Navigation Links
Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool

ul, they present a sampling problem," Bar-Joseph said. "DNA microarrays only take static snapshots of gene activity over time. In between these snapshots, genes could be activated and we just don't see them turning on. Our protocol will offer greater overall sensitivity in detecting the expression of any gene, even if a gene turns on when no microarray sampling takes place."

Bar-Joseph's procedure is based on a "check-sum" protocol initially developed to ensure that email messages sent via the Internet don't become garbled in transmission. In the standard Internet check-sum protocol, bits of information that begin as one value (0 or 1) may inadvertently flip to the opposite value as they move from one computer to the next in the form of an email. This data loss, ascribed to noise in the communication channel, is checked by counting the number of 1's in the message. If this number is odd, then the last bit is set to 1; otherwise it is set to 0. By comparing the number of 1's on the sending end with the value of the last bit on the receiving end, the recipient's computer can determine whether the message was accurately received. If not, the recipient's computer asks the sender's computer to forward the message again.

Bar-Joseph's method carries out a similar analysis of the microarray snapshots by "checking" the sum of a set of DNA microarray data points over time (a time series experiment) against the "summary" of the temporal response. If the two sets of results are equal, then what is captured by the DNA microarray time series is real. If the time series results produce a lower value than the microarray summary, the protocol indicates that the researchers have missed a gene's activation somewhere in their time series.

Just as important, according to Bar-Joseph, is whether a DNA microarray summary value exceeds its time sequence value. If that's the case, then researchers have likely identified gene activity that should be attributed to chang
'"/>

Source:Carnegie Mellon University


Page: 1 2 3

Related biology news :

1. Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
2. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
3. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
4. Carnegie Mellon University research reveals how cells process large genes
5. Carnegie Mellon cyLab researchers work to develop new red tide monitoring
6. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
7. Carnegie Mellon scientists create PNA molecule with potential to build nanodevices
8. Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level
9. Carnegie Mellon scientists show brain uses optimal code for sound
10. DNA conclusive yet still controversial, Carnegie Mellon professor says
11. Teens unaware of sexually transmitted diseases until they catch one, Carnegie Mellon study finds
Post Your Comments:
(Date:10/29/2014)... a ceremony held in New York City on September ... the American Cancer Society Professor of Genome Sciences and ... 2008 Honorary Doctor of Philosophy of Tel Aviv University, ... Medical Science. , In addition to her honorary degree ... at the TAU School of Medicine, and for the ...
(Date:10/29/2014)... those referred to as ,facultative, form part—together with other ... differentiates these cells from the others. However, they have ... to become stem cells again. This phenomenon is something ... cells that stimulate tissue growth, thus allowing the regeneration ... Knowledge of the underlying mechanism that allows these ...
(Date:10/29/2014)... in the living world compete with members of ... how much they invest into their competitive ability. ... get access to high-quality resources, while others seem ... the lower-quality resources that are left over for ... and human societies seems to fluctuate considerably over ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Evolution of competitiveness 2Evolution of competitiveness 3
... other groups have created a map of the world,s ... temperatures, ultra-violet radiation, weather systems, sedimentation, as well as ... The study, say the authors, will help to ... by identifying reef systems where biodiversity is high and ...
... Viruses fill the ocean and have a significant effect ... professor of biology at UC Santa Barbara and his ... of Ecology, Evolution, and Marine Biology, is the senior ... week by the International Society for Microbial Ecology ...
... published online this week in Nature Genetics , ... with universities in China and Denmark reports the first ... type of bladder cancer. Recognizing the genetic ... healthy neighbors may allow early genetic screenings for cancer ...
Cached Biology News:Worldwide map identifies important coral reefs exposed to stress 2Worldwide map identifies important coral reefs exposed to stress 3Decade-long study reveals recurring patterns of viruses in the open ocean 2Decade-long study reveals recurring patterns of viruses in the open ocean 3University of Colorado Cancer Center genetically sequences most common bladder cancer 2
(Date:10/30/2014)... Whitehouse Laboratories has formally announced a ... and Package Test Capacity. Responding to growing demands from ... increase in environmental chamber storage space that will enable ... samples to be securely held on site at Whitehouse ... has already taken place with the recent completion of ...
(Date:10/30/2014)... CARLSBAD, Calif. , Oct. 30, 2014 Isis ... antisense therapeutics, today announced that management will present a company ... 2014 at 8:30 a.m. ET in Boston, MA. ... will be available on the "Investors & Media" section of ... available on the Isis website within 48 hours and will ...
(Date:10/30/2014)... the key challenges in the development of quantum technologies ... In a paper published today (28 October) in ... how to make a new type of flexibly designed ... as high-precision sensors and specialised superfast computers, often depend ... methods for trapping these tiny particles are hugely problematic ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... by Type (High & Medium), Sub-type (Primary & ... Processing, Infrastructure & Transportation & Power Generation) - ... the GIS market with analysis and forecasting of ... Market Data Tables with 52 Figures spread through ...
Breaking Biology Technology:Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 2Whitehouse Labs Announces Major Capital Investment in Stability and Storage Testing Capacity 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Tengion, Inc. (Nasdaq: TNGN ), a leader in ... and live audio webcast on Friday, March 25, 2011 at ... its fourth quarter 2010 financial results.   To ... (international) and reference access code 55045101. This ...
... N.J., March 18, 2011 Today, the Access Group--a ... structure; the formation of 2 business entities, Promidian and ... senior executive team leaders. The Access ... health care and life sciences industries to provide full-service ...
... 17, 2011 Quest Diagnostics Incorporated (NYSE: ... announced that its ColoVantage test has been approved by ... of patients in the state. It is believed to ... a venal blood specimen to be approved by the ...
Cached Biology Technology:Tengion To Host Conference Call To Provide a Business Update and Report Fourth Quarter 2010 Financial Results on March 25, 2011 2Introducing the Access Group and Its New Business Entities 2Introducing the Access Group and Its New Business Entities 3Introducing the Access Group and Its New Business Entities 4Introducing the Access Group and Its New Business Entities 5Introducing the Access Group and Its New Business Entities 6New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 2New York State Approves the Quest Diagnostics ColoVantage™ Colorectal Cancer Blood Test 3
... The DNA Engine Dyad instrument is the ... Featuring MJ's world-class thermal performance, the ... display, as well as point-and-click navigation via ... Dyad can be easily and economically expanded ...
... Tetrad 2 thermal cycler is a completely ... Tetrad chassis, and it accepts the full ... delivers the same precision in thermal performance ... Tetrad thermal cyclers, allowing easy transport of ...
ID clarifier: platform...
... Tetrad 2 thermal cycler accommodates a ... heat-pump assemblies), which hold different types ... computer drives an advanced graphical interface ... lid temperatures. Peltier heat pumps, built ...
Biology Products: