Navigation Links
Carbon nanotube absorption measured in worms, cancer cells

University of Michigan researchers have discovered how to measure the absorption of multi-walled carbon nanoparticles into worms and cancer cells, a breakthrough that will revolutionize scientists' understanding of how the particles impact the living environment.

A team led by U-M chemical engineering professor Walter J. Weber Jr. tagged multi-walled carbon nanotubes---one of the most promising nanomaterials developed to date---with the carbon-14 radioactive isotope, which enabled the nanotubes to be tracked and quantified as they were absorbed into living cells. Researchers used cancer cells called HeLa cells, and also measured nanotube uptake in an earthworm and an aquatic type of worm.

The findings were presented Sunday at the 231st American Chemical Society National Meeting in Atlanta. Co-authors of the presentation are graduate student Elijah Petersen and postdoctoral research assistant Qingguo Huang.

Carbon nanotubes were discovered in 1991, and hold great promise in several areas, including pharmacology and for hydrogen storage in fuel cells, Weber said. But despite their promise, a big problem is that it's not known how multi-walled carbon nanotubes will impact the living environment, Weber said.

"While everyone is concerned about this issue, there has been no really adequate way before this development to examine the extent to which they may get into human cells, and what will result if they do," Weber said. "Nobody has been able to do quantitative research on this because no method to measure them has existed until now. We were able to detect them, but had no way to determine how much was there."

In tagging the nanotubes with the isotope, researchers found that about 74 percent of the nanotubes added to a culture of cancer cells were assimilated by the cells after 15 minutes, and 89 percent of nanotubes assimilated after six hours, according to the paper. And the uptake was nearly irreversible, with only about 0.5 percent of the nanotubes releases from the cell after 12 hours.

It's important to understand if and how the multi-walled carbon nanotubes accumulate in living cells, because before the materials can become widely used in society scientists must understand if they'll pass through the food webs and possibly threaten the health of ecosystems and lead to uptake by humans, Petersen said.

"This approach has virtually limitless potential for facilitating important future investigations of the behaviors of carbon nanotubes in environmental and biomedical applications," Petersen said.


'"/>

Source:University of Michigan


Related biology news :

1. Carbon nanotubes that detect disease-causing mutations developed by Pitt researcher
2. Carbon cycle was already disrupted millions of years ago
3. Gadonanotubes greatly outperform existing MRI contrast agents
4. Modifications render carbon nanotubes nontoxic
5. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
6. Detection of DNA on nanotubes offers new sensing, sequencing technologies
7. Stable polymer nanotubes may have a biotech future
8. Pure carbon nanotubes pass first in vivo test
9. Motorola researchers develop selective sensors based on carbon nanotubes
10. Neural networking nanotubes
11. Cells selectively absorb short nanotubes
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... 27, 2016 Research and Markets has announced ... report to their offering. ... to grow at a CAGR of 12.28% during the ... on an in-depth market analysis with inputs from industry experts. The ... coming years. The report also includes a discussion of the key ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
Breaking Biology News(10 mins):
(Date:11/30/2016)... and BEIJING , Nov. ... leading commercial provider of genomic services and solutions with ... today that it has completed a USD $75 Million ... Bank Co., Ltd.,s CMB International Capital Management ( ... Investment Management Co., Ltd. ("SDIC Innovation") and Shanghai Sigma ...
(Date:11/30/2016)... November 30, 2016 Part of 5m$ ... ... Aptuit, LLC today announced that it had successfully ... 150,000 novel compounds have increased the Screening Collection to over ... hit discovery capabilities of the company. This expansion, complemented by ...
(Date:11/30/2016)... (PRWEB) , ... November 30, 2016 , ... SSCI, the ... to discuss the implications of the latest FDA guidance on pharmaceutical cocrystals as ... 2016 in Cambridge, MA. , The event follows the successful November 15th ...
(Date:11/30/2016)... ... November 30, 2016 , ... T3D Therapeutics, Inc., a clinical ... treatment for Alzheimer’s disease (AD), today announced that CEO, John Didsbury, will be ... T3D-959 in mild to moderate Alzheimer’s patients at CTAD 2016. Preliminary results of ...
Breaking Biology Technology: