Navigation Links
Cancer researchers add spice to research against rare neuromuscular disease

e than 70 co-factors are known, offering many new targets to potentially stop conditions like Kennedy's disease that involve the receptor itself.

Chang's work has led to an understanding of the genetic basis of Kennedy's disease, which affects the motor neurons that go from the spine to certain muscles, causing muscle weakness and wasting throughout body. Symptoms typically include difficulty speaking and swallowing, and weakness in the arms and legs. Patients are often diagnosed in their 30s and 40s, and while most live a normal life span, many patients end up using a wheelchair and have serious health difficulties. Currently there is no way to slow the progression or prevent the disease, which is estimated to affect a few thousand Americans, perhaps 4,000 or so.

In the experiments reported in Nature Medicine, mice carrying the human gene that were treated with ASC-J9 experienced a remarkable improvement. They were more mobile than their untreated counterparts, walking more normally and dragging their legs less often. Their muscles appeared to work normally, and they lived 40 percent longer than the untreated mice. In addition, the mice treated with ASC-J9 were able to mate and produce offspring, while their counterparts could not.

ASC-J9 appears to work by breaking up a sort of molecular clog in neurons affected by Kennedy disease. The biology of the disease is bit like Huntington's disease, a more common neurodegenerative disease that is inherited, fatal, and unyielding in its progression. Both are caused by an abnormal repeat of three nucleotides, CAG, though not in the same gene ?a kind of molecular stutter that results in extra copies of the amino acid glutamine.

In such diseases, the extra amino acids become part of abnormal proteins that clump up inside neurons, creating a clog that can bring normal molecular activity to a standstill. The clumps of material eventually become toxic to neurons.

In Kennedy's di
'"/>

Source:University of Rochester Medical Center


Page: 1 2 3 4

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
(Date:9/18/2014)... generally seem to be cheerful, happy-go-lucky characters, so you ... on life. , In fact some dogs are ... of Sydney shows. , "This research is exciting ... dogs objectively and non-invasively. It offers researchers and dog ... how that changes," said Dr Melissa Starling, from the ...
(Date:9/18/2014)... Why is it that when people are too stressed ... Researchers from the Brain Mind Institute (BMI) at EPFL ... the relationship between chronic stress and the loss of ... an enzyme attacks a synaptic regulatory molecule in the ... Nature Communications . , Carmen Sandi,s team ...
(Date:9/17/2014)... health care to reproductive technologies, the justice and ... of people to identify key issues, articulate their ... find the most defensible ways forward. But what ... societal conversations?, The Hastings Center and the Presidential ... teamed up to publish a series of essays ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3How stress tears us apart 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... percent over the last five years, according to an analysis ... analysis, completed by the Center on Hunger and Poverty at ... joined the ranks of the hungry since 1999. ... States, 2004, says that 38.2 million Americans live in households ...
... An innovative North-South research collaboration has culminated in a study ... help develop new ways to treat or prevent East Coast ... year in East and Central Africa, has had a devastating ... Kenya ?where cattle play a crucial role in the local ...
... assert Duke neuroscientists Catalin Buhusi and Warren Meck. And ... understanding all its functions. The brain's internal clocks coordinate ... movement, to getting food, they said. , In a ... Buhusi and Meck discuss the current state of understanding ...
Cached Biology News:Hunger in America rises by 43 percent over last five years 2US/African project deciphers deadly parasite genome 2US/African project deciphers deadly parasite genome 3What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock 2What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock 3What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brain's Internal Clock 4
(Date:9/18/2014)... A novel robotic system that can operate ... being tested as part of a biomedical research partnership ... the aim of determining if the robot, in conjunction ... faster, more accurate, less costly, and less discomforting for ... to deliver prostate cancer therapies with greater precision. , ...
(Date:9/18/2014)... Texas (PRWEB) September 18, 2014 ... Chancellor John Sharp, Texas A&M Health Science Center ... U.S. Department of Health and Human Services (HHS), ... dedicated a national pandemic influenza vaccine manufacturing facility ... as an anchor for the Texas A&M Biocorridor ...
(Date:9/18/2014)... Sept. 18, 2014 Research and ... "Global N-acetylcysteine Industry Report 2014" report ... N-acetylcysteine Industry Report 2014 is a professional and ... global N-acetylcysteine industry. The report provides ... classifications, applications and industry chain structure. The N-acetylcysteine ...
(Date:9/18/2014)... September 18, 2014 Leatherwood Plastics ... listed material, to stay competitive in the semiconductor, ... high-performance materials ultimately impact product quality and productivity, ... owner. , Established in 1980 in Lewisville, TX, ... many fabricators have left the business. Much of ...
Breaking Biology Technology:Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global N-acetylcysteine Industry Report 2014 2Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... 14 /PRNewswire-FirstCall/ - Aeterna Zentaris Inc. (NASDAQ: ... development company specialized in oncology and endocrine therapy, ... ("Keryx") (Nasdaq: KERX), has been granted orphan-drug designation ... for perifosine, Aeterna Zentaris, novel, potentially first-in-class, oral ...
... Mass. , July 14 Sermo ( http://sermo.com/client ... Client Center. Based on four years of client feedback and ... meets demands for enhanced navigation, mining and monitoring of organic ... million comments and nearly 4 million votes, Sermo is rich ...
... RESEARCH TRIANGLE PARK, N.C. , July 14 ... confirmed that it filed its premerger notification and report form ... the Hart-Scott-Rodino Antitrust Improvements Act of 1976 with the Federal ... of Justice on July 6, 2010 . Grifols has ...
Cached Biology Technology:Aeterna Zentaris Announces Perifosine Has Received Orphan-Drug Designation for the Treatment of Neuroblastoma 2Aeterna Zentaris Announces Perifosine Has Received Orphan-Drug Designation for the Treatment of Neuroblastoma 3Aeterna Zentaris Announces Perifosine Has Received Orphan-Drug Designation for the Treatment of Neuroblastoma 4Sermo Announces New Client Center with Advanced Mining and Monitoring of Organic Physician Dialog 2Sermo Announces New Client Center with Advanced Mining and Monitoring of Organic Physician Dialog 3