Navigation Links
Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

for a few years to monitor and treat any rejection. Biopsies also are problematic, according to Ho, because they do not look at the whole organ. By only sampling several small areas, a biopsy may miss the area of the transplanted organ where immune cells are gathering -- one of the first signs of rejection.

Ho's novel approach investigates transplant rejection non-invasively by observing macrophage accumulation in heart tissues using MRI.

"We were able to use MRI to visualize individual macrophages. By tracking individual cells, we also were able to observe, for the first time, that rejection progresses from the outside of the heart to the inside," said Ho. "Up to now, this phenomenon hasn't been observed in pre-clinical or clinical research because biopsy samples are very limited in location and size."

The reported findings also have broader implications for biology and medicine, according to Ho.

"We now have the ability to visualize non-invasively and with sensitivity individual cells and their movement to targeted sites. Our new approach offers almost unlimited potential for monitoring cell therapies, such as those using stem cells, and for tracking cellular and developmental processes," Ho said.

For the research reported in PNAS, Yijen Wu, research biologist at the Pittsburgh NMR Center for Biomedical Research, tagged macrophages with nanometer (USPIO)- or micrometer (MPIO)-sized paramagnetic iron oxide particles, which are very sensitive to the magnetic fields used during MRI. Wu injected the MPIO or USPIO particles into rats that had received heart transplants three days earlier. Macrophages, which typically ingest foreign materials inside the body (bacteria, for example), incorporated the particles. Using MRI, the researchers then track tagged macrophages that infiltrate transplanted hearts. The locations of the tagged macrophages are highly defined and appear circular in shape, said Wu. This finding indicates that the
'"/>

Source:Carnegie Mellon University


Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
9. Carnegie Mellon scientists show brain uses optimal code for sound
10. DNA conclusive yet still controversial, Carnegie Mellon professor says
11. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds
Post Your Comments:
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, ... licensed its PerformTek biometric technology to industry leaders such ... highly accurate, clinically validated, biometric wearable products. These products ... 6-9 in Las Vegas . ... technology is accurate, flexible and robust – with the ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ... 2015-2019"  report to their offering. ... advances in technology. With continuous advances in technology, ... the latest standard that meets the needs and ...
(Date:12/10/2014)... You,ve been here before: you desperately need to ... password, site key or the answer to your secret question. ... Today, Hoyos Labs , a digital ... finally put an end to the frustration that comes with ... 1U leverages a user,s smartphone to acquire his or her ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... marine invertebrates worms, sponges, jellyfish - have the ... than two cells: a photoreceptor cell and a pigment ... suggested by Charles Darwin as the first eyes to ... allow the animal to sense the direction of light. ...
... Chemical Society (ACS) News Service Weekly PressPac with news from ... .,Please credit the individual journal or the American Chemical Society ... FOR IMMEDIATE RELEASE EXCEPT ARTICLE #5, which is embargoed for ... ARTICLE #1 FOR IMMEDIATE RELEASE Microcapsules act as ...
... a few extra treats this holiday season? Soon, your ... your exercise routine and keep the pounds off over ... to keep track. Researchers at the University of ... applications, dubbed UbiFit and UbiGreen, to automatically track workouts ...
Cached Biology News:Uncovering secrets of life in the ocean 2American Chemical Society's Weekly PressPac -- Nov. 19, 2008 2American Chemical Society's Weekly PressPac -- Nov. 19, 2008 3American Chemical Society's Weekly PressPac -- Nov. 19, 2008 4American Chemical Society's Weekly PressPac -- Nov. 19, 2008 5American Chemical Society's Weekly PressPac -- Nov. 19, 2008 6American Chemical Society's Weekly PressPac -- Nov. 19, 2008 7American Chemical Society's Weekly PressPac -- Nov. 19, 2008 8Track your fitness, environmental impact with new cell phone applications 2Track your fitness, environmental impact with new cell phone applications 3
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... State University have developed a cheap and easy ... density. The researchers hope the findings will foster ... using nanowires, from nanoelectronics to nanosensors, especially on ... "Alignment is a critical first step for ...
... CAMBRIDGE, Mass., Feb. 28, 2011 Idenix Pharmaceuticals, Inc. ... in the discovery and development of drugs for the ... results for the fourth quarter and year ended December ... cash equivalents totaled $46.1 million. ...
... Feb. 28, 2011 Verenium Corporation (Nasdaq: ... specialty enzymes, today announced that Terminal 6, a major ... begun use of Verenium,s Purifine enzymatic degumming process at ... enzymatic degumming is a novel process that significantly increases ...
Cached Biology Technology:Stretched rubber offers simpler method for assembling nanowires 2Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 2Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 3Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 4Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 5Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 6Idenix Pharmaceuticals Reports Fourth Quarter and Year End 2010 Financial Results 7World's Largest Soybean Processing Industrial Complex Converts Half of Capacity to Usage of Verenium's Purifine® PLC Enzymatic Degumming Process Engineered and Installed by Alfa Laval 2World's Largest Soybean Processing Industrial Complex Converts Half of Capacity to Usage of Verenium's Purifine® PLC Enzymatic Degumming Process Engineered and Installed by Alfa Laval 3World's Largest Soybean Processing Industrial Complex Converts Half of Capacity to Usage of Verenium's Purifine® PLC Enzymatic Degumming Process Engineered and Installed by Alfa Laval 4
Human ROR1 Affinity Purified Polyclonal Ab...
Ultra-sensitive, non-radioactive measurement of COX-I and COX-II activity...
Phospho-p70 S6 Kinase (T229) Affinity Purified PAb...
Recombinant Ovine (Sheep) Growth Hormone, Ultra Pure...
Biology Products: