Navigation Links
Carnegie Mellon researchers discover new cell properties

Carnegie Mellon University researchers Kris Noel Dahl and Mohammad F. Islam have made a new breakthrough for children suffering from an extremely rare disease that accelerates the aging process by about seven times the normal rate.

Dahl, an assistant professor of chemical and biomedical engineering at Carnegie Mellon, said her work with researchers at the National Cancer Institute of the National Institutes of Health (NIH), the John Hopkins University School of Medicine and the University of Pennsylvania reveals that children suffering from Hutchinson-Gilford Progeria Syndrome (HGPS) have an excessively stiff shell of proteins.

The nucleus in all three trillion cells of the human body contains the DNA genome, which is wrapped with a stiff protein shell called the nuclear lamina. Children with HGPS have a mutation in one of the proteins of the lamina shell. For years, experts have thought this mutation made their nuclei much softer and more likely to be ruptured when cells were under stress.

But in a Proceedings of the National Academy of Sciences (PNAS) Journal article to be published this month, Dahl and her colleagues show that the lamina shell in HGPS patients is stiffer than normal. However, stiffer isn't necessarily better. The stiffer lamina did protect the HGPS nucleus from some forces, but under excessive force the HGPS lamina was more brittle and eventually fractured.

"The mutant HGPS lamina is like an egg shell that cracks when excessive pressure or force is exerted against it," Dahl said. "By contrast, normal lamina resembles the rubbery outer shell of a racquetball, which does not break under stress or force but can assume its original shape even after hard play."

The researchers also think that the stiffer lamina in HGPS patients may be unable to communicate the proper biological signals to the DNA inside the nucleus to help the cell grow, which contributes to the disease.

Islam, an assistant professor of chemical engineering and materials science and engineering, says that the increased stiffness of the lamina may be caused by mutant proteins self-organizing into ordered structures within the HGPS lamina.

"This could make the lamina stiffer and cause fractures in the nuclei," Islam said. The healthy lamina remains disordered and therefore less rigid.

"Once we understand what causes the lamina to stiffen, we can try to reverse or stop the problem," Dahl said. "We think this stiffening mechanism happens over time with increased protein concentration, so we need to determine the tipping point that causes real problems."

When people grow old, the walls of the cell nuclei exhibit similar problems to the HGPS nuclei, like losing their round shape and perkiness. "Our NIH collaborators have also found that the normal aged nuclei show the same structural changes as HGPS," Dahl said.


'"/>

Source:Carnegie Mellon University


Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
10. Carnegie Mellon scientists show brain uses optimal code for sound
11. DNA conclusive yet still controversial, Carnegie Mellon professor says
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... York , April 19, 2017 ... as its vendor landscape is marked by the presence ... market is however held by five major players - ... Together these companies accounted for nearly 61% of the ... the leading companies in the global military biometrics market ...
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... , ... September 20, 2017 , ... ... that it has appointed Vishwas Paralkar to the role of chief scientific officer. ... technology. He will report to Cybrexa’s president and CEO, Per Hellsund. , “I ...
(Date:9/20/2017)... Blue Bell, PA and College Station, TX (PRWEB) , ... ... ... IPS-Integrated Project Services, LLC (IPS), a leading global provider ... G-CON Manufacturing, Inc. the leading provider of prefabricated cleanrooms, today announced the ...
(Date:9/20/2017)... (PRWEB) , ... September 20, ... ... recently published findings of a study examining the effects of exoskeleton-assisted walking ... spinal cord injury (SCI). The article, "Neuromechanical adaptations during a robotic powered ...
(Date:9/20/2017)... ... September 20, 2017 , ... Foresight ... manufacturing and other transformative technologies, announced the winners for the 2017 Foresight Institute ... for Theory in nanotechnology/molecular manufacturing. , Established in 1993 and named in honor ...
Breaking Biology Technology: