Navigation Links
Change in gene may be underlying molecular defect in some colorectal cancers

Inactivation of a DNA repair gene may be an early step in the development of sporadic colorectal tumors, and detection of the molecular basis for this inactivation may ultimately be useful in risk assessment for colorectal cancer, according to a new study in the September 21 issue of the Journal of the National Cancer Institute.

Cancers can arise from a region of cells with a "field defect", cells that appear normal but that have an underlying molecular defect. The molecular basis for the field defect is easy to understand when tumors develop from cells that all have similar genetic abnormalities, such as those that occur in patients who are genetically predisposed to a cancer or those who undergo an exposure to a carcinogen such as tobacco smoke. However, how the field defect may arise in most sporadic cancers in unclear.

In colorectal cancer, the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) is often methylated--that is, the gene's promoter region has methyl groups added to it, which inactivate the gene. Jean-Pierre J. Issa, M.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues hypothesized that MGMT promoter methylation could be one of the characteristics of the field defect in colorectal cancer, so they studied MGMT promoter methylation in the tumor, adjacent mucosa, and nonadjacent mucosa of 95 colorectal cancer patients and in the colon mucosa of 33 subjects without cancer.

MGMT promoter methylation was found in 50% to 94% of colorectal tumors, depending on the method of detection, and normal-appearing colon mucosa up to 10 cm away from the tumor had detectable MGMT methylation. In addition, the authors detected MGMT methylation in the normal colon mucosa of several subjects who did not have cancer.

"Because a loss of MGMT protein function is a plausible predisposing factor for cancer through the increased occurrence of mutations? our data indicate that MGMT pro
'"/>

Source:Journal of the National Cancer Institute


Page: 1 2

Related biology news :

1. Iron Deficiency Sparks Dramatic Changes In Gene Expression
2. Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower
3. FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
4. Some Brain Cells Change Channels To Fine-tune The Message
5. Some Brain Cells Change Channels
6. Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
7. Is it Possible to Change Prescribing Habits?
8. Changes to embryos can elicit change in adult fish
9. Changes in amino acids in the 1918 influenza virus cut transmission
10. New mechanism underlying pain found
11. Revealing the machinery underlying the plastic juvenile brain
Post Your Comments:
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
(Date:3/30/2015)... and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has announced ... in Automotive Sector 2014-2018" report to their offering. ... market in Automotive Sector to grow at a CAGR ... recognition is the ability of a device to identify ... recognition technology can be 2D-based or 3D-based. It uses ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2
... 27, 2011 Scientists at The Scripps Research Institute have ... cells of schizophrenic subjects. The findings suggest that ... hope as a treatment for schizophrenia and related conditions in ... the new Nature journal, Translational Psychiatry , ...
... mining precious metals. But scientists Dennis Bazylinski and colleagues ... different type of mining. They sluice through every water ... magnetism. In a basin named Badwater on the edge ... hit pay dirt. Lefvre is with the French National ...
... PROVIDENCE, R.I. -- History often seems to happen in ... decade and empires give way to new ones over ... years of natural history in North America, where a ... of mammal species diversity, or "evolutionary faunas." What force ...
Cached Biology News:Scripps Research scientists discover a brain cell malfunction in schizophrenia 2Scripps Research scientists discover a brain cell malfunction in schizophrenia 3Scripps Research scientists discover a brain cell malfunction in schizophrenia 4Badwater Basin: Death Valley microbe thrives there 2Over 65 million years North American mammal evolution has tracked with climate change 2
(Date:4/24/2015)... Seoul Semiconductor announced the expansion of its ... lighting market. In recent months, there have ... emerging markets such as Russia, South America, and ... such as streetlight and area lighting, tunnel lighting, ... in 2005 the Acrich technology from Seoul Semiconductor ...
(Date:4/23/2015)... Athena San Diego, an organization that accelerates ... San Diego’s technology and life science sectors, will announce ... their Gala on April 30, 2015 from 5-9pm at ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals and ... of fostering networking, risk taking and diversity of thought, ...
(Date:4/23/2015)... , April 23, 2015 /CNW/ - A new ... packaging award from North America,s ... Competitor Comparison won Silver in the "Sustainability, service" ... The Brandcheck "Competitor Comparison" is a service ... North American and Global peers. This benchmarking process ...
(Date:4/23/2015)... Six startups from Russia traveled to ... part of the U.S.-Russia Innovation Corridor (USRIC) program. ... startups to participate in the program since the ... University of Maryland (UMD) signed a Memorandum of ... in the biomedical industry in 2013. , Supported ...
Breaking Biology Technology:Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4
... Sept. 17 Synvista,Therapeutics, Inc. (Amex: SYI ) ... to the Company,s Web site http://www.synvista.com . The,text ... team at Synvista Therapeutics has made tremendous progress in ... and to redefine,the treatment of cardiovascular disease in diabetics ...
... Sigma-Aldrich Corporation,(Nasdaq: SIAL ) will be presenting ... September 24th at 8:30 AM ET at the Grand ... live audio broadcast over the,Internet available at http://ir.sigmaaldrich.com ... file. For the webcast on, http://ir.sigmaaldrich.com users will ...
... Alfacell Corporation,(Nasdaq: ACEL ) announced today ... of Oppenheimer & Co. as a financial advisor ... alternatives to enhance,shareholder value, including a possible sale ... not be limited to, strategic partnership,transactions., "Alfacell ...
Cached Biology Technology:Synvista Therapeutics Posts Letter to Stockholders on Web Site 2Synvista Therapeutics Posts Letter to Stockholders on Web Site 3Synvista Therapeutics Posts Letter to Stockholders on Web Site 4Synvista Therapeutics Posts Letter to Stockholders on Web Site 5Synvista Therapeutics Posts Letter to Stockholders on Web Site 6Alfacell Hires Advisors to Advance Strategic Alternatives 2Alfacell Hires Advisors to Advance Strategic Alternatives 3
... designed for paramagnetic bead precipitation from standard ... plates with no additional accessories. The stand ... standard SBS 96-well microplate footprint. The use ... easy and fast (as little as 30 ...
... to create the ideal environment for nucleic acid ... , Variable speed control (10 to 15 ... be for washing or hybridizing , A ... the chamber, ,is situated above a touch sensitive ...
... based purification systems provide high speed purification ... They offer increased throughput and reproducible results. ... KingFisher mL and KingFisher 96, covering sample ... system consists of an instrument, specially designed ...
... Savant SpeedVac Concentrators set the standard for centrifugal ... uses a combination of centrifugal force, heat and ... run., SC110A comes equipped with:, , TEFLON-coated ... , Three ...
Biology Products: