Navigation Links
Carnegie Mellon University research reveals how cells process large genes

Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a functional protein or, worse, produce an abnormal protein that interferes with normal cell behavior. But just how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years.

Now, investigators at Carnegie Mellon University have discovered that a novel mechanism, called recursive splicing, removes long introns by steadily paring them down in a predictable fashion and joining the remaining exons. The findings are published this summer in Genetics. This process, which the investigators discovered in the fruit fly Drosophila, has been conserved over tens of millions of years of insect evolution and also appears likely to occur in humans, according to the investigators.

"While some scientists have suspected that large introns might not be removed in one piece through direct splicing, no one had identified how this could happen. Now we have identified a way," said Antonio-Javier Lopez, professor of biological sciences at Carnegie Mellon. Ultimately, recursive splicing could be responsible for thwarting molecular mishaps in the expression of large human genes associated with diseases like muscular dystrophy, cystic fibrosis and cancer.

"We found that many large introns are removed by multiple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now."

These previously undetected events could have profound implicati
'"/>

Source:Carnegie Mellon University


Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
5. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
6. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
7. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
8. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
9. Carnegie Mellon scientists show brain uses optimal code for sound
10. DNA conclusive yet still controversial, Carnegie Mellon professor says
11. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds
Post Your Comments:
(Date:8/27/2014)... West Orange, NJ. August 27, 2014. Using functional ... shown differential brain activation patterns between people with ... the first MS study in which brain activation ... cognitive task. The article, "Neuroimaging and cognition using ... was published online on June 11 by ...
(Date:8/27/2014)... have identified a gene that could help scientists engineer ... in the cell membrane of plants that senses changes ... machinery accordingly. , "It,s similar to a thermostat," ... Duke. , The findings, which appear Aug. 28 ... easier to feed the world,s growing population in the ...
(Date:8/27/2014)... of the HIV drug maraviroc, a new study from ... the drug was licensed in 2007, included mostly European-Americans, ... removing maraviroc from the body. The current study shows ... including nearly half of African-Americans end up with ... lack the protein even when given the same dose. ...
Breaking Biology News(10 mins):Kessler Foundation researchers publish first study of brain activation in MS using fNIRS 2Water 'thermostat' could help engineer drought-resistant crops 2Dosage of HIV drug may be ineffective for half of African-Americans 2
... one scratchy tune learned in its youth, which it ... occasionally, the finch might improvise, experimenting with a slower, ... studying the finch now say the improvisation arises from ... section of the forebrain that seems to generate the ...
... in St. Louis have discovered an entirely new cellular ... plant flowering and DNA methylation, a key chemical process ... by Craig Pikaard, Ph, D., Washington University professor of ... kind of RNA polymerase found only in plants and ...
... (CLL) is an incurable disease in which cells in the ... become abnormal and malignant (leukemic). The progression of the disease ... regarding the rate of production of CLL cells, and the ... believed that CLL was a static disease of long-lived lymphocytes ...
Cached Biology News:Bird Brains Show How Trial and Error May Contribute to Learning 2Bird Brains Show How Trial and Error May Contribute to Learning 3New RNA polymerase discovered in plants 2New RNA polymerase discovered in plants 3The very unexpected life and death of a leukemic cell 2
(Date:8/27/2014)... LONDON , Aug. 27, 2014 ... The Graphene Opportunity - A Rational ... Is Graphene The New Nanotech? A similar ... predictions of applications ranging from microelectronics to water ... today announced the availability of the Graphene Opportunity ...
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... the "Global Enzyme for Pulp & Paper Industry ... The Global Enzyme for Pulp & Paper Industry ... the current state of the global enzyme for pulp ... basic overview of the industry including definitions, classifications, applications ...
(Date:8/27/2014)...  ARCH Venture Partners, one of the largest ... of seed and early-stage advanced technology companies, today ... more than $400 million in subscriptions. ARCH Venture ... by more than $150 million. "The ... potential of our approach to finding and funding ...
(Date:8/27/2014)... Beach County, Florida (PRWEB) August 27, 2014 ... Company Inc. (SCI) is announcing the creation of ... priority is to take the SCI’s philosophy of ... the company’s research and development actions are based ... , This new Scientific Advisory Board provides a ...
Breaking Biology Technology:The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Global Enzyme for Pulp & Paper Industry Report 2014 2Latest ARCH Venture Partners Fund Closes Above $400 Million 2Latest ARCH Venture Partners Fund Closes Above $400 Million 3New Sancilio & Company, Inc. Scientific Board 2New Sancilio & Company, Inc. Scientific Board 3
... 14 Transgenomic, Inc. (the,"Company") (OTC Bulletin Board: TBIO) ... 2007. The Company,s financial results are,presented in the tables ... reported a net profit of $0.2 million or $0.00 ... to a net loss of $0.4 million or,$0.01 per ...
... Board of Directors,meeting held today, the Directors declared ... dividend is payable on September 14, 2007 to,shareholders ... Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and ... and kits,are used in scientific and genomic research, ...
... Quarter Last Year, - 17 Percent Quarter-to-Quarter Revenue Gain Evidences Start of Turnaround ... for Core Business ... - DelSite Signs Additional Agreements, IRVING, Texas, Aug. 14 Carrington,Laboratories, ... $5.6 million, compared to $6.5 million in the year ago,period. The revenue in the ...
Cached Biology Technology:Transgenomic, Inc. Reports Second Quarter 2007 Results 2Transgenomic, Inc. Reports Second Quarter 2007 Results 3Transgenomic, Inc. Reports Second Quarter 2007 Results 4Transgenomic, Inc. Reports Second Quarter 2007 Results 5Transgenomic, Inc. Reports Second Quarter 2007 Results 6Transgenomic, Inc. Reports Second Quarter 2007 Results 7Transgenomic, Inc. Reports Second Quarter 2007 Results 8Carrington Reports Second Quarter 2007 Results 2Carrington Reports Second Quarter 2007 Results 3Carrington Reports Second Quarter 2007 Results 4Carrington Reports Second Quarter 2007 Results 5Carrington Reports Second Quarter 2007 Results 6Carrington Reports Second Quarter 2007 Results 7
...
cysteine and glycine-rich protein 2,...
... Antitumour agent and DNA-topoisomersae II inhibitor (IC50 = ... C 29 H 32 O 13 ... Store at: RT ... Solubility: Soluble to 100 ...
HSPBP1 Antibody...
Biology Products: