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Cancer virus protein needed for successful infection

utant strain of HTLV-1 that lacked p13. The researchers then infected one batch of rabbit T cells with the mutant virus and a second batch of rabbit T cells with a strain of normal HTLV-1.

Last, they inoculated six rabbits with T cells infected with virus that lacked the p13 protein and six rabbits with T cells infected with the normal virus. (HTLV-1 spreads when an infected cell touches an uninfected cell.)

The rabbits inoculated with the virus lacking p13 remained uninfected, while all six rabbits receiving cells with normal HTLV-1 became infected.

"Our findings are the first to indicate that the HTLV-1 p13 protein plays an essential biological role during the early phase of virus infection in an animal model," Lairmore says.

Next, the researchers will study the function of p13 in HTLV-1 infection, and how it affects mitochondria.


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Source:Ohio State University


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