Navigation Links
Cancer researchers add spice to research against rare neuromuscular disease

e than 70 co-factors are known, offering many new targets to potentially stop conditions like Kennedy's disease that involve the receptor itself.

Chang's work has led to an understanding of the genetic basis of Kennedy's disease, which affects the motor neurons that go from the spine to certain muscles, causing muscle weakness and wasting throughout body. Symptoms typically include difficulty speaking and swallowing, and weakness in the arms and legs. Patients are often diagnosed in their 30s and 40s, and while most live a normal life span, many patients end up using a wheelchair and have serious health difficulties. Currently there is no way to slow the progression or prevent the disease, which is estimated to affect a few thousand Americans, perhaps 4,000 or so.

In the experiments reported in Nature Medicine, mice carrying the human gene that were treated with ASC-J9 experienced a remarkable improvement. They were more mobile than their untreated counterparts, walking more normally and dragging their legs less often. Their muscles appeared to work normally, and they lived 40 percent longer than the untreated mice. In addition, the mice treated with ASC-J9 were able to mate and produce offspring, while their counterparts could not.

ASC-J9 appears to work by breaking up a sort of molecular clog in neurons affected by Kennedy disease. The biology of the disease is bit like Huntington's disease, a more common neurodegenerative disease that is inherited, fatal, and unyielding in its progression. Both are caused by an abnormal repeat of three nucleotides, CAG, though not in the same gene ?a kind of molecular stutter that results in extra copies of the amino acid glutamine.

In such diseases, the extra amino acids become part of abnormal proteins that clump up inside neurons, creating a clog that can bring normal molecular activity to a standstill. The clumps of material eventually become toxic to neurons.

In Kennedy's di
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
(Date:5/21/2013)... University researchers have developed a new method for ... holes in the cell surface. The technique could ... related biological fields. , Bulk electroporation a ... reversible nanopores in the cell membrane that are ... is an increasingly popular method of cell transfection. ...
(Date:5/21/2013)... an uphill battle? Try staying fit in space, where ... and bone. , That,s the challenge a group of ... three-year, $1.2 million grant from NASA. Their goal is ... missions. , "You could give astronauts the best exercise ... to stick to it, it isn,t going to help," ...
(Date:5/21/2013)... Mass. , May 21, 2013 Royal ... CX50 xMATRIX, the world,s first portable ultrasound with Philips, ... Echo (ICE) capability. The CX50 xMATRIX with available Live ... Paris at the EuroPCR, official meeting ... May 21-24. Since its launch in 2012, ...
Breaking Biology News(10 mins):Single-cell transfection tool enables added control for biological studies 2Fueling fitness on the final frontier 2Philips CX50 xMATRIX now offers world-class interventional and diagnostic features on single portable system 2
... backyard barbecue knows that hot dogs are inexplicably packaged in ... versus 10 hot dog buns. Put in ecological terms, this ... buns are worthless without hot dogs to fill them. ... where phosphorus or nitrogen limits plant production in most ecosystems. ...
... played a major role in an international scientific team ... 12 closely related fruit fly species. As well has ... to evolving immune systems -- the analysis paves the ... From the results of the research, the Cornell scientists ...
... RAND PAPER FINDS DIESEL- AND HYBRID-POWERED VEHICLES CAN ... Cars and light trucks powered by advanced diesel ... benefits than traditional gasoline-powered automobiles, according to a ... research by RAND, a non-profit research organization, also ...
Cached Biology News:At the root of nutrient limitation, ecosystems are not as different as they seem 2At the root of nutrient limitation, ecosystems are not as different as they seem 3International team compares 12 fruit fly genomes 2International team compares 12 fruit fly genomes 3RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos 2RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos 3RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos 4
(Date:5/21/2013)... of a new study led by George Washington ... that nucleation of ice in small droplets is ... behavior at the nanoscale. The formation of ice ... research question whose answer also has important implications ... The crystallization of ice from supercooled water is ...
(Date:5/21/2013)... 21, 2013 The congress of ... Association) is the biggest congress in Europe ... 10,000 participants are in Istanbul ... findings. New pioneering studies have been presented: ... (SFP) ADMINISTERED VIA HEMODIALYSATE REDUCES ESA USE" ...
(Date:5/21/2013)... 2013 Clinverse, Inc. , ... clinical trials, announced today it has formed a ... Clinverse’s ClinPay® FLS eClinical commerce platform aggregates data ... SpendMD ™, Aggregate Spend Solutions’ recently-launched flagship ... and reporting transfer of value at investigator meetings ...
(Date:5/21/2013)... 2013 According to a new ... ) "Biochip Products and Services Market (Microarrays, Reagents, Drug ... Size, Share, Growth, Trends and Forecast, 2012 - 2018," the market was ... expected to grow at a CAGR of 10.1% from ... USD 4.7 billion in 2018. Browse the ...
Breaking Biology Technology:Study led by GW professor provides better understanding of water's freezing behavior at nanoscale 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5
... First, a full disclosure: Ive been hawking the concept of ... couple of years, so its no surprise I would think its ... common ground. , ,Then again, its still something of a ... have to be a student of Wisconsin history to know that ...
... - Who needs a record label? Independent musicians can now ... and sell it five minutes later, courtesy of a new ... technology firm's Web Hosting 2.0 represents a customization expansion over ... users to host their existing Web site with Broadjam, or ...
... Doyle , noting that May 24 is the one-year anniversary ... Bush's ban on federal funding for embryonic stem cell ... , ,Doyle noted that Senate Majority Leader Bill Frist ... to schedule a vote on the Stem Cell Research Enhancement ...
Cached Biology Technology:A (modern) Tale of Two Cities: Milwaukee and Madison inch together 2A (modern) Tale of Two Cities: Milwaukee and Madison inch together 3
...
The PROTEAN II slab gel casting stand is a component of the PROTEAN II XL and xi casting apparatus. It is supplied with gaskets....
BD Falcon insert HTS 96 well, square A-bottom with lid. PET membrane, sterile. (5/ca) Packaging: 5 / pack, 5 / case ...
... pLivSelect is a direct antibiotic-based selection system ... on colony survival, eliminating the need for ... process provides close to 100% accuracy in ... platform for robot colony picking. This cloning ...
Biology Products: