Navigation Links
Cheap, rapid hand-held check for HIV

Political pressure has finally seen the price of antiretroviral therapy for HIV slashed in poorer countries. But a lack of cheap, simple diagnostics to enable doctors to use these complex treatments remains a stumbling block.

Now scientists from two New York universities believe they have the solution: a hand-held sensor that checks the health of a patient's immune system in seconds. At the moment it can take a week to get the same results back from the lab, "and that's if they don't get lost", says Glenda Gray, a consultant physician and head of perinatal HIV research at the University of the Witwatersrand in Johannesburg, South Africa.

The sensor measures the quantity of key immune cells called CD4+ cells in the blood. A gradual depletion of CD4+ cells, which orchestrate the immune response to tumours and infections, is a sure sign that HIV is damaging a person's health: some clinical definitions of AIDS say that once a person's CD4+ count falls below 200 cells per microlitre of blood, he or she has developed the condition.

Doctors rely on CD4+ measurements to decide when to start drug treatments and to gauge whether a patient is responding to them.

To make the device, researchers from Cornell University in Ithaca and the University at Albany coated electrodes with antibodies specific to CD4+ cells. When a small sample of blood is put onto a chip bearing these electrodes, the antibodies grab hold of the CD4+ cells. The captured cells then impede the flow of current across the electrodes, allowing the density of CD4+ cells to be calculated.

To check that only CD4+ cells were sticking to the electrodes the team added a label to blood samples consisting of a fluorescent dye tagged to a further set of antibodies specific for CD4+ cells. They then used an electron microscope to check which cells had been captured. By counting the captured cells, the researchers devised a scale linking electrical resistance with the density of cells in the blood (Biosensors & Bioelectronics, vol 21, p 696).

"It is the first step towards a hand-held, simple, inexpensive device that will measure the number of CD4+ cells in human blood without the need for extensive infrastructure," says James Turner, a biophysicist at the University at Albany, who led the research.


'"/>

Source:New Scientist Boston office


Related biology news :

1. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
2. Researchers develop rapid diagnostic tool for pathogen identification
3. Variation in HIVs ability to disable host defenses contributes to rapid evolution
4. New technique rapidly detects illness-causing bacteria
5. NASA satellite data provides rapid analysis of Amazon deforestation
6. Prions rapidly remodel good protein into bad, Brown study shows
7. Customized gene chip provides rapid detection of genetic changes in childrens cancer
8. A bugs life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist
9. Scientists must offer solutions for conserving tropical forests in a rapidly changing world
10. Radiation-armed robot rapidly destroys human lung tumors
11. New strategy rapidly identifies cancer targets
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems is ... log work hours, for employers to make sure the right employees are actually signing ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... The Department of Transport Management (DOTM) of ... project, for the , Supply and Delivery of ... Infrastructure , to Decatur , ... Management Solutions. Numerous renowned international vendors participated in the tendering ... selected for the most compliant and innovative solution. The contract ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) ... precise treatments and faster cures for prostate cancer. Members of the Class of ... 15 countries. Read More About the Class of 2016 ... ... ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
(Date:6/23/2016)... OTTAWA, ON (PRWEB) , ... June 23, 2016 , ... ... former DNA Technical Leader at the Arkansas State Crime Laboratory, has joined STACS DNA ... joining the STACS DNA team,” said Jocelyn Tremblay, President and COO of STACS DNA. ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: