Navigation Links
Carnegie Mellon University research reveals how cells process large genes

Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a functional protein or, worse, produce an abnormal protein that interferes with normal cell behavior. But just how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years.

Now, investigators at Carnegie Mellon University have discovered that a novel mechanism, called recursive splicing, removes long introns by steadily paring them down in a predictable fashion and joining the remaining exons. The findings are published this summer in Genetics. This process, which the investigators discovered in the fruit fly Drosophila, has been conserved over tens of millions of years of insect evolution and also appears likely to occur in humans, according to the investigators.

"While some scientists have suspected that large introns might not be removed in one piece through direct splicing, no one had identified how this could happen. Now we have identified a way," said Antonio-Javier Lopez, professor of biological sciences at Carnegie Mellon. Ultimately, recursive splicing could be responsible for thwarting molecular mishaps in the expression of large human genes associated with diseases like muscular dystrophy, cystic fibrosis and cancer.

"We found that many large introns are removed by multiple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work also indicates that most recursive splicing events leave no clues in the final mRNA. This is why they have not been detected before now."

These previously undetected events could have profound implicati
'"/>

Source:Carnegie Mellon University


Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
5. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
6. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
7. Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
8. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
9. Carnegie Mellon scientists show brain uses optimal code for sound
10. DNA conclusive yet still controversial, Carnegie Mellon professor says
11. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds
Post Your Comments:
(Date:12/5/2014)... 2014  Tute Genomics, a leader in cloud-based solutions ... A1 funding led by UK-based Eurovestech. Peak Ventures and ... investment round. "We are at a pivotal ... sequencing and seeks new approaches for the diagnosis, treatment ... MD MBA, and CEO of Tute Genomics. "One of ...
(Date:12/3/2014)... , Dec. 2, 2014 As part ... readers, Inception Technologies is pleased to announce the release ... for customers to collect the workforce data that they ... that have been left by existing readers. Many such ... interface, connectivity and modern technology. Older models force users ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4
... a climate as prone to extremes as Canada,s, buildings ... innovative solutions are being explored through the NSERC Smart ... initiative headquartered at Concordia, which has just received $1 ... "Through the ecoENERGY Innovation Initiative, our Government ...
... MNMay 2, 2013UnitedHealth Group and the Minneapolis Heart Institute ... of New Ulm, Minn., recently announced two grants from ... will fund weight management and nutrition initiatives for Hearts ... a research and demonstration project with a goal of ...
... to announce the launch of Environmental Science & ... accelerate the pace of research across the environmental field ... leading publishing outlet to highlight urgent critical findings in ... release its first issue January 2014 and open for ...
Cached Biology News:$1 million for smart energy solutions 2UnitedHealth Group grants more than $1 million for the heart of New Ulm project 2New ACS journal Environmental Science and Technology Letters to rapidly publish urgent research 2New ACS journal Environmental Science and Technology Letters to rapidly publish urgent research 3
(Date:12/24/2014)... (PRWEB) December 23, 2014 Nashville Fertility ... was elected treasurer for the American Society for Reproductive ... knowledge and research in reproductive medicine. In his ... seat on the executive board and will have a ... Dr. Hill has actively supported ASRM since 1984 when ...
(Date:12/24/2014)... 23, 2014 PharmaBoardroom,s new ... today and available for free download , digs deep ... and growth in the sector today. One area ... has been in developing a homegrown pharmaceutical manufacturing base, even ... still remains some way off. A cursory comparison with neighboring ...
(Date:12/22/2014)... , Dec. 22, 2014   Synthetic ... developer of pathogen-specific therapies for serious infections ... the microbiome, today announced positive topline safety ... clinical trial of SYN-004, the Company,s investigational ... Clostridium difficile (C. difficile) infection, ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 ... peer-reviewed publication of original research, reviews and editorials ... and clinical practice, today published a provocative article ... the development, progression and potential treatment of prostate ... endocrinology research and proposes the possibility that there ...
Breaking Biology Technology:Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 2Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 3Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 4Synthetic Biologics Announces Positive Topline Results from Phase 1a Trial of SYN-004 for the Prevention of C. difficile Infection 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4
... /PRNewswire-iReach/ -- Advanced Technological Education Television (ATETV), an award-winning ... Science Foundation , returns with 40 new videos just in ... a free Web video series featuring up to the minute ... employment opportunities. The series debuted in 2009 and has been ...
... CLEVELAND, Sept. 1, 2011 enLiven yogurt ( www.enlivenyogurt.com ), ... exclusively in Walmart, is helping parents and  kids eat healthier ... Giveaway" in September. By simply liking enLiven on Facebook or ... win a $100 Walmart grocery gift card each Wednesday in ...
... 2011 The medical imaging company SyntheticMR ... an order for their magnetic resonance imaging software from ... will be used in clinical practice to monitor the ... software, SyMRI Diagnostics, includes tools to automatically estimate a ...
Cached Biology Technology:New Videos Spotlight Science/Technology Careers and Educational Path To Secure Jobs in Them 2enLiven Yogurt Sponsors "Back to School Grocery Giveaway" to Keep Parents and Kids Eating Healthy Foods this Fall 2Swedish University Hospital Improves Monitoring of Treatment Efficacy in Multiple Sclerosis With Synthetic MRI Innovation 2Swedish University Hospital Improves Monitoring of Treatment Efficacy in Multiple Sclerosis With Synthetic MRI Innovation 3
Anti-Wnt-2 Polyclonal Antibody Description: 100 g purified goat polyclonal antibody. Reacts with human/mouse/rat. Tested in Western blot/IP/IHC. Research Focus: signal transduction Storage...
...
Mynox is intended for research use only. Mynox is used for the elimination of Mycoplasma and Acholeplasma in cell and virus cultures, and other biologicals....
... can be used to label ... covalently bound acridinium NHS ester ... presence of hydrogen peroxide. Acridinium ... used as a detection method ...
Biology Products: