Navigation Links
Cancer cells forming blood vessels send their copper to the edge

New information about a link between the growth of blood vessels critical to the spread of cancer and the copper in our bodies has been discovered by researchers from the U.S. Department of Energy's Argonne National Laboratory and the University of Chicago, using a beamline at the Advanced Photon Source.

Growing new blood vessels from existing ones ?a process called angiogenesis ?is important in growth, development and wound healing. But it also enables the spread of tumors throughout the body, so researchers have been scrambling for ways to stop angiogenesis in the fight against cancer.

One element critical to blood vessel growth is copper, a vital nutrient that plays important roles in many life processes. Compounds that reduce copper in the body without disrupting the body's normal functions can inhibit the growth of blood vessels ?and some of these compounds are even in clinical trials for use in cancer therapy. Yet, the biological basis for this sensitivity of angiogenesis to copper has been an enigma.

In search of an answer, researchers from the Biosciences and X-ray Science divisions at Argonne and the Department of Medicine, Section of Hematology/Oncology, at the University of Chicago, have used X-ray fluorescence microprobe imaging at the Advanced Photon Source at Argonne, the Western Hemisphere's most brilliant source of X-rays for research. The X-rays allowed the researchers to look at the distribution of copper in both a cell model of angiogenesis and sections of breast tumor tissue rich in blood vessels.

"We found that cells undergoing angiogenesis exhibit a distribution of their cellular copper that is distinctly different from other cells," said Argonne biologist and lead author Lydia Finney. "This discovery may help explain how copper-reducing cancer therapy works." The findings are reported in the current issue of the Proceedings of the National Academy of Sciences, or PNAS.

"We began our study," Finney
'"/>

Source:DOE/Argonne National Laboratory


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Jump-starting T Cells In Skin Cancer
3. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
4. Fox Chase Cancer Center scientists identify immune-system mutation
5. Breakthrough Microarray-based Technology for the Study of Cancer
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
8. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
9. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
10. New Breast Cancer Test Could Save Lives
11. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Cancer cells forming blood vessels send their copper the edge

(Date:5/21/2013)... device attached to a whale entangled in fishing gear, ... changed a whale,s diving and swimming behavior. The monitoring ... and migrate, depletes their energy as they drag gear ... slow death. , The scientists in this entanglement response ... two-year-old female North Atlantic right whale called Eg 3911. ...
(Date:5/21/2013)... A new analysis shows that the nation,s land ... enough algae to produce up to 25 billion gallons ... one-twelfth of the country,s yearly needs. , The findings ... that would be needed to grow significant amounts of ... were published in the May 7 issue of ...
(Date:5/21/2013)... at USC have found that a class of pharmaceuticals ... , The drugs, known as "TSPO ligands," are ... looked at the effects of TSPO ligand in young ... and in aged mice when pathology was quite severe," ... School of Gerontology. "TSPO ligand reduced measures of pathology ...
Breaking Biology News(10 mins):Study reveals how fishing gear can cause slow death of whales 2Study reveals how fishing gear can cause slow death of whales 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 4Drugs found to both prevent and treat Alzheimer's disease in mice 2
... 2010 A team led by a Scripps Research Institute scientist ... required for memory formation in Drosophila , the ... shedding light on neurological disorders such as Alzheimer,s disease or human ... 2010 edition (Vol. 67, No. 5) of the journal Neuron ...
... new Iowa State University study has found that corn bred ... of vitamin A. The discovery gives added support to the ... as an effective tool to combat vitamin A deficiency in ... vitamin A. The researchers found that the beta-carotene in the ...
... Service has designated the eastern North Pacific basking shark, ... dramatic decline in population despite decreasing fishing pressure. The ... species when there are concerns regarding the population status. ... considered for listing pursuant to the Endangered Species Act, ...
Cached Biology News:Team led by Scripps Research scientist identifies new gene for memory 2Team led by Scripps Research scientist identifies new gene for memory 3Iowa State study finds corn bred to contain beta-carotene is a good source of vitamin A 2Iowa State study finds corn bred to contain beta-carotene is a good source of vitamin A 3NOAA designates the eastern North Pacific basking shark a 'species of concern' 2
(Date:5/22/2013)... Oven Industries announces the new 5R1-1400 AC ... a PC through the TTL level UART Communication port. ... square can deliver up to 15 AMPS of load ... state relay. Operator safety is achieved with 1KV of ... sensor input. Specifications: Input Voltage 85 to 265VAC ...
(Date:5/22/2013)... 2013   Oligomerix, Inc. , a privately ... therapeutics for Alzheimer,s disease (AD) and related neurodegenerative ... B financing, which includes both issuance of new ... approximately $2.8M in new investments in the Company.  ... raise. Funding from the Series ...
(Date:5/22/2013)... , May 22, 2013  Cleveland BioLabs, Inc. (NASDAQ: CBLI) ... the Second Annual Marcum LLP Microcap Conference, May 30, in ... Neil Lyons , CPA, Chief Financial Officer ... programs on May 30 at 1:30 p.m. Eastern Time.  A ... available on the Investors page of the Cleveland BioLabs website ...
(Date:5/22/2013)... May 22, 2013 Envera announced today ... Manager. Mr. McErlean has an extensive background in ... positions throughout his career. , Mike Matheny, ... pleased to have Mike join our team”. “Mike’s background ... scale fermentation and downstream processing equipment”, added ...
Breaking Biology Technology:New AC Temperature Controller Announced by Oven Industries 2Oligomerix, Inc. Completes Series B Financing 2Oligomerix, Inc. Completes Series B Financing 3Cleveland BioLabs to Present at Second Annual Marcum LLP Microcap Conference 2Envera Appoints Michael McErlean Fermentation Manager 2
... economic motor of the European community particularly with its central ... of the U.K. and France, just north of Switzerland, Austria ... Poland, the Czech Republic and Hungary. , ,With about ... largest populations but considering its size, which is slightly ...
... days of the 1990s, it used to be that every ... foosball money could buy to launch their business. , ... than to be one so you could attract great employees ... for companies like Herman Miller, landlords, recruiters and many Web ...
... and Rogue Access Point Exposures , ,IBM ... first comprehensive intrusion detection services designed to help ... area networks. , ,IBM's wireless intrusion detection ... IBM Global Services' security and business continuity capabilities ...
Cached Biology Technology:German Life Science Oktoberfest Comes to the Midwest 2German Life Science Oktoberfest Comes to the Midwest 3German Life Science Oktoberfest Comes to the Midwest 4German Life Science Oktoberfest Comes to the Midwest 5German Life Science Oktoberfest Comes to the Midwest 6The Top 10 Musts That Should Be in Your Business Survival Kit 2The Top 10 Musts That Should Be in Your Business Survival Kit 3IBM Develops Wireless Security Service 2
High voltage electrophoresis power supply...
Mouse monoclonal antibody to ANAPC2 - anaphase promoting complex subunit 2...
... Drummond Scientific has a long ... of microinjection apparatus. Several years ago ... positive displacement microdispenser was being modified ... this unit by redesigning the microdispenser ...
... power supply (Cat. No. Minis 150VS) is ... meet most electrophoresis needs in a personal, ... 150V power supply is capable of running ... designed for individuals to have his/her own ...
Biology Products: