Navigation Links
Candida albicans Genome Fully Annotated

Circulating stem cells play a minor role in repairing lung damage, according to a team of scientists who used male and female chromosomal differences to analyze the repair process in lung transplant patients.

Reporting in today's edition of the journal Transplantation, lead author Dani Zander, M.D., of The University of Texas Medical School at Houston, and colleagues at the University of Florida College of Medicine found that less than 1 percent of a certain type of reparative lung stem cell originated in the bone marrow of the transplant recipient.

"It's possible in the future that circulating stem cells could be augmented to play a greater role in lung repair ?and people are looking at ways to do that. We found that the bulk of stem cell contribution to the repair process belongs to those stem cells normally found in the lungs rather than to circulating stem cells," said Zander, who is professor and vice chair of pathology and laboratory medicine.

Stem cells are produced during adulthood in the bone marrow, where some remain while others circulate in the blood stream. Their main function is to produce all of the elements of blood. Some studies show that circulating stem cells are capable of diffentiating into other types of tissue, including lung tissue, Zander said, and this study provides evidence of differentiation.

Researchers examined lung biopsy specimens from seven male transplant recipients who had received lungs from female donors. They analyzed the origins of type II pneumocytes, a stem cell involved in the complex processes of lung repair, found in the lung tissue. Donor lungs come with their own type II pneumocytes, which in this case have two X chromosomes. Cells produced by the recipient's bone marrow have an X and a Y (male) chromosome.

Lung transplant recipients are vulnerable to pulmonary injury from infections, rejection of the transplanted lung, ischemia, and other factors that damage the alveoli ?tiny holl ow sacs along the airways where the blood takes in oxygen and discards carbon dioxide.

The processes by which alveoli recover from damage are complex and incompletely understood, Zander said. Previous research showed that type II pneumocytes in the lungs are known to play a central role, but the role of the bone marrow-derived version of the cells is less clear.

"The lung has received relatively little investigation in this area," Zander said. "It's a challenging organ to study because the air-tissue interfaces make it difficult to separate different cell types."

Applying advanced research techniques that previously had been used to analyze liver and bone marrow transplant recipients, the team found that nine of 25 lung tissue specimens from five recipients contained small numbers of the male gender version of the type II pneumocytes. The proportion of Y chromosome-containing pneumocytes was less than 1 percent.

They also found a statistically significant relationship between the number of Y chromosome-containing pneumocytes and the incidence of acute cellular rejection in the tissue, suggesting that stem cell repopulation might be stimulated by greater degrees of injury to the lung.

The possibility that the presence of male gender pneumocytes in female lungs might result from an earlier pregnancy with a male fetus cannot be ruled out, Zander said. However, the association between the number of those cells found in the lung tissue with damage from rejection makes that unlikely.

There was no sign of fusion between the bone marrow-derived cells and the donor pneumocytes, said Zander, who holds the Harvey S. Rosenberg, M.D., Chair in Pathology and Laboratory Medicine at the medical school and serves on the Council of the American Society of Investigative Pathology, a prestigious organization focused upon investigating mechanisms of disease. She also was awarded the Young Clinical Scientist Award this year by the Associati on of Clinical Scientists.

Study co-authors are Maher Baz and Christopher Cogle both of the Department of Medicine; Gary Visner of the Department of Pediatrics and senior author James Crawford, of the Department of Pathology, all at the University of Florida College of Medicine in Gainesville, Fla., and Neil Theise of the Department of Pathology at Beth Israel Medical Center in New York.


'"/>

Source:


Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
3. Genome-wide mouse study yields link to human leukemia
4. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
5. Multiple Campylobacter Genomes Sequenced
6. Analysis Of Human Genome To Predict The Development Of Illnesses
7. Whole genome promoter mapping - Human Genome Project v2.0?
8. Genome study of beneficial microbe may help boost plant health
9. Genome Sequence for Haemophilus Influenzae Completed
10. NHGRI Selects 13 More Organisms for Genome Sequencing
11. First Whole Genome Map of Genetic Variability in Parkinson’s Disease
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... 30, 2017 The research team of The ... (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery ... of speed and accuracy for use in identification, crime investigation, immigration ... ... A research team ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/10/2017)... , Oct. 10, 2017 SomaGenics announced ... the NIH to develop RealSeq®-SC (Single Cell), expected to ... profiling small RNAs (including microRNAs) from single cells using ... highlights the need to accelerate development of approaches to ... "New techniques for measuring levels of ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology: