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Carnegie Mellon scientists create PNA molecule with potential to build nanodevices

entirely different between humans and chimps, whose lineages diverged about 5 million years ago. The explanation for this difference is unknown, but the finding highlights the fact that significant changes in gene expression patterns, and thus changes in many effects of the aging process, can accumulate over relatively short stretches of evolutionary time.

These results raise a number of questions about age-related gene expression changes, including whether metabolically active non-brain tissues display similar patterns of changes, and whether the divergence between human and chimp patterns was the direct result of selection, or was an inevitable consequence of some other difference in brain evolution. The patterns seen in this study also provide a starting point for understanding the network of genetic changes in aging, and may even reveal targets for treatment of neurodegenerative diseases.


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