Navigation Links
Cheap, rapid hand-held check for HIV

Political pressure has finally seen the price of antiretroviral therapy for HIV slashed in poorer countries. But a lack of cheap, simple diagnostics to enable doctors to use these complex treatments remains a stumbling block.

Now scientists from two New York universities believe they have the solution: a hand-held sensor that checks the health of a patient's immune system in seconds. At the moment it can take a week to get the same results back from the lab, "and that's if they don't get lost", says Glenda Gray, a consultant physician and head of perinatal HIV research at the University of the Witwatersrand in Johannesburg, South Africa.

The sensor measures the quantity of key immune cells called CD4+ cells in the blood. A gradual depletion of CD4+ cells, which orchestrate the immune response to tumours and infections, is a sure sign that HIV is damaging a person's health: some clinical definitions of AIDS say that once a person's CD4+ count falls below 200 cells per microlitre of blood, he or she has developed the condition.

Doctors rely on CD4+ measurements to decide when to start drug treatments and to gauge whether a patient is responding to them.

To make the device, researchers from Cornell University in Ithaca and the University at Albany coated electrodes with antibodies specific to CD4+ cells. When a small sample of blood is put onto a chip bearing these electrodes, the antibodies grab hold of the CD4+ cells. The captured cells then impede the flow of current across the electrodes, allowing the density of CD4+ cells to be calculated.

To check that only CD4+ cells were sticking to the electrodes the team added a label to blood samples consisting of a fluorescent dye tagged to a further set of antibodies specific for CD4+ cells. They then used an electron microscope to check which cells had been captured. By counting the captured cells, the researchers devised a scale linking electrical resistance with the density of cells in the blood (Biosensors & Bioelectronics, vol 21, p 696).

"It is the first step towards a hand-held, simple, inexpensive device that will measure the number of CD4+ cells in human blood without the need for extensive infrastructure," says James Turner, a biophysicist at the University at Albany, who led the research.


'"/>

Source:New Scientist Boston office


Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Researchers develop rapid diagnostic tool for pathogen identification
3. Variation in HIVs ability to disable host defenses contributes to rapid evolution
4. New technique rapidly detects illness-causing bacteria
5. NASA satellite data provides rapid analysis of Amazon deforestation
6. Prions rapidly remodel good protein into bad, Brown study shows
7. Customized gene chip provides rapid detection of genetic changes in childrens cancer
8. A bugs life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist
9. Scientists must offer solutions for conserving tropical forests in a rapidly changing world
10. Radiation-armed robot rapidly destroys human lung tumors
11. New strategy rapidly identifies cancer targets
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2017)... About Voice Recognition Biometrics Voice recognition biometrics ... a stored voiceprint template. Acoustic features of an ... are compared to distinguish between individual voices. Voice ... PCs already have a microphone and can authenticate ... are most likely to be deployed in telephone-based ...
(Date:2/7/2017)...   MedNet Solutions , an innovative SaaS-based eClinical ... research, is pleased to announce that the latest release ... flexible and award winning eClinical solution, is now available ... is a proven Software-as-a-Service (SaaS) clinical research technology platform ... also delivers an entire suite of eClinical tools to ...
(Date:2/3/2017)... 2017 A new independent identity strategy consultancy ... (IdSP) . Designed to fill a critical niche in ... founding partners Mark Crego and Janice ... in identity expertise that span federal governments, the 9/11 ... Crego-Kephart combined expertise has a common theme born from ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... Atlanta, it seems everyone has a chance to express their ... expressive and dynamic community unlike any other. The businesses that ... With their newest salon in ... on that tradition with a unique, fresh approach to head ... the newest of 13 nationwide locations, each of them well-situated ...
(Date:2/23/2017)... ... February 23, 2017 , ... ... in a published evaluation of multiple immunoassay-based threat detection technologies by researchers ... Laboratory, PathSensors’ CANARY® biosensor threat detection technology was found to have the ...
(Date:2/23/2017)...  Capricor Therapeutics, Inc. (NASDAQ: CAPR), a biotechnology company developing ... that Linda Marbán, Ph.D, president and chief executive officer, is ... Cowen and Company 37th Annual Health Care Conference ... Boston, MA 29th Annual ROTH ... pm ET) Dana Point, CA ...
(Date:2/22/2017)... 2017  Aratana Therapeutics, Inc. (NASDAQ: PETX), a pet therapeutics ... biopharmaceutical products for companion animals, will host a live conference ... to discuss financial results from the fourth quarter and full ... and investors may access the audio webcast or ... ...
Breaking Biology Technology: