Navigation Links
Cancer scientists create 'human' leukemia process to map how disease begins, progresses

Cancer researchers led by Dr. John Dick at Ontario Cancer Institute (OCI) have developed a method to convert normal human blood cells into "human" leukemia stem cells. The converted cells, when transplanted into special mice that permit the growth of human cells, can replicate the entire disease process from the very moment it begins. The findings are published in the journal Science.

Dr. Dick, Senior Scientist at OCI, the research arm of Princess Margaret Hospital, and a Professor in the Department of Molecular Genetics, University of Toronto, said: "Most human leukemia research involves studying a patient's diseased cells or a cell line grown from those cells. However, since cancer takes many months or years to develop, just studying the cells at the end of the process does not let you know what the series of changes were that caused the cells to become leukemic, and when they happened.

"With the method we developed, we have duplicated the natural process every step of the way. The method we developed opens the pathway generally to understanding the process of how cancer begins."

The scientific team of Frederic Barabe, James Kennedy and Kristin Hope introduced a specific leukemia gene into normal human stem cells and injected the genetically altered cells into mice that lacked immune systems. The result? 100% of the mice developed fatal leukemia that displayed the same characteristics and patterns of human disease.

For the past 20 years, said Dr. Dick, leukemia research has focused mainly on human cells where the disease already exists or by studying leukemia created in mouse cells. This study flipped it around to focus on asking which are the normal cells within which the disease arises and then how it evolves and progresses, all within the context of human cells.

"So what we are building is a new approach and way of studying how leukemia arises in the first place. We found that with the leukemia gene we were
'"/>

Source:Princess Margaret Hospital


Page: 1 2

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
(Date:6/18/2013)... a hacker lab. At Brandeis University, sophisticated computational ... helping scientists understand the complex interplay between genomic ... virus, outer "shell" critical for replication. ... we are finding will help researchers alter virus ... fellow Jason Perlmutter, first author of the scientific ...
(Date:6/18/2013)... June 18, 2013 Joshua Obar, Ph.D., Department of ... honored with a 2013 ICAAC Young Investigator Award for ... immunological memory responses to infection. , Obar earned ... 2001 and went on to complete his Ph.D. in ... He performed his Ph.D. thesis research in Edward Usherwood,s ...
(Date:6/18/2013)... refers to a chemical modification of DNA and ... in the DNA sequence. Until now, scientists believed ... of certain genes. Today, a team of researchers ... by Emmanouil Dermitzakis, Louis-Jeantet Professor at the Faculty ... the case and that DNA methylation may play ...
Breaking Biology News(10 mins):Computer modeling technique goes viral at Brandeis 2The American Society for Microbiology honors Joshua Obar 2The secret of DNA methylation 2
... SALT LAKE CITY, Aug. 31, 2009 Researchers at ... shed new light on Ewing,s sarcoma, an often deadly bone ... shows that patients with poor outcomes have tumors with high ... the effects of chemotherapy. The research is published online today ...
... new molecular sensor that can reveal the amount of zinc in ... including type 2 diabetes. The research, published today in Nature ... biology by giving scientists an accurate way of measuring the concentration ... Zinc is involved in many processes in the body and ...
... Manipulating tiny objects like single cells or nanosized beads often ... uses sound as a tiny tweezers can be small enough ... , , "Current methods for moving individual cells or tiny ... lot of energy and could damage or even kill live ...
Cached Biology News:New hope for deadly childhood bone cancer 2Think zinc: Molecular sensor could reveal zinc's role in diseases 2Acoustic tweezers can position tiny objects 2Acoustic tweezers can position tiny objects 3
(Date:6/18/2013)... Monmouth, NJ (PRWEB) June 18, 2013 Earlier ... the AdWords advertising platform. As this directly impacts the ... to be the one of the most sweeping updates since ... Core and More Technologies recently posted a very informative ... initially set a ‘must-have’ upgrade date for enhanced campaigns ...
(Date:6/18/2013)... UT (PRWEB) June 18, 2013 NuView ... generation imaging and in vitro diagnostic (IVD) biomarkers, today ... NuView’s novel urine screen in development for the early ... was presented in an oral presentation at the 2013 ... Molecular Imaging (SNMMI) in Vancouver, Canada on Sunday, June ...
(Date:6/17/2013)... FRANCISCO , June 17, 2013  KaloBios Pharmaceuticals, ... appointment of Donald R. Joseph as Chief ... years of biopharmaceutical industry experience and has worked in ... global health non-profit organizations. (Logo: ... successful track record as a general counsel and senior ...
(Date:6/17/2013)... zuChem Inc., a leading producer of ... today that the United States Patent and Trademark ... 8,367,346 entitled “Methods for Production of Xylitol in ... D-Mannitol." These two patents expand zuChem's technology portfolio ... products from abundant, renewable feedstocks. , The ...
Breaking Biology Technology:Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 2Core and More Technologies Helps Organizations Migrate to Google’s Enhanced Campaign Structure 3NuView Life Sciences Announces Presentation of Data for Novel Prostate and Bladder Cancer Molecular Diagnostic at SNMMI 2NuView Life Sciences Announces Presentation of Data for Novel Prostate and Bladder Cancer Molecular Diagnostic at SNMMI 3KaloBios Appoints Donald R. Joseph as Chief Legal Officer 2KaloBios Appoints Donald R. Joseph as Chief Legal Officer 3KaloBios Appoints Donald R. Joseph as Chief Legal Officer 4zuChem Receives Two Polyol Patents 2
... October 20, 2011 PharmaVentures today announced the ... Essential Deal Trends: Oncology 2011 . This ... in developing and commercialising new drugs. The first report in ... single most active deal making therapeutic area in the pharmaceutical ...
... California, Berkeley, have turned a benign virus into ... collagen, one of the most important structural proteins ... be used to manufacture materials with tunable optical, ... led by Seung-Wuk Lee, UC Berkeley associate professor ...
... LAFAYETTE, Ind. - Researchers at Purdue University and the ... a device small enough to fit on a computer ... pulses, a technology that might have applications in more ... pulses repeat at very high rates, corresponding to hundreds ...
Cached Biology Technology:Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 2Pfizer, Sanofi and Genentech Feature Prominently in the Oncology Edition of PharmaDeals' New Publication Series; Essential Deal Trends 3Researchers turn viruses into molecular Legos 2Researchers turn viruses into molecular Legos 3'Microring' device could aid in future optical technologies 2
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
Tissue culture grade....
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
IHC detection kit for PCNA in cells and tissues...
Biology Products: