Navigation Links
Cell wall of pneumonia bacteria can cause brain and heart damage

Investigators at St. Jude Children's Research Hospital have discovered in mouse models how cell walls from certain pneumonia-causing bacteria can cause fatal heart damage; researchers have also shown how antibiotic therapy can contribute to this damage by increasing the number of cell wall pieces shed by dying bacteria. The team also demonstrated in a mouse model how to prevent this from happening.

The study shows that pieces of cell walls from Streptococcus pneumoniae bacteria "hijack" a protein on the lining of the blood vessel wall and use it to slip out of the bloodstream and into the brain and heart. A report on this study appears in the November 1 issue of the Journal of Immunology. These findings explain why blood stream infection with S. pneumoniae commonly leads to temporary impairment of heart function, and they suggest a way to prevent that from occurring, according to Elaine Tuomanen, M.D., chair of the St. Jude Department of Infectious Diseases. S. pneumoniae is a leading cause of pneumonia, sepsis (a potentially life-threatening bloodstream infection) and meningitis (inflammation of the membranes surrounding the brain and spinal cord).

The St. Jude team found that pieces of cell wall from S. pneumoniae that escape from the bloodstream enter neurons (brain cells). In a previous report published in the July issue of Infection and Immunity, St. Jude researchers reported that in the mouse model, cell wall fragments damaged neurons in the part of the brain called the hippocampus. Tuomanen is senior author of both reports.

In the current study, the researchers showed how the cell wall fragments escape the bloodstream and enter cells. Specifically, they demonstrated that pieces of the bacterial cell wall bind to the vascular endothelium (inner surface of the blood vessel) by hooking onto a protein called platelet activating factor receptor (PAFr). Platelet activating factor (PAF) is an immune system signaling molecule that activates
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3

Related biology news :

1. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
2. Measuring hormone cuts antibiotic use in half in pneumonia patients
3. Bocavirus infection may be associated with pneumonia in Thailand, especially in children
4. UGA scientists unravel molecular inch-worm structure of walking-pneumonia bacterium
5. Lab-on-a-chip could speed up treatment of drug-resistant pneumonia
6. Bacteria from patients dental plaque causes ventilator-associated pneumonia
7. Anti-bacterial additive widespread in U.S. waterways
8. A bacterial genome reveals new targets to combat infectious disease
9. Scientists discover that host cell lipids facilitate bacterial movement
10. Family trees of ancient bacteria reveal evolutionary moves
11. Drug-resistant bacteria on poultry products differ by brand
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cell wall pneumonia bacteria can cause brain and heart damage

(Date:1/22/2015)...  Today, FreeWavz ( www.FreeWavz.com ), the developer of ... Fundable, https://www.fundable.com/freewavz . FreeWavz will be expanding ... meet customer demand. Logo - ... Invented by Dr. Eric ...
(Date:1/22/2015)... , Jan. 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... market, reports on the recent success of the Wocket™ smart wallet at ... Wocket smart wallet was named as one of the "11 Hot Products ... Best Products Launched At CES So Far" by Newseveryday.com and "The top ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 2
... Queen Mary, University of London have discovered how changes to ... a viral infection which is devastating frog populations across the ... being struck down by a foreign virus which is estimated ... UK each year. When it strikes garden ponds, the surrounding ...
... their belts: they start to digest their own proteins ... - takes place in special organelles called autophagosomes. It ... as a means of survival when times get tough, ... a kind of self-cleaning process. In mammalian cells, autophagosomes ...
... the logic of inheritance in his monastery garden with no ... House. So why couldn,t Darwin have done it too? A ... influences and research focus gave him a viewpoint that prevented ... even in his own work. Darwin,s commitment to ...
Cached Biology News:Frog's immune system is key in fight against killer virus 2Self-digestion as a means of survival 2Why didn't Darwin discover Mendel's laws? 2
(Date:1/22/2015)... 22, 2015 Controlled Substance Compliance Services ... helps companies check the legal requirements around using controlled ... China. , As their international operations expand and ... software solutions built as a result of the first ...
(Date:1/22/2015)... Jan. 22, 2015   Cypher Genomics, Inc., ... (NASDAQ: SQNM ), the leading molecular ... next generation noninvasive prenatal tests (NIPT). Through this ... called Mantis™, to advance analysis of clinically-relevant fetal ...
(Date:12/25/2014)... 25, 2014 The report “Service Quality ... Type & Provider Type - Global Advancements, Worldwide Forecasts ... an in-depth analysis and forecasting of revenues. , ... 221 pages and in-depth TOC on “Service Quality Management ...
(Date:12/24/2014)... BOTHELL, Wash. , Dec. 24, 2014   BioLife Solutions ... manufacturer and marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" or ... Annual Meeting of Stockholders on May 4, 2015 (the "Annual ...
Breaking Biology Technology:Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Inc.  (OTC Bulletin Board: MDXG ), an ... products and bioimplants processed from human amniotic membrane, announced ... 2010. Full Year 2010 ResultsIn 2010, ... the calendar year. Its prior fiscal year was from ...
... a global leader in scientific asset management, biomaterial storage, ... Piet Smet as Director of Business Development for its ... more than 20 years of experience in sales and ... new role, Smet will be responsible for leading the ...
... Mass. -- In recent years, many airplane manufacturers have ... consist of high-strength fibers, such as carbon or glass, ... are stronger and more lightweight than aluminum, but they ... their surfaces usually don,t reveal underlying problems. "With ...
Cached Biology Technology:MiMedx Group Announces 2010 Results 2MiMedx Group Announces 2010 Results 3MiMedx Group Announces 2010 Results 4MiMedx Group Announces 2010 Results 5MiMedx Group Announces 2010 Results 6MiMedx Group Announces 2010 Results 7BioStorage Technologies Appoints New Director of Business Development for European Operations 2MIT engineers devise new way to inspect materials used in airplanes 2