Navigation Links
Carnegie Mellon researchers discover new cell properties

Carnegie Mellon University researchers Kris Noel Dahl and Mohammad F. Islam have made a new breakthrough for children suffering from an extremely rare disease that accelerates the aging process by about seven times the normal rate.

Dahl, an assistant professor of chemical and biomedical engineering at Carnegie Mellon, said her work with researchers at the National Cancer Institute of the National Institutes of Health (NIH), the John Hopkins University School of Medicine and the University of Pennsylvania reveals that children suffering from Hutchinson-Gilford Progeria Syndrome (HGPS) have an excessively stiff shell of proteins.

The nucleus in all three trillion cells of the human body contains the DNA genome, which is wrapped with a stiff protein shell called the nuclear lamina. Children with HGPS have a mutation in one of the proteins of the lamina shell. For years, experts have thought this mutation made their nuclei much softer and more likely to be ruptured when cells were under stress.

But in a Proceedings of the National Academy of Sciences (PNAS) Journal article to be published this month, Dahl and her colleagues show that the lamina shell in HGPS patients is stiffer than normal. However, stiffer isn't necessarily better. The stiffer lamina did protect the HGPS nucleus from some forces, but under excessive force the HGPS lamina was more brittle and eventually fractured.

"The mutant HGPS lamina is like an egg shell that cracks when excessive pressure or force is exerted against it," Dahl said. "By contrast, normal lamina resembles the rubbery outer shell of a racquetball, which does not break under stress or force but can assume its original shape even after hard play."

The researchers also think that the stiffer lamina in HGPS patients may be unable to communicate the proper biological signals to the DNA inside the nucleus to help the cell grow, which contributes to the disease.

Islam, an assistant professor of
'"/>

Source:Carnegie Mellon University


Page: 1 2

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
10. Carnegie Mellon scientists show brain uses optimal code for sound
11. DNA conclusive yet still controversial, Carnegie Mellon professor says
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Carnegie Mellon researchers discover new cell properties

(Date:7/30/2014)... Wallerian degeneration is a subject of major interest ... differentially regulated during the distinct stages of Wallerian ... differentiation and dedifferentiation. Although gene expression responses in ... peripheral nerve injury are known, differences in gene ... unclear. Dr. Dengbing Yao and co-workers from Nantong ...
(Date:7/30/2014)... the roughly 3,000 pieces is still in its infant ... will be of major significance. "Amazingly often, we are ... Fushun amber that we found in Baltic amber," explained ... Baltic amber comes from the Baltic Sea region, which ... finds are, e.g., the coastal regions of Mecklenburg, Poland ...
(Date:7/29/2014)... of Bristol,s Nutrition and Behaviour Unit (NBU) has looked ... planning meals. , The research, to be presented at ... (SSIB 2014) in Seattle, USA this week [29 July ... team was led by Professor Jeff Brunstrom, and is ... part of a Biotechnology and Biological Sciences Research Council ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... continues to reduce its carbon footprint through enhanced sustainability ... efforts have been crucial to the university,s recent recognition ... Colleges." UH has been recognized as a green university ... "UH is thrilled to be recognized again by The ...
... Botanic Gardens, Kew (RBG Kew), the Royal Botanic Garden ... the Missouri Botanical Garden (MBG), have announced plans to ... the world,s plantsto be made available by the year ... information on up to 400,000 plant species worldwide. It ...
... they were the ultimate survivors. They successfully negotiated three ... end of the Cretaceous along with the dinosaurs: Ammonoids, ... cephalopods believed to be related to today,s squid and ... the course of evolution. However, what was once a ...
Cached Biology News:UH makes Princeton Review's Green List 3 years in a row 2Botanical institutions announce plans to create first online World Flora 2Botanical institutions announce plans to create first online World Flora 3First fruitful, then futile: Ammonites or the boon and bane of many offspring 2
(Date:7/30/2014)... (PRWEB) July 30, 2014 Adding to ... weighing boat special – Buy 2 of ... This promotion will benefit lab technicians looking for durable ... boats are ideal for multiple applications including weighing liquids, ... variety of choices including diamond-shaped, hexagonal, square, aluminum weighing, ...
(Date:7/29/2014)... SoundConnect , an award ... proud to announce the strategic additions of implementation, ... Boston, Charleston and Atlanta offices. SoundConnect’s organizational ... for hosted solutions, collaboration and mobility that improve ... , SoundConnect was founded in 2004, with the ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The advanced ... the brain that are driving a revolution in the ... new peer-reviewed journal published by SPIE, the international ... issue coincides with the launch of the BRAIN Initiative ... articles that lay out a vision for and provide ...
(Date:7/29/2014)... particle be separated from its properties? On July 29, ... results of the first Cheshire Cat experiment, separating a ... in Orange, CA, and Vienna University of Technology. , ... grin," thought Alice in Wonderland, "but a grin without ... saw in my life!" Alice,s surprise stems from her ...
Breaking Biology Technology:Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2SoundConnect Organization and Culture is Evolving 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 2SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 3SPIE Launches 'Neurophotonics' Journal with Special Section on BRAIN Initiative 4The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4
... Formulation and CHO cGMP Media Library for Cell Culture ... a business segment within SAFC(R), a member of the ... that it has expanded its portfolio of products and ... line applications with the introduction of EX-CELL(TM) CD ...
... 8 Advanced Life Sciences Holdings, Inc. (Nasdaq: ... novel once-a-day antibiotic, to treat respiratory tract infections and ... filed a shelf registration statement on Form S-3 with ... and when the shelf registration statement is declared effective ...
... guide designed to help consulting engineers and ... environmentsBUFFALO GROVE, Ill., April 8 Siemens ... Life Science Solutions Design Guide written expressly ... are looking to design and specify effective ...
Cached Biology Technology:SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 2SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 3SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 4Advanced Life Sciences Announces Filing of Shelf Registration Statement 2Advanced Life Sciences Announces Filing of Shelf Registration Statement 3Siemens Offers Life Science Solutions Design Guide for Consulting Engineers 2
Mouse monoclonal antibody raised against a full length recombinant GPT. NCBI Entrez Gene ID = GPT...
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... Each kit contains sufficient materials for 1,464 array sample ... Membrane: 4 each , Blocker BSA in PBS (10X): ... BupH Phosphate Buffered Saline: 8 packs , 10% Tween-20: ... Luminol Enhancer: 2 x 25 ml , SuperSignal West ...
... 100-120 V, is used for biolistic particle ... device employs an adjustable helium pulse to ... microcarriers from the inner wall of a ... This system has a 2 square-centimeter target ...
Biology Products: