 26 At the 93rd Scientific ... from,Nov. 25 to 30 at McCormick Place (Booth 7713, Hall B), ...
... to Integrate with Multiple Disparate PACS and ... ... CHICAGO, Nov. 26 RSNA Booth #5924 -- ... and,interoperability between diagnostic acquisition devices, PACS, HIS, RIS,and related ...
Cached Biology Technology:China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 2China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 3China Kangtai Cactus Biotech, Inc. Reports Third Quarter 2007 Financial Results 4Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 2Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 3Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 4Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 5Siemens' New S Class Revolutionizes the Paradigm of Ultrasound Workflow Today and Tomorrow 6E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 2E-Rad Solutions Selects Compressus' Enterprise Systems Integration Technology to Fuel Entry Into Teleradiology Market 3
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
See product name for description....
5,6 Carboxyfluorescein is conjugated to BSA (bovine serum albumin) protein through amide bonds....
Biology Products: