Navigation Links
Cancer researchers add spice to research against rare neuromuscular disease

sease, a vital molecule known as CREB-binding protein or CBP becomes bound up or entangled by the clumps in motor neurons. This smothers CBP's normal activity which involves turning on another molecule known as VEGF, a growth factor that is crucial for life and essential to the health of motor neurons.

Chang's team found that ASC-J9 breaks up the clumps by separating the androgen receptor from some of its helper molecules, or co-factors. As the clumps dissolve, CBP moves throughout the cell as it normally would, producing more VEGF.

Ultimately, the work brought about healthier mice whose symptoms were much improved. Chang's team also found that the amount of abnormal clumps in the neurons and spinal cords of the mice was slashed by half, and that VEGF activity in the neurons went up more than four times in the treated mice compared to untreated mice.

The new research is a signal that new avenues for treating conditions like prostate cancer, baldness and Kennedy's disease ?all of which rely on the androgen receptor ?are opening up, thanks to the dozens of molecular players that Chang and others have identified in the past decade.

"Traditionally, when scientists have wanted to affect the androgen receptor, they have taken away substances like testosterone that bind to and activate the receptor," said Chang. "But this can cause many unwanted, systemic side effects. We take another approach: Instead of taking away the substances that turn on the receptor, we look for ways to attack the faulty receptor directly. In this experiment, for instance, the mice treated with ASC-J9 have normal fertility and are completely healthy sexually, which wouldn't be the case if we simply took away testosterone."


'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

Post Your Comments:
(Date:11/25/2009)... firefighters, police officers and ambulance worke...rade Center complex. They battled to save people f...vors, tackled fires and evacuated as many people a...ed 17,000 people. And making their jobs even harde...ed workers and their relatives jammed mobile netwo...
(Date:11/25/2009)...EMBER 25, 2009 Soil is the linchpin of the enviro...e meet. Despite that, many students see soil as "j...e. Soil science educators are challenged with the ...the critical importance of soil in the environment... earth science teachers at University of Nebraska-...
(Date:11/25/2009)...niversity assistant professors recently received f...to continue research beneficial to understanding t..., Christopher Blackwood, assistant professor in t...grants to support two separate research projects. ...ecomposer Communities and Functions from the Leaf ...
Breaking Biology News(10 mins):Magic box for mission impossible 2Magic box for mission impossible 3It's not just dirt! 2Kent State University professors focus research on the environment with grants totaling $890,000 2UAB researchers find TB prevention therapy is cost effective option 56588 1UAB researchers find TB prevention therapy is cost effective option 56588 2U of I acientist 3A Public policy should promote family mealtimes 56583 1U of I acientist 3A Public policy should promote family mealtimes 56583 2U of I acientist 3A Public policy should promote family mealtimes 56583 3Prototype NIST method detects and measures elusive hazards 9838 1Prototype NIST method detects and measures elusive hazards 9838 2
...and a socket, a nerve and a muscle fiber mesh at t...t al published in the Journal of Cell Biology re...laminin shapes both sides of the junction to ensur...8. , A neuromuscular junction, or synapse, in a ne...lar nerve terminal meeting a flat, oval structure ...
...t Johns Hopkins schools of Public Health and Medic...in the gene MYH9 that are associated with increase...SRD,) which is the near-loss of kidney function le...ted on the 22 chromosome, is the first gene identi... was published online September 14 in the journal ...
...ves Norman Dicks (D-WA) and Ralph Regula (R-OH) wi...ership Award at a Congressional Reception on Monda...d for their enduring support for the United States... Chairman of the House Appropriations Subcommittee... Representative Ralph Regula is former Chairman of...
Other Biology News:New gene variant identified for nondiabetic end stage renal disease in African-Americans 2USGS Coalition to honor Reps. Dicks, Regula with Leadership Award 2
(Date:11/30/2009)...ERDAM, November 30 Biopharmaceutic...first patients have been enrolled in its,multinati...e study is,designed to show reduction in transplan... an allogeneic stem cell transplantation with a mi...atients eligible for an allogeneic,stem cell trans...
(Date:11/30/2009)...lif., Nov. 30 BioMarin P...y that the Food and Drug Administration (FDA) has ...idine (3,4-DAP), amifampridine phosphate, for the ...yndrome (LEMS). 3,4-DAP has previously received o...er 2009, the Committee for Medicinal Products for ...
(Date:11/30/2009)...SHANGHAI, Nov. 30 /PRNewswire-Asia/ -- WuXi Pharma...echnology, and medical-device research and,develop...and the United States,announced that it had been ...2009 list for the fifth consecutive year. The list...ina,s technology, media, and telecommunications,in...
(Date:11/28/2009)... The Vanuatu National Advisory Committee on Cl...ommunication (SNC) Project in collaboration with t... Ltd. of New Zealand have generated preliminary cl...form the background for the country’s SNC re... on Climate Change (UNFCCC). , ...
Breaking Biology Technology:Kiadis Pharma Announces Enrollment of First Patients in a Multinational Registration Study for ATIR(TM) 2FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 2FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 3FDA Grants Orphan Drug Designation for 3,4-DAP for LEMS 4WuXi PharmaTech Named in Deloitte Technology Fast 50 China 2009 List for the Fifth Consecutive Year 2Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 2Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 3Preliminary Climate and Sea Level Changes for Vanuatu Through the Application of SimCLIM 4
...therapies have been proposed for regenerative medi...e. However, the inability of stem cells to efficie...such as muscle, skin, blood vessels, bone or neuro...his therapy. , New research shows that delivering...ls via biodegradable microspheres enhances the eff...
... Baxter Healthcare Corporation,today announced it...eld,protective coating, the first needleless intra...coating, is now available for hospitals in the,Uni... been shown to kill on,average 99.9 percent or mor...agents) known to cause catheter-related bloodstrea...
...wire-FirstCall/ - Oncolytics Biotech Inc.,("Oncoly...tive interim,results from its U.K. combination REO...in Harrington of The Institute of Cancer Research,...al, presented the results today,at The 5th Annual ... (BSGT),in Edinburgh, Scotland., Four of the firs...
Other Biology Technology:Method to deliver molecules within embryonic stem cells improves differentiation 2Method to deliver molecules within embryonic stem cells improves differentiation 3Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 2Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 3Baxter's V-Link Luer-Activated Device With VitalShield Protective Coating Now Available For Hospitals 4Oncolytics Biotech Inc. Reports Positive Interim Results of U.K. Combination REOLYSIN(R) and Carboplatin/Paclitaxel Trial 2Oncolytics Biotech Inc. Reports Positive Interim Results of U.K. Combination REOLYSIN(R) and Carboplatin/Paclitaxel Trial 3
...Microdissection (LCM) is the method of choice for ...issection is the only instrument to offer both LCM...y., UV Laser Cutting provides unprecedente...es and capturing large numbers of cells. , LCM ...
Hybridizer (220 V) from Dako
...00 System is an automated multiplexing platform th...ing SNP detection, pathogen sequence detection and...ith multiple targets can be applied to an open and...ridge, which may be reused until all tests sites h...
Bio-Plex Manager Version 3.0 to 4.0 Workstation Software Upgrade Kit from Bio-Rad
Biology Products: