Navigation Links
Cancer virus protein needed for successful infection

New research shows that a protein made by a cancer-causing virus that was thought to be unimportant for its replication is in fact critically needed by the virus to initiate an infection and to reproduce.

The study examined the human T lymphotropic virus type 1 (HTLV-1) and a protein it makes called p13. The protein is one of the virus' so-called accessory proteins, proteins that earlier studies done in laboratory-grown cells suggested that the virus could live without.

But this new study ?done using an animal model that the virus can infect ?suggests that HTLV-1 needs the p13 protein to successfully infect the body and reproduce.

The research, published in the April 1 issue of the Journal of Virology, was led by scientists with The Ohio State University Cancer Program and OSU College of Veterinary Medicine.

"It is important to understand the function of these accessory molecules so we know if they should be incorporated into vaccines or targeted by new drugs as a way to prevent infection," says principal investigator Michael Lairmore, professor and chair of veterinary biosciences and a member of the OSU Comprehensive Cancer Center.

"This viral protein is also important to study because it travels to the mitochondria of infected cells." Mitochondria produce the cell's energy supply and store enzymes that carry out the process of natural cell death, or apoptosis.

"These findings should help us begin to learn whether this viral protein influences cell survival, perhaps by extending the life of the cell," Lairmore says.

HTLV-1 infects an estimated 15 to 20 million people worldwide. About 5 percent of those infected develop adult T cell leukemia or lymphoma (ATLL), an aggressive disease characterized by a long latent period and the proliferation of T lymphocytes. The virus is spread by sexual activity, infected blood and breast milk.

For this study, Lairmore and a group of collaborators developed a m utant strain of HTLV-1 that lacked p13. The researchers then infected one batch of rabbit T cells with the mutant virus and a second batch of rabbit T cells with a strain of normal HTLV-1.

Last, they inoculated six rabbits with T cells infected with virus that lacked the p13 protein and six rabbits with T cells infected with the normal virus. (HTLV-1 spreads when an infected cell touches an uninfected cell.)

The rabbits inoculated with the virus lacking p13 remained uninfected, while all six rabbits receiving cells with normal HTLV-1 became infected.

"Our findings are the first to indicate that the HTLV-1 p13 protein plays an essential biological role during the early phase of virus infection in an animal model," Lairmore says.

Next, the researchers will study the function of p13 in HTLV-1 infection, and how it affects mitochondria.


'"/>

Source:Ohio State University


Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/15/2018)... ... November 14, 2018 , ... Researchers from ... scientific evidence on gene-disease relationships and how it supports medical management decisions at ... Atlanta, November 14-17. , Ambry has been selected by NSGC to lead ...
(Date:11/13/2018)... ... November 13, 2018 , ... Drs. Richard Amato ... less invasive techniques, less discomfort and less recovery time. Serving patients in an ... bleeding gums, and bad breath, this team is reaching out to the over ...
(Date:11/13/2018)... ... 2018 , ... Kenall has enhanced the popular MedMaster MAEC Series LED luminaires ... overbed luminaires are equipped with symmetric ambient and asymmetric exam modes, and an IP65 ... to be specified in pairs, the MAEC is 8” x 48” and has a ...
Breaking Biology News(10 mins):
(Date:11/15/2018)... (PRWEB) , ... November 14, 2018 , ... ... bringing the world’s first self-learning snore-reduction mask to the public. It is estimated ... poorer quality of sleep for themselves and their partner. The resulting daytime fatigue ...
(Date:11/13/2018)... ... November 13, 2018 , ... , Park Systems, world leader in ... the increasingly growing demand for AFM technology in China, Park Systems has decided to ... an office in Beijing equipped with Park AFM. , The Grand Opening of the ...
(Date:11/9/2018)... ... November 08, 2018 , ... Superior ... and IT solutions with 140 employees on both the east and west coasts, ... the Pennsylvania Convention Center on November 14 and 15 in Philadelphia. The event ...
(Date:11/5/2018)... , ... November 05, 2018 , ... ... telemedicine company backed by Siemens Healthineers and several healthcare VC firms announces at ... solution and making a history by purchasing tokens and obtaining its first radiology ...
Breaking Biology Technology: