Navigation Links
Catching cancer's spread by watching hemoglobin

important for monitoring tumors, because the oxygenation state around cancerous tissue and the size and density of blood vessels around the tumor can provide a lot of information about the progression of a tumor and its response to anti-cancer drugs.

In the technique, two lasers at different wavelengths (colors) send ultra-short pulses (lasting only a femtosecond, or a quadrillionth of a second) on a blood vessel. The hemoglobin absorbs light from both of these lasers at the same time, in a process known as "two-photon absorption," and then gives off signals that can be detected to build up an image. One "pump" laser boosts (excites) hemoglobin molecules to a higher energy state. The other "probe" laser monitors the hemoglobin after the excitation. Sometimes the pump laser is off and there is no two-photon absorption. By subtracting the signal from the "off" state from the "on" state (when two-photon absorption occurs), the researchers remove unwanted scattered light from the data and can get high-quality signals from hemoglobin molecules.

To map out the hemoglobin distribution, the researchers scan laser beams across the sample, a process that then reveals the outlines and contours of blood vessels. By taking images at different depths and stacking these images layer by layer, the researchers can reconstruct 3-D images of blood vessels.

A major advantage of the technique is that it is "label-free," meaning it does not require the addition of fluorescing molecules but rather relies on the inherent light-absorbing properties of hemoglobin. While the technique has been demonstrated in vitro (by excising tissue samples and imaging the vessels on a glass dish), imaging in the living body is possible either for vessels up to a millimeter below the surface or through the use of minimally invasive probes, being developed in various labs, that can be inserted in the body.

Meeting Paper: CTuF1, "Two-Photon Absorption Imaging of H
'"/>

Source:Optical Society of America


Page: 1 2 3

Related biology news :

1. New understanding of cell movement may yield ways to brake cancers spread
2. Attacking cancers sweet tooth is effective strategy against tumors
3. Anti-bacterial additive widespread in U.S. waterways
4. HIV-1 spread through six transmission lines in the UK
5. Reservoirs may accelerate the spread of invasive aquatic species, researchers say
6. Undesirable expatriates: Preventing the spread of invasive animals
7. Nanobacteria in clouds could spread disease, scientists claim
8. Rabies spread speeds up
9. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
10. Industrial contaminants spread by seabirds in High Arctic, new Canadian study shows
11. Past droughts geographically widespread in the West, according to tree-ring data
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Catching cancer spread watching hemoglobin

(Date:12/5/2014)... Dec. 4, 2014 Increased emphasis on ... in new testing and inspection technologies. The convergence ... to a range of innovative test solutions. This ... Generation Y, which is generally more inclined towards ... product development strategies of test equipment vendors will ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin ... deployed, innovative test solutions for military, aerospace, and ... version of its successful TS-900 PXI semiconductor ... and features of high-end systems to customers at ... value compared to traditional ATE. ...
(Date:11/21/2014)... YORK , Nov. 19, 2014  Earlier this ... at New York College, and one of the most ... biosensor signals that are transmitted from Smartphones to third ... were Smartphones and has one of the earliest known ... discussing its usage in the military, child care, elder ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4
... a part of the National Institutes of Health ... million to fund three new Institutional Development Awards ... concentrating on one general area of research ... research infrastructure. The IDeA program is designed to ...
... altering the Earths chemistry. Many of societys most pressing ... from human activities that disrupt natural chemical cycles. Moving ... reversing actions that have such a huge impact on ... of the Institute of Ecosystem Studies, Dr. William H. ...
... -- Three researchers at the Albert Einstein College of ... Research Foundation (BCRF). Drs. Thomas Rohan, Susan Horwitz and ... its ongoing effort to support the advancement of breast ... is its mission, which is to achieve prevention and ...
Cached Biology News:NIH grants $33 M in institutional development awards to 3 states 2Biogeochemistry -- A window into the Earth's ecological health 2Einstein researchers receive grants totaling $700,000 for innovative breast cancer research 2
(Date:12/13/2014)... Taiwan (PRWEB) December 12, 2014 Trend ... indicators in overall global economic growth, Eugene Arthurs, CEO ... photonics , said in a featured talk at OPTIC ... December at the National Chung Hsing University in Taichung. ... being integrated into future energy supplies and soon to ...
(Date:12/13/2014)... New York, New York (PRWEB) December 13, 2014 ... expansion of its global network and Cold Chain capabilities, ... new Control Tower in Paris, France, to serve Life ... brand new facility equipped with a controlled-ambient warehouse, will ... in-transit storage for vaccines and investigational drugs, patient-clinical specimens, ...
(Date:12/13/2014)... ROCHESTER, N.Y. , Dec. 12, 2014 ... engaged in the discovery and development of ... neurodegenerative diseases, today announced publication of a ... microglia, and inhibits remyelination in neurodegenerative disease" ... journal Neurobiology of Disease*.  The publication highlights ...
(Date:12/12/2014)... Graphite Metallizing Corporation, the manufacturer of ... process equipment, has appointed Kirk Staller as Sales Engineering ... Staller holds a B.S. degree from Purdue University and ... place, much of it with a manufacturer of centrifugal ... office. , “We are pleased to have ...
Breaking Biology Technology:Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5Quick Opens Office in France to Serve Life Science Community In France and Neighboring French-Speaking Countries 2Vaccinex announces publication of preclinical studies with an anti-SEMA4D antibody in animal models of neuroinflammatory and demyelinating disease 2Kirk Staller Joins Graphite Metallizing Corporation 2
... , No more siRNA design and testing , ... 1 day , , ... , Simplify Your Gene , ... use of small interfering RNAs (siRNAs) to induce targeted gene , ...
... Ambion scientists have engineered a mutant form of ... full-length cDNA. This engineered reverse transcriptase, , <A ... href="http://www.ambion.com/catalog/CatNum.php?2048">ArrayScript , (patent pending), ... than wild type RTs, and rivals even the newest engineered RTs on , ...
... offers a complete Gene Expression Profiling Service* for Affymetrix , ... Service offering, , no project is too ... consultation with Ambion's team of experienced array and informatics ... long history of providing innovative, , high ...
Cached Biology Technology:Avoid siRNA Design Altogether! 2Avoid siRNA Design Altogether! 3ArrayScript RT: Maximize Yields of Full-length cDNA 2ArrayScript RT: Maximize Yields of Full-length cDNA 3Ambion Offers Gene Expression Profiling Service 2Ambion Offers Gene Expression Profiling Service 3
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
... number is a new ... easily match Cornings product ... availability yet, please order ... number (Z71,448-8) or contact ...
A convenience pack containing one each of the most popular sizes of Cat. No. 4980 flask. Designed for the low volume user, a case contains one each of five sizes: 50mL, 125mL, 250mL, 500mL, and 1L....
Biology Products: