Navigation Links
Cancer cells forming blood vessels send their copper to the edge

explained, " by examining a model of angiogenesis that uses human microvascular endothelial cells to form capillary-like structures within about eight hours of being stimulated with specific growth factors. We then examined the distribution of elements in these structures by using imaging resources."

The APS played a key role in the research. The particular APS beamline Finney and her colleagues used employs specialized optics to focus coherent X-rays to sub-micrometer spot sizes, through which the sample is raster scanned (scanning from side to side, top to bottom). By collecting emitted fluorescence spectra at each point using an energy-dispersive detector, the researchers obtained images displaying the concentration and spatial distribution of many elements, including phosphorous, sulfur, iron, copper and zinc. Overlaying these elemental maps onto optical images of the cells, Finney and her colleagues then correlated elemental content with cellular structures.

"Our findings were very clear," said Finney. "We observed a dramatic relocalization of between 80 and 90 percent of cellular copper to the tips of the tendril-like projections angiogenic cells send out between one another and across the cellular membrane within the first two hours." Copper did, indeed, appear to play a special role in angiogenesis, at least on the basis of this observation.

To extend these studies to a living organism, Finney and her colleagues then examined sections of breast tumor tissue that were rich in newly formed blood vessels. "Once again," said Finney, "we found that in contrast to both non-vascularized areas and areas of mature blood vessels, in areas of tissue where blood vessels were newly invading surrounding tissue, the cells showed copper localized at the periphery of the cells and in areas immediately outside of any apparent cellular structures."

What are the implications of this discovery?

According to Finney, "These findin
'"/>

Source:DOE/Argonne National Laboratory


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer cells forming blood vessels send their copper the edge

(Date:4/8/2015)... N.C. , April 8, 2015  Infinisource, ... solutions and services, and Morpho, a leading supplier ... partnership to produce the market,s most advanced biometrically-enabled ... Infinisource,s iSolved NXG time clock is setting a ... and labor data for the small and mid-size ...
(Date:4/2/2015)... , April 2, 2015 ... DERMALOG by far outperforms the strongest competitors, showing ... high accuracy, the system is capable of a ... speed proves up to be ten times faster ... its runner-up performance.      (Photo: ...
(Date:4/2/2015)... 2015 According to preliminary estimates ... somewhat higher than 125 MSEK. This exceeds the guidance ... that revenues for Q1 2015 would be in line ... Q4 2014. The operating result for the first quarter ... interim report will as previously communicated be published on ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... SPRING HARBOR, N.Y. (Jan. 11, 2011) -- The ... a decade ago, has revolutionized biological research. But ... and linking basic biological processes to genomic information can ... new resource that provides easy access to information about ...
... One of the challenges of gene therapy - a set ... or RNA) - is to assure that this material arrives ... substantial amount along the way and without producing any undesired ... use of different types of vectors, molecules capable of transporting ...
... microscope, a coronavirus may resemble a spiny sea urchin or ... takes its name). Previously recognized as the second leading ... important diseases in many domesticated animals, a new disease form ... when the SARS coronavirus (CoV) surfaced in Asia. The ...
Cached Biology News:New user-friendly resource connects human genes to biological functions 2Nanodisk gene therapy 2New research aims to shut down viral assembly line 2New research aims to shut down viral assembly line 3New research aims to shut down viral assembly line 4New research aims to shut down viral assembly line 5
(Date:4/17/2015)... Reed Technology and Information Services ... management, preparation, and submission to the U.S. Food and ... new Lot Distribution Report (LDR) service for manufacturers of ... with the FDA’s new rule on electronic submission of ... the volume and timing of particular biologics introduced to ...
(Date:4/17/2015)... , April 17, 2015  Guggenheim Securities, the investment ... announced the hiring of William Tanner as ... Mr. Tanner will start work at Guggenheim in ... office. "Bill brings a wealth ... to our experienced and highly acclaimed healthcare team," said ...
(Date:4/17/2015)... 2015 LC Sciences LLC, a ... today that it is seeking beta testers for ... PCR based targeted sequencing technology. The system offers ... enables accurate detection of rare variants. It utilizes ... The company will collaborate with beta testers to ...
(Date:4/16/2015)... KYOTO and OSAKA, Japan ... iPS Cell Research Application (CiRA) of Kyoto University ... that they will work together to develop clinical ... such as heart failure, diabetes mellitus, neurological disorders ... iPS Cell Applications" (T-CiRA) is designed to expedite ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 2CiRA and Takeda Enter 10-year Collaboration on iPS Cell Research 3
... tools and find the organisms to break down the ... the key step toward fermentation of those sugars ... and economically efficient before cellulosic biofuels can compete with ... any exploration of systems that involve largely unknown processes, ...
... Inc. (Nasdaq: ONTY ) will conduct a conference call to discuss its ... 4:30 p.m. Eastern time ( 1:30 p.m. Pacific time ). , ... To participate in the call by telephone, ... addition, the call will be webcast live and can be accessed on the ...
... CHICAGO , July 26 Advanced ... Board: ADLS), a biopharmaceutical company engaged in the discovery, ... areas of infection, oncology and respiratory diseases, today announced ... and option agreement with The University of British ...
Cached Biology Technology:New hydrolysis model promising tool in cellulosic biofuel studies 2New hydrolysis model promising tool in cellulosic biofuel studies 3Advanced Life Sciences Expands Antibiotic Pipeline 2Advanced Life Sciences Expands Antibiotic Pipeline 3Advanced Life Sciences Expands Antibiotic Pipeline 4
... Recognizes K+ Cl- Cotransporter-1 ... no significant sequence homology ... CCC.,SPECIES REACTIVITIES: The immunogen ... in human, mouse, porcine ...
Anti-G-alpha-i 1 G-Protein Host: mouse monoclonal Species Reactivity: human, mouse, rat Applications: WB Storage: 4C...
Mouse monoclonal [DAPK-55] to DAP Kinase 1 ( Abpromise for all tested applications). entrezGeneID: 1612 SwissProtID: P53355...
KOR-1 (C-20)...
Biology Products: