Navigation Links
Changes in amino acids in the 1918 influenza virus cut transmission

Modest changes in the 1918 flu virus's hemagglutinin receptor binding site—a molecular structure critical for the spread of infection—stopped viral transmission in ferrets, according to a new study conducted by researchers at Mount Sinai School of Medicine and at the Centers for Disease Control and Prevention. The finding, published in the February 1 issue of Science, could have significant clinical implications in helping scientists develop ways to break the disease cycle and possibly help reduce the risk for a potential pandemic.

While flu pandemics occur every 10 to 40 years, the factors that lead to the emergence of pandemic viruses are not well understood, explains study co-author Adolfo García-Sastre, PhD, Professor of Microbiology at Mount Sinai School of Medicine. "What's most threatening is the possibility of another pandemic, similar to that of 1918, which was caused by a novel influenza subtype virus capable of causing severe respiratory disease and death," says Dr. García-Sastre. "So if we can understand the molecular mechanisms behind its transmission, perhaps we can do something to block transmission and prevent illness."

To do this, Dr. García-Sastre and his team studied two key molecular structures: hemagglutinin, a protein located in of the surface of the influenza virus, and sialic acid, a cellular molecule that is recognized by hemaglutinins of both human and avian strains of influenza virus. These molecules are key to initiation of infection. There are 16 different subtypes of hemagglutinin called H1 through H16, present in influenza virus strains circulating in birds. H1 and H3 are found today in human influenza viruses.

Hemaglutinin helps open the door to the cell to allow the virus to infect. The first step is in this process is the binding of the hemagglutinin to sialic acid containing molecules in the cell surface. There are two primary ways sialic acids are associated with molecules in the cell surface—one is th
'"/>

Source:The Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1 2 3

Related biology news :

1. Iron Deficiency Sparks Dramatic Changes In Gene Expression
2. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
3. FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
4. Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
5. Changes to embryos can elicit change in adult fish
6. Conserved amino acids play both structural and mechanistic roles in sandwich-like protein
7. New technique helps researchers determine amino-acid charge
8. Use of amino acid supplement following a heart attack provides no benefit, may be harmful
9. Amino acids in nectar enhance butterfly fecundity: A long awaited link
10. Researchers create pigs that produce heart-healthy omega-3 fatty acids
11. Computers to be used to find blueprint for new influenza drug
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Changes amino acids the influenza virus cut transmission

(Date:5/5/2015)... , May 5, 2015, NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, reminds investors ... Chief Technology Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA ... 5-7, 2015. The three-day conference is organized ... is speaking in is themed Global Fraud: Where is ...
(Date:4/27/2015)... FORT LAUDERDALE, Fla. , Apr. 27, 2015 /PRNewswire/ ... provider of access control and security systems is pleased ... joined the company as a consultant and member of ... Bedore is widely known as a thought leader ... Socrates Distance Learning Technology Group, and has published studies ...
(Date:4/20/2015)... 2015 The announcement comes as ... Records Management (GRM), Ireland,s foremost records ... Having built up an impressive track record of clients within ... within the records management sector in Dubai ... GCC staffbase and employ a further eight staff members at ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... 20, 2012   Cell Therapeutics, Inc. ("CTI") (NASDAQ and ... European Medicines Agency,s ("EMA") Committee for Medicinal Products for ... on CTI,s Marketing Authorization Application ("MAA") for Pixuvri in ... with the CHMP on the Summary of Product Characteristics ...
... of scientists has found one of the rarest and least ... was believed to be extinct or on the verge of ... of Primatology , confirms the continued existence of this endangered ... it was previously not known to exist. Miller,s Grizzled ...
... flow channels offer a chemically unique environment, which at first ... in the crust of the earth, through which water flows, ... And yet it is precisely this extreme environment, where ... root of all life: The multiplication of biomolecules (reproduction) and ...
Cached Biology News:Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February 2Cell Therapeutics, Inc. Expects That the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) May Issue an Opinion on the Marketing Authorization Application ("MAA") on Pixuvri™ in Mid-February 3'Extinct' monkey rediscovered in Borneo by new expedition 2Avalanche of reactions at the origin of life 2Avalanche of reactions at the origin of life 3
(Date:5/6/2015)... -- Bone Biologics, Corp., ("Bone Biologics") announced today the completion ... Capital") of Los Angeles, CA. The ... regenerative medicine using the patented recombinant human protein known as ... Michael Schuler , CEO of Bone ... round of funding which will allow the company to continue ...
(Date:5/6/2015)... San Jose, California (PRWEB) May 06, 2015 ... – Quantum Dots, a type of nanomaterial with ... the fastest-growing product in the global nanophotonics materials ... properties of quantum dots due to quantum confinement ... use in a wide range of scientific, technological, ...
(Date:5/6/2015)... -- Oxis Biotech, Inc. (OXIS), a wholly owned subsidiary of ... Cassian Yee , M.D., Professor, Department of Melanoma ... of Texas MD Anderson Cancer Center joined its scientific ... Immunology, Division of Cancer Medicine, and Director, Solid Tumor ... University of Texas MD Anderson Cancer Center.  ...
(Date:5/6/2015)... , May 6, 2015 Dr Jaspreet ... Massey University, will deliver a speech at the 2015 Asian ... the Shanghai New Expo Center.  ... introduce to attendees the topic: ,Potato Starch: A Potential ... Smart Foods., Co-editor of a 528 page ...
Breaking Biology Technology:Bone Biologics Corp Completes Financing With Hankey Capital, LLC 2Bone Biologics Corp Completes Financing With Hankey Capital, LLC 3Expanding Applications & Full-Scale Commercialization to Drive the Global Quantum Dots Market, According to a New Report by Global Industry Analysts, Inc. 2Expanding Applications & Full-Scale Commercialization to Drive the Global Quantum Dots Market, According to a New Report by Global Industry Analysts, Inc. 3Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 2Oxis Biotech Appoints Cassian Yee, M.D. To Its Scientific Advisory Board 3Potato Starch: A Potential Source for the Creation of Next Generation Bulk-ingredients and Smart Foods 2
... asking for bids on the construction of downtown wireless Internet access ... to charge user fees and would take on the cost of ... for the right to operate. The project would not be paid ... costs are still not finalized. , ,Now, though, the city is ...
... Wis. While the Madison chapter of the ... for new social and technological developments, Scott Converse showed them ... they want to see where the next big thing is ... UW-Madison School of Business and founder of the Web integration ...
... is full of excitement and anticipation of what may await them ... screen the final onslaught of companies vying for a place at ... February to unwrap the selected 70 or so companies that will ... way that just wont wait until the conference gems we ...
Cached Biology Technology:Madison asks for wireless bids; airport, downtown would be first 2Business-school IT director points to reasons for wireless trend 2An early Christmas gift 2
... is the only PCR system that ensures ... time. It provides accuracy, consistency, and dependability ... the property of the DNA templates. This ... a unique blend of thermostable enzymes that ...
Special grade: for molecular biology Density: 1.000 g/mL (20 C)...
... meet the needs of the ... medium supports fast cell growth ... while maintaining high cell viability ... using the Baculovirus Expression Vector ...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z36,327-8) or contact ...
Biology Products: