Navigation Links
Cellular traffic backups implicated in skeletal malformations

A defective link in the intracellular protein "transit system" may lie at the heart of some craniofacial defects, new research in zebrafish suggests.

In the Sept. 17 online issue of Nature Genetics, Vanderbilt University Medical Center researchers report the identification of a mutation that causes severe skeletal deformities in zebrafish by shutting down a critical protein transport pathway.

The findings are surprising, said Ela Knapik, M.D., lead investigator on the study, because this pathway is thought to be so universal that a defect would prove fatal just hours after fertilization. But the mutant fish, named crusher, hatched and survived to nine days, albeit with striking skeletal abnormalities ?craniofacial defects, kinked fins and shortened body.

The pathway affected by the crusher mutation is key to transporting proteins outside of the cell. All proteins are made in the endoplasmic reticulum (ER), a labyrinthine compartment just outside the cell's nucleus. Proteins are then "packaged" into transport containers called vesicles, which traverse the gelatinous cytoplasm of the cell's interior. The vesicles eventually dock with the Golgi, a structure that resembles a pancake stack and is the last major "transit station" of the cell. In the Golgi, proteins are modified into their active, final form before being shipped out to the surface of the cell in another type of vesicle. Once they reach their destination, the proteins either empty out into the extracellular space or take up residence in the cell membrane.

"Protein transport and secretion is a fundamental function of every living cell, in every organism," said Knapik, associate professor of Medicine and Cell and Developmental Biology. Similar mutations in yeast and cultured cells were lethal from the start, suggesting that no multicellular animal would be able to survive such a defect.

But, the crusher mutation appears to only affect chondrocytes, the cells th
'"/>

Source:Vanderbilt University Medical Center


Page: 1 2 3

Related biology news :

1. Molecular Motors Cooperate In Moving Cellular Cargo, Study Shows
2. Cellular Defects in Premature Aging Disease are Reversible
3. Cellular scale drug delivery from the inside out
4. Cellular antennae on algae give clues to how human cells receive signals
5. Neuronal traffic jam marks early Alzheimers disease
6. Discovery of T-cell traffic control boosts new drug promise
7. Cells direct membrane traffic by channel width
8. Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning
9. The brain, traffic and nano-circuits -- e-Science takes on major challenges
10. Molecular mechanism provides intra-cellular traffic signal
11. New imaging technique tracks traffic patterns of white blood cells
Post Your Comments:
(Date:8/28/2014)... to Research Careers) Program has announced the travel ... Medicine,s Conference on Integrative Physiology of Exercise from ... awards are meant to promote the entry of ... into the mainstream of the basic science community ... at the American College of Sports Medicine,s Conference ...
(Date:8/28/2014)... measuring and imaging how quickly blood flows in the ... drug abuse affects the brain, which may aid in ... better treatment options for recovering drug addicts. The new ... Brook University in New York, USA and the U.S. ... Optical Society,s (OSA) open-access journal Biomedical Optics ...
(Date:8/28/2014)... roads will be built worldwide by 2050. Many of ... they bring an influx of destructive loggers, hunters and ... created a ,global roadmap, for prioritising road building across ... of development and environmental protection. , The map has ... importance of ecosystems and a ,road-benefits, layer that estimates ...
Breaking Biology News(10 mins):This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Study shows where on the planet new roads should and should not go 2Study shows where on the planet new roads should and should not go 3
... New Zealand is marked at approximately 38 S latitude by ... region forms the southern distributional limit of many plants and ... endemic plants are found there. Ecologists have recently discovered a ... line". Wetlands serve vital ecological functions by providing wildlife ...
... types of rice from around the world has found its glycemic index ... scoring a low to medium GI.,This finding is good news because it ... the average consumer, it also means people with diabetes, or at risk ... low GI diet. The study found that the GI of rice ...
... Bovine spongiform encephalopathy (BSE, or "mad cow disease") is a ... to turn sponge-like. This transmissible disease is caused by ... a prion, rather than by a bacterium or virus. ... about 60 months. Little is known about the pathogenesis of ...
Cached Biology News:A new species of wirerush from the wetlands in northern New Zealand 2Study reveals good news about the GI of rice 2Study finds 'mad cow disease' in cattle can spread widely in ANS before detectable in CNS 2
(Date:8/28/2014)... 28, 2014 A new market ... world is available from Strategic Consulting, Inc., the ... Industrial Microbiology Market Review, Fourth Edition: Global Review ... (IMMR—4) tracks and compares microbiology test volumes, market ... Europe and Asia, and forecasts future volumes and ...
(Date:8/28/2014)... 2014 PrimeSource Building Products, Inc., ... SoundConnect to support their communication needs ... and web conferencing platform GlobalMeet powered by SoundConnect. ... needs. SoundConnect delivers award winning “results driven” ... Products will be utilizing GlobalMeet powered by ...
(Date:8/28/2014)... Whitehouse Laboratories is excited to announce that ... PTI Inspection Systems that will enable it to ... leak testing method development and validation programs using the ... part of this agreement, Whitehouse Labs has taken delivery ... developed and manufactured by PTI. The HVLD (high ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3PrimeSource Chooses SoundConnect as Collaboration Provider 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... Bionovo, Inc.,(Nasdaq: BNVI ), a pharmaceutical company focused ... in the areas of women,s health and,cancer, announced today ... presenting at the Canaccord Adams 28th Annual Global Growth ... 8:00 AM ET on,Wednesday, August 13, 2008 at the ...
... p.m. (Pacific); ... http://www.adventrx.com , SAN DIEGO, Aug. 8 ADVENTRX ... host a conference call with,simultaneous webcast to discuss second quarter ... / 4:30 p.m. Eastern. Evan M. Levine,Chief Executive Officer and ...
... State University researchers have made a breakthrough in understanding ... of urban pollution. The discovery could lead to more ... and James Anderson. , Crozier is an associate professor ... by the College of Liberal Arts and Sciences and ...
Cached Biology Technology:Bionovo to Present at Canaccord Adams Global Growth Conference 2Forward step in forecasting global warming 2Forward step in forecasting global warming 3
... Thermocycler provides high speed and excellent temperature ... a TGradient Thermocycler can be run without ... a silver block for 48 or 96 ... plates or in-situ applications are available. The ...
General description: MaxiSorp TM surface is ideal for arraying molecules with mixed hydrophilic/hydrophobic domains such as proteins ID clarifier: Maxisorp(tm) with lid...
... Ideal for staining westerns and includes stickers ... Pour spouts in each corner facilitate pouring ... be used for identification. Lid is designed ... for staining several gels simultaneously. Lid also ...
ID clarifier: non-treated with lid...
Biology Products: