Navigation Links
Caterpillars tell us how bacteria cause disease

Caterpillars and other invertebrates are helping to provide a cheap, easy and safe way to identify the genes which help bacteria cause infections in humans. Researchers from the University of Bath have discovered a way to sort through large numbers of bacterial gene sequences by testing them in caterpillars to see how their immune systems respond. This new technique known as Rapid Virulence Annotation (RVA) allows them to pinpoint the genes which code for virulence.

With millions of species worldwide, insects provide a massive pool of hosts for bacterial diseases. The immune system of insects is very similar to the inborn immune system of mammals. By living first in insects some bacteria have evolved to survive immune system attack, so when they invade mammals they are equipped to deal with their immune system response and are able to spread rapidly. It is thought this is how bacteria, such as Yersinia pestis ?the cause of plague, could have evolved to wreak havoc in humans.

Dr Nick Waterfield, who is leading the study, explained: "Bacteria have been interacting with simple animals such as amoeba and insects for a staggering length of evolutionary time. It seems likely that most virulence genes around today probably first evolved to work against these hosts".

With funding from the Biotechnology and Biological Sciences Research Council's (BBSRC) Exploiting Genomics Initiative, Dr Waterfield and his team are using the similarities between insect immune systems and animal immune systems to their advantage by developing RVA - a new way to investigate the genetic basis of 'virulence' factors in insect pathogens. Instead of looking at the whole genome ?which codes for the entire bacteria, Dr Waterfield's team fragment the genome and insert different genes into a harmless laboratory bacterium which they then insert into caterpillars and other invertebrates to study their immune response.

"We are very excited by the opportunities that
'"/>

Source:Biotechnology and Biological Sciences Research Council


Page: 1 2 3

Related biology news :

1. Anti-bacterial additive widespread in U.S. waterways
2. A bacterial genome reveals new targets to combat infectious disease
3. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
4. Scientists discover that host cell lipids facilitate bacterial movement
5. Family trees of ancient bacteria reveal evolutionary moves
6. Drug-resistant bacteria on poultry products differ by brand
7. Programmable cells: Engineer turns bacteria into living computers
8. NASA links nanobacteria to kidney stones and other diseases
9. Substance protects resilient staph bacteria
10. Physiological effects of reduced gravity on bacteria
11. Anammox bacteria produce nitrogen gas in oceans snackbar
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Caterpillars tell how bacteria cause disease

(Date:4/23/2014)... Speed-reading is a technique used to read quickly. ... and skipping non-essential words and/ or sentences. Similarly ... pressure to quickly "read" genetic information. Genes that ... as the smaller the encoding message, the easier ... researchers from Instituto Gulbenkian de Cincia (IGC, Portugal) ...
(Date:4/22/2014)... researchers will lead a five-year, $3 million study to ... affecting the transport of dissolved organic matter (DOM) through ... alter the chemical composition and water quality of the ... the National Science Foundation,s MacroSystems Biology program, researchers will ... which begins in Canada and runs through five U.S. ...
(Date:4/22/2014)... PETA International Science Consortium Ltd.,s nanotechnology expert will present ... nanomaterial hazard assessment" at the 7th International Nanotoxicology ... Antalya, Turkey. , Dr. Monita Sharma will outline ... US National Academy of Sciences, " Toxicity Testing in ... which recommends use of non-animal methods involving human cells ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3
... study of how weight may affect school attendance, researchers ... found that overweight children are at greater risk of ... of more than a thousand 4th, 5th and 6th ... body mass index, or BMI, is as significant a ...
... Louis, Aug. 10, 2007 Heart disease hits people ... In those with diabetes, cardiovascular complications occur at an ... heart disease the major killer of diabetic people. But ... help answer that question, researchers at Washington University School ...
... - A new imaging technique developed at MIT has allowed ... cell, using a method similar to the X-ray CT scans ... described in a paper published in the Aug. 12 online ... most detailed images yet of what goes on inside a ...
Cached Biology News:Childhood obesity indicates greater risk of school absenteeism, Penn study reveals 2Abnormal fat metabolism underlies heart problems in diabetic patients 2Abnormal fat metabolism underlies heart problems in diabetic patients 3MIT creates 3-D images of living cell 2
(Date:1/14/2014)... Texas , Jan. 14, 2014 The ... and research medicinal plants and therapeutic derivatives thereof ... health professionals, and researchers about the challenges of ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation ... developing and commercializing innovative therapies addressing major unmet ... it received the Notice of Allowance from the ... unique self-delivering RNAi compounds (sd-rxRNA®), for the treatment ...
(Date:1/14/2014)... OTTAWA, Ontario , Jan. 14, 2014   Kinaxis ®, ... ( SCM ) and sales and operations planning ( S&OP ... the Biomanufacturing Summit , which will be held at ...  At the conference, join Kinaxis customer Elisabeth Kaszas , ...
Breaking Biology Technology:World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Leading Non-Fusion Spine Surgeon Supports Company,s Goals for Global ... ... Corporation, a spine care,services organization that partners with hospitals and ... has appointed Dr. Rudolf Bertagnoli, chairman and founder,of ProSpine (Bogen, ...
... Conduct Update Call on Tuesday, August 12, 2008, ... ENMD ), a clinical-stage pharmaceutical company developing,therapeutics ... today,reported financial results for the three and six-month ... ), The Company reported a net ...
... conserve cash while seeking financing/strategic ... ... Bulletin Board: ABOS) announced today that the Company is focusing its,day-to-day ... to preserve the Company,s remaining cash,resources, the Company,s employees were released ...
Cached Biology Technology:SpineMark Appoints Dr. Rudolf Bertagnoli Chairman of International Medical Advisory Board 2EntreMed Reports Second Quarter 2008 Financial Results 2EntreMed Reports Second Quarter 2008 Financial Results 3EntreMed Reports Second Quarter 2008 Financial Results 4EntreMed Reports Second Quarter 2008 Financial Results 5Arbios Announces It Has Suspended Operations 2Arbios Announces It Has Suspended Operations 3Arbios Announces It Has Suspended Operations 4Arbios Announces It Has Suspended Operations 5
... adapter allows the Thermo-Fast® ... AB-1000) PCR plates to ... ABI PRISM® 3700 capillary ... for information on the ...
Spectrolyse (pL) PAI kit is a two-stage indirect enzymatic assay for the quantitative determination of Plasminogen Activator Inhibitor (PAI-1) activity in plasma. Sample Type: plasma...
Rabbit anti-CRSP1 (TRAP220), Polyclonal Antibody, Unconjugated Applications: Immunohistochemistry - 1:100 - 1:500...
... White lyophilized solid. PROTECT FROM LIGHT. PACKAGED ... of γ-secretase. Equipotently inhibits the release of ... 2.6 μM) and Aβ x-42 (ED ... cells stably transfected with the Amyloid Precursor ...
Biology Products: