es taking place during an experiment -- adding a chemical or changing the temperature, for instance. This aspect of the method provides scientists with the specificity they need to weed out such introduced gene activation from fundamental gene activation pathways that form the hallmark of processes like cancer or immunity. To prove the effectiveness of this new method, Bar-Joseph studied the human cell division cycle. Considered one of the most important biological systems, the cell cycle plays a major role in cancer. Using their new method, Bar-Joseph and his colleagues identified many new human genes that were not previously found to be participants in this system.
"This new set of gene discoveries opens the way to new and more accurate models of the cell cycle system, which in turn can lead to new targets for cancer drugs," said Bar-Joseph.
The new method also overcomes synchronization loss, a vexing problem for scientists who study hundreds or thousands of cells over time, according to Bar-Joseph. Large groups of living cells that start out together at the same biological point in time eventually become asynchronized in their activities, he noted.
"You can compare a group of cells starting out in an experiment like a group of marathoners at the starting line. Over time, some marathoners will be far ahead on the track, while others will fall back." After the race begins, finding one marathoner among the thousands is difficult. Similarly, with asynchronous cells, trying to sort out a single cell response is virtually impossible. But Bar-Joseph has incorporated mathematical tools in his method that can detect genes affected by such asynchrony in a population of cells.
Source:Carnegie Mellon University
Page: 1 2 3 Related biology news :1
. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals2
. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert3
. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University4
. Carnegie Mellon University research reveals how cells process large genes5
. Carnegie Mellon cyLab researchers work to develop new red tide monitoring6
. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace7
. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices8
. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level9
. Carnegie Mellon scientists show brain uses optimal code for sound10
. DNA conclusive yet still controversial, Carnegie Mellon professor says11
. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds