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Caloric restriction won't dramatically extend life span in humans: UCLA research

Severely restricting calories over decades may add a few years to a human life span, but will not enable humans to live to 125 and beyond, as many have speculated, evolutionary biologists report.

"Our message is that suffering years of misery to remain super-skinny is not going to have a big payoff in terms of a longer life," said UCLA evolutionary biologist John Phelan. "I once heard someone say caloric restriction may not make you live forever, but it sure would seem like it. Try to maintain a healthy body weight, but don't deprive yourself of all pleasure. Moderation appears to be a more sensible solution.

"With mice, if you restrict their caloric intake by 10 percent, they live longer than if they have unlimited access to food," Phelan said. "If you restrict their intake by 20 percent, they live even longer, and restrict them to 50 percent, they live longer still; but restrict their intake by 60 percent and they starve to death.

"Humans, in contrast, will not have rodent-like results from dramatically restricting calories," he said. "Caloric restriction is not a panacea. While caloric restriction is likely to be almost universal in its beneficial effects on longevity, the benefit to humans is going to be small, even if humans restrict their caloric intake substantially and over long periods of time."

Phelan developed the first mathematical model demonstrating the relationship between caloric intake and longevity, using representative data from controlled experiments with rodents, as well as published studies on humans, diet and longevity. He and Michael Rose, professor of ecology and evolutionary biology at the University of California, Irvine, published their findings in a journal article titled, "Why dietary restriction substantially increases longevity in animal models but won't in humans," published in the August issue of the peer-reviewed journal Ageing Research Reviews.

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Source:University of California - Los Angeles


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