Navigation Links
Cancer stem cells linked to radiation resistance

Certain types of brain cancer cells, called cancer stem cells, help brain tumors to buffer themselves against radiation treatment by activating a "repair switch" that enables them to continue to grow unchecked, researchers at Duke University Medical Center have found.

The researchers also identified a method that appears to block the cells' ability to activate the repair switch following radiation treatment. This finding may lead to the development of therapies for overcoming radiation resistance in brain cancer as well as other types of cancer, the researchers said.

Working with animal and cell culture models, the researchers found that a specific cellular process called the "DNA damage checkpoint response" appears to enable cancer stem cells to survive exposure to radiation and to switch on a signal to automatically repair any damage caused to their DNA.

"In recent years, people have hypothesized that cancer stem cells are responsible for the resistance of malignant tumors to radiation treatment," said Jeremy Rich, M.D., senior investigator of the study and an associate professor of neurology at Duke. "We have shown, for the first time, that this is indeed the case."

The findings appear Oct. 18, 2006, in the advance online edition of the journal Nature. The research was supported by the National Institutes of Health and a number of philanthropic organizations [complete list below].

The type of cancer that the researchers studied, glioblastoma, is highly resistant to radiation and other forms of treatment and is the most deadly form of brain cancer worldwide. Although aggressive treatments can destroy the majority of the cancerous cells, a small fraction of them remain and often regenerate into even larger masses of tumor cells.

Until recently, scientists knew little about what made these resistant cells different from those that succumb to radiation treatment. It was clear, however, that the cells shared cha
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer stem cells linked radiation resistance

(Date:7/11/2014)... fire started near the City of Entiat on Tuesday, ... the fire quickly grew to over 1,000 acres by ... fire is under investigation by the Washington Department of ... existing local resources in developing fire control strategies and ... Washington State Department of Natural Resources, (WA DNR), Bureau ...
(Date:7/11/2014)... a new professorship in tissue engineering to promote ... Engineering and the Marine Biological Laboratory, supported by ... Eugene Bell Foundation., The Eugene Bell Professorship in ... Molecular Engineering. That endowed chair holder also will ... Bell Center for Regenerative Biology and Tissue Engineering, ...
(Date:7/11/2014)... TRAP" to capture the early signs of kidney failure, ... Journal of Clinical Investigation . Their new transgenic ... cellular and genetic information from a variety of solid ... for Medical Research in 2008, TRAP involves attaching a ... the cell type of interest. Scientists can then collect ...
Breaking Biology News(10 mins):New professorship in tissue engineering links molecular engineering, marine biology 2
... 9, 2012) In a study to be presented today ... Meeting , in Dallas, Texas, researchers will report findings that ... rupture of membranes between the 34th and 37th week of ... risk of infection or respiratory problems in the newborn. ...
... Some unusual alliances are necessary for you to ... enable better treatment of neuromuscular diseases, such as myasthenia ... brain, said Dr. Lin Mei, Director of the Institute ... University. , During development, neurons in the spinal cord ...
... in rice grains conducted by researchers at the RIKEN ... 131 rice metabolites and clarified the genetic and environmental ... natural way to bioengineer improved rice grain varieties by ... value of crops. As one of the most ...
Cached Biology News:Study indicates that induced labor may not lower risk of infection or respiratory problems in newborns 2Unusual alliances enable movement 2New study sheds light on genetics of rice metabolism 2
(Date:7/14/2014)... CA (PRWEB) July 14, 2014 ... patient registry platform, announced that three PatientCrossroads-based ... dystrophies; the Phelan-McDermid Syndrome International Registry; and ... Syndrome—have been awarded contracts by the Patient-Centered ... the creation of a new health data ...
(Date:7/11/2014)... -- , Not for release, publication or distribution ... jurisdiction where to do so would constitute a violation of ... ("Shire" or the "Company") (LSE: SHP, NASDAQ: SHPG ... has held a meeting with representatives of AbbVie. ... agreement or approval of AbbVie. A further update ...
(Date:7/11/2014)... , July 11, 2014  Researchers have ... three-dimensional images. The new technology, called Virtual Finger, ... small structures like neurons and synapses using the ... unique technology makes 3D imaging studies orders of ... at an unprecedented level across many areas of ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Understanding the ... channel-expressing cell lines, and the gap that currently exists ... that expand its industry-leading portfolio of validated ion channel ... ion channel-expressing cell lines, as ion channels control many ... control this activity creates the potential to treat a ...
Breaking Biology Technology:PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3Shire plc - Statement re: Media Speculation 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3
... United,Therapeutics Corporation (Nasdaq: UTHR ) announced today ... results before market open on,Thursday, October 30, 2008., ... on Thursday,October 30, 2008, at 9:00 a.m. Eastern ... international callers dialing,1-706-679-8129. A rebroadcast of the teleconference ...
... Oct. 23 SuperGen, Inc.,(Nasdaq: SUPG ... discovery and,development of novel cancer therapies, today ... and four additional posters, at the 20th,EORTC-NCI-AACR ... in,Geneva, Switzerland. MP-470, an orally bio-available multi-targeted,tyrosine ...
... 2008) -- A study seeking possible cancer genes elucidated the ... form of lung cancer lung adenocarcinoma and could ... the Baylor College of Medicine Human Genome Sequencing Center that ... National Human Genome Research Institute. , In the report ...
Cached Biology Technology:SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 2SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 3SuperGen's MP-470 Demonstrates Clinical Tumor Regression When Combined with Standard of Care Chemotherapy 4Unraveling the genetic picture of lung cancer 2
... in an easy-to-use benchtop package. Our ... (ESI-oa-TOF) concentrates the performance of a ... fits on your bench. The microTOFLC ... FWHM and mass accuracy of better ...
... IndicationIncludes all the features of Tracker, plus software ... for a user defined period of time in ... a family of instruments all built around a ... and that can track two fields at once ...
... features of Tracker, plus software to note when ... provide a food reward.The Spatial Behavior line is ... video camera, frame grabber, and feature extraction software ... and up to 6 moving animals. Software ...
... Tracker, plus software to note when an animal ... arena, and trigger a penaltyThe Spatial Behavior line ... a video camera, frame grabber, and feature extraction ... once and up to 6 moving animals. ...
Biology Products: