Navigation Links
Cancer virus protein needed for successful infection

New research shows that a protein made by a cancer-causing virus that was thought to be unimportant for its replication is in fact critically needed by the virus to initiate an infection and to reproduce.

The study examined the human T lymphotropic virus type 1 (HTLV-1) and a protein it makes called p13. The protein is one of the virus' so-called accessory proteins, proteins that earlier studies done in laboratory-grown cells suggested that the virus could live without.

But this new study ?done using an animal model that the virus can infect ?suggests that HTLV-1 needs the p13 protein to successfully infect the body and reproduce.

The research, published in the April 1 issue of the Journal of Virology, was led by scientists with The Ohio State University Cancer Program and OSU College of Veterinary Medicine.

"It is important to understand the function of these accessory molecules so we know if they should be incorporated into vaccines or targeted by new drugs as a way to prevent infection," says principal investigator Michael Lairmore, professor and chair of veterinary biosciences and a member of the OSU Comprehensive Cancer Center.

"This viral protein is also important to study because it travels to the mitochondria of infected cells." Mitochondria produce the cell's energy supply and store enzymes that carry out the process of natural cell death, or apoptosis.

"These findings should help us begin to learn whether this viral protein influences cell survival, perhaps by extending the life of the cell," Lairmore says.

HTLV-1 infects an estimated 15 to 20 million people worldwide. About 5 percent of those infected develop adult T cell leukemia or lymphoma (ATLL), an aggressive disease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, infected blood and breast milk.

For this study, Lairmore and a group of collaborators developed a m utant strain of HTLV-1 that lacked p13. The researchers then infected one batch of rabbit T cells with the mutant virus and a second batch of rabbit T cells with a strain of normal HTLV-1.

Last, they inoculated six rabbits with T cells infected with virus that lacked the p13 protein and six rabbits with T cells infected with the normal virus. (HTLV-1 spreads when an infected cell touches an uninfected cell.)

The rabbits inoculated with the virus lacking p13 remained uninfected, while all six rabbits receiving cells with normal HTLV-1 became infected.

"Our findings are the first to indicate that the HTLV-1 p13 protein plays an essential biological role during the early phase of virus infection in an animal model," Lairmore says.

Next, the researchers will study the function of p13 in HTLV-1 infection, and how it affects mitochondria.


'"/>

Source:Ohio State University


Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Bangor, Maine (PRWEB) , ... April 20, 2017 ... ... members’ contributions to the scientific and clinical research community’s growing body of knowledge ... 20, 2017 in the Gracie Theatre and the adjacent Darling Atrium. During the ...
(Date:4/20/2017)... , April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. ... new results at the International Liver Congress ("ILC") 2017 of ... in Amsterdam on the positive effects ... mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of ...
(Date:4/20/2017)... San Diego, CA (PRWEB) , ... April 20, 2017 , ... ... and management of clinical trials worldwide, announced today that they were named one of ... magazine , which covers the latest developments in the pharmaceutical industry. , “We take ...
(Date:4/20/2017)... , April 20, 2017 Dutch philosopher Koert van Mensvoort ... Nature, at the University of Technology in Eindhoven - has written a ... letter, he calls on humanity to avoid becoming a slave and victim to ... ... Dutch philosopher Koert van Mensvoort – founder of the Next ...
Breaking Biology Technology: