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Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

new, real-time tracking method is very good at pinpointing exactly when and where rejection is taking place.

The researchers used a heterotropic heart model to study organ rejection. In this model, a rat receives a second functional heart, which is grafted into its abdomen. The rat's native heart functions normally. In this way, the researchers can study how a transplanted heart changes through sequential stages of rejection while the rat stays healthy. This aspect of the research was conducted primarily by Qing Ye, a research biologist at the Pittsburgh NMR Center for Biomedical Research.

Ho's team at the Pittsburgh NMR Center for Biomedical Research is now pursuing research using larger animal models. They are collaborating with researchers at the University of Pittsburgh School of Medicine, including Dr. David Cooper, professor of surgery in the Thomas E. Starzl Transplantation Institute; Dr. Jeffrey Teuteberg, assistant professor of medicine at the Cardiovascular Institute, Heart Failure/Transplantation; and Dr. Fernando Boada, associate professor in the Department of Radiology.


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Source:Carnegie Mellon University


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