Navigation Links
Carnegie Mellon University research reveals how cells process large genes

ons for predicting what constitutes a gene and for studying gene expression, mutation and evolution, according to Lopez.

For example, recursive splicing must now be taken into account when evaluating mutations that disrupt gene expression and produce a dysfunctional or non-functional protein.

"Current data indicate that at least 15 percent of disease-causing mutations occur at standard signals where intron removal takes place through direct splicing. Mutations at recursive splice sites may cause additional diseases, but until now we haven't looked for them."

Knowledge of recursive splicing also will help investigators predict structures of genes that span large intervals of DNA, Lopez said.

Recursive splicing relies on the unusual activity of a ratchetting point, a pattern of chemical groups (nucleotides) previously discovered within the genome by Lopez. One end of a ratchetting point contains a sequence of nucleotides similar to the signal normally found at the beginning of an intron. This signal is juxtaposed with another sequence like that normally found at the end of an intron. Such a unique pairing allows a ratchetting point to function sequentially as an acceptor for splicing to an upstream exon and then as a donor for splicing to the next downstream ratchetting point or exon. As the process goes from ratchetting point to ratchetting point, small signature loops of RNA called lariats are released from the intron. Repeated over and over, recursive splicing eventually binds, or ligates, two distant exons.

Lopez's team developed molecular tools to analyze the lariats released from any intron during splicing in vivo. In his analyses, he found that the production of recursive lariats greatly exceeded that of direct lariats, indicating that recursive splicing is the predominant processing pathway for long introns. Lopez combined these experimental data with computational and phylogenetic analyses of several fruitfly and oth
'"/>

Source:Carnegie Mellon University


Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
5. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
6. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
7. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
8. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
9. Carnegie Mellon scientists show brain uses optimal code for sound
10. DNA conclusive yet still controversial, Carnegie Mellon professor says
11. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds
Post Your Comments:
(Date:7/31/2014)... the photovoltaic effect in 1839, humankind has sought to ... its own purposes. In a new research report published ... FASEB Journal , scientists may have uncovered a ... focusing on a naturally occurring combination of lipids that ... over time and across speciessuggests that this specific natural ...
(Date:7/31/2014)... In the same week that the U.S. surgeon ... skin cancer, researchers at Montana State University published a ... genetic code in every cell responds when exposed ... understanding of DNA damage by the UV rays found ... aging and some degenerative eye diseases. , "Our ...
(Date:7/31/2014)... Professor of Clinical Surgery at LSU Health Sciences Center ... team of plastic and reconstructive surgeons who report a ... select patients for a specific surgical migraine treatment technique. ... surgery to decompress the nerves that trigger migraines experienced ... The study, which confirms the benefit of surgical treatment ...
Breaking Biology News(10 mins):Scientists shine bright new light on how living things capture energy from the sun 2New paper describes how DNA avoids damage from UV light 2New paper describes how DNA avoids damage from UV light 3Surgeons report significant migraine relief from cosmetic eyelid surgery technique 2
... Diego have identified more than 70 genes that play a ... a valuable set of genetic leads for use in developing ... of nerve damage such as stroke. In the September ... detail their discoveries after an exhaustive two-year investigation of 654 ...
... A team of neuroscientists at Cold Spring Harbor Laboratory ... system for locating and tracking a vital class of brain ... living animals. The cells in question are ... (gamma aminobutyric acid). GABA neurons function to inhibit or ...
... mussels, squids as different as they may look, ... to the phylum Mollusca , also called molluscs. ... and Professor Ken Halanych, USA, with the participation of ... research into the relationships among different molluscs as part ...
Cached Biology News:UC San Diego biologists discover genes that repair nerves after injury 2UC San Diego biologists discover genes that repair nerves after injury 3Team creates genetic 'GPS' system to comprehensively locate and track inhibitory nerve cells 2Team creates genetic 'GPS' system to comprehensively locate and track inhibitory nerve cells 3Team creates genetic 'GPS' system to comprehensively locate and track inhibitory nerve cells 4Research into molluscan phylogeny reveals deep animal relationship of snails and mussels 2Research into molluscan phylogeny reveals deep animal relationship of snails and mussels 3
(Date:7/31/2014)... 31, 2014 Senomyx , Inc. ... using proprietary taste science technologies to discover, develop, ... beverage, and ingredient supply industries, today reported financial ... ended the second quarter with $33.6 million in ... "During the past quarter Senomyx achieved another important ...
(Date:7/31/2014)... 2014 Rancho BioSciences , the ... Omicsoft’s Array Suite with tranSMART . Scientists ... to send data in tranSMART to Array Suite for ... of tranSMART including the new 1.2 release. Array ... storage for the analysis of high dimensional quantification data, ...
(Date:7/31/2014)... 31, 2014   BioLife Solutions , Inc. (NASDAQ: ... marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues, today ... results will be released on Thursday, August 7, 2014, ... and live webcast at 4:30 p.m. ET that afternoon. ...
(Date:7/31/2014)... 31, 2014 Sales Horizons, a leader ... online sales training course – Mastering the Complex ... performance. , Drawn from proven sales training programs used ... the Complex Sale online sales training course is available ... has face-to-face contact with customers, like technical support, engineers, ...
Breaking Biology Technology:SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 2SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 3SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 4SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 5SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 6SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 7SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 8SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 9SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 10SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 11SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 12SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 13SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 14SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 15SENOMYX ANNOUNCES CORPORATE UPDATE AND SECOND QUARTER 2014 FINANCIAL RESULTS 16Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 2Rancho BioSciences, in Partnership with Omicsoft, have Integrated Array Suite with tranSMART 3BioLife Solutions to Report Financial Results for Second Quarter 2014 and Provide Business Update on August 7, 2014 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 2Sales Horizons Offers Mastering the Complex Sale - a Comprehensive, Online Sales Skills Training Course 3
... , Up to 50X ... Removes trace quantities of , ... RNase-free and recombinant in , ... lower in RNase activity than bovine pancreas , ...
... , ... fastest, easiest, and most consistent method for PAGE purification of ... , which was designed for the visualization of small nucleic ... for the purification of RNA , and DNA. ...
... ActivePro In Vitro Translation Kit , ... activity than those from other E. , coli lysate systems ... of prokaryotic and eukaryotic proteins , Fast translation and high protein ... , You really can have it all with the the , ...
Cached Biology Technology:TURBO DNase: Hyperactive, Salt Tolerant DNase 2TURBO DNase: Hyperactive, Salt Tolerant DNase 3TURBO DNase: Hyperactive, Salt Tolerant DNase 4TURBO DNase: Hyperactive, Salt Tolerant DNase 5Ultra-Fast Purification of Small Nucleic Acids 2Ultra-Fast Purification of Small Nucleic Acids 3Ultra-Fast Purification of Small Nucleic Acids 4Ultra-Fast Purification of Small Nucleic Acids 5Translate High Yields of Active Protein 2Translate High Yields of Active Protein 3
Candida (IgA) -Ab EIA Sample Size: 5 l...
... of optimized cell lines in combination ... the nucleofection parameters. Nucleofector Kits are ... Nucleofector Device., Different cell lines can ... corresponding efficiencies and viabilities are given ...
...
Request Info...
Biology Products: