Navigation Links
COX-2 inhibitors significantly reduce risk of cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers.

The study findings were released today at the annual meeting of the American Association for Cancer Research in Washington, D.C.

"We believe this is the first study to show that selective COX-2 inhibitors have significant chemopreventive effects against breast cancer," says Dr. Randall Harris, professor and director of the Center for Molecular Epidemiology and Environmental Health in The Ohio State University College of Medicine and lead author of the study.

The results come from a larger, case-control study of NSAID use and its impact upon the four leading types of cancer in the United States: breast, lung, prostate and colon cancer. NSAIDs are non-steroidal, anti-inflammatory drugs that block the COX-2 enzyme pathway that is often activated in inflammation, cancer, heart disease and other disorders.

Harris and his colleagues studied the use of celecoxib (Celebrex), rofecoxib (Vioxx), regular aspirin, low-dose aspirin, ibuprofen and acetaminophen among 323 women with breast cancer from 1999-2004.

They compared the results with those from a control group of 649 cancer-free women matched for age, race and county of residence.

They discovered that women who used NSAIDs on a regular basis had less breast cancer. Specifically, they found that those who used celecoxib or rofecoxib for at least two years appeared to benefit the most, experiencing a 71 percent reduction in risk of breast cancer. Ibuprofen use over the same period was associated with a 64 percent reduction, while regular aspirin offered a 51 percent reduction in risk of the disease.

On the other hand, acetaminophen, which has a negligible effect upon COX-2 activity, and low-dose aspirin provided no significant ch
'"/>

Source:Ohio State University Medical Center


Page: 1 2

Related biology news :

1. New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds
2. Anthrax inhibitors identified by Burnham team
3. Protease inhibitors reach beyond HIV
4. Enzyme inhibitors block replication of SARS virus
5. Sweet water taste paradoxically predicts sweet taste inhibitors
6. High HPV concentrations combined with smoking significantly raise risks of cervical cancer
7. Male circumcision reduces risk of HIV transmission from women to men
8. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
9. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
10. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
11. Physiological effects of reduced gravity on bacteria
Post Your Comments:
(Date:7/24/2008)... If worms could talk, they might tell potential su... that telltale come slither look. But worms send t... complex chemical code researchers are now crackin...23) in the journal Nature . , Scientists from ... California Institute of Technology and the U.S. D...
(Date:7/24/2008)...TY, Iowa The University of Iowa and Iowa State Un...tly enhance both institutions, genetic research ca...chased a massively parallel DNA sequencer an inst... rate of millions to billions of bases in a single...s will be available on a fee-for-service basis to...
(Date:7/24/2008)...A single typhoon in Taiwan buries as much carbon i...he other rains in that country all year long combi...ersity study published in a recent issue of the jo...o examine the chemistry of stream water and sedime...oon was happening at full force -- will help scien...
(Date:7/23/2008)...ck manure into a domestic renewable fuel source co...e per cent of North America,s entire consumption n...ouse gas emissions (GHGs), according to US researc...tute of Physics, Environmental Research Letters .... Emissions Benefits of Converting Manure to Biogas...
Breaking Biology News(10 mins):Mate or hibernate? That's the question worm pheromones answer 2Mate or hibernate? That's the question worm pheromones answer 3UI and ISU establish shared DNA sequencing instrumentation 2UI and ISU establish shared DNA sequencing instrumentation 3Study: Typhoons bury tons of carbon in the oceans 2Study: Typhoons bury tons of carbon in the oceans 3Study: Typhoons bury tons of carbon in the oceans 4Cow power could generate electricity for millions 2MEDIA ADVISORY 3A InfoLogix to Present at AeA Micro Cap Conference in Monterey California 18436 1MEDIA ADVISORY 3A InfoLogix to Present at AeA Micro Cap Conference in Monterey California 18436 2Mothers Pass Dangerous Toxins to Babies Through Breast Milk 18434 1New Studies Support Dermatologists Recommendation 3A Self Exams Screenings Vital for Detecting Skin Cancer 18432 1New Studies Support Dermatologists Recommendation 3A Self Exams Screenings Vital for Detecting Skin Cancer 18432 2New Studies Support Dermatologists Recommendation 3A Self Exams Screenings Vital for Detecting Skin Cancer 18432 3New Studies Support Dermatologists Recommendation 3A Self Exams Screenings Vital for Detecting Skin Cancer 18432 4New Studies Support Dermatologists Recommendation 3A Self Exams Screenings Vital for Detecting Skin Cancer 18432 5Warning 3A New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 18430 1Warning 3A New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 18430 2Warning 3A New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 18430 3Warning 3A New Skin Cancer Study Finds Outdoor Workers are Less Likely to Get Screened for Skin Cancer 18430 4
...ew York-based Wildlife Conservation Society, contr...ost-effective means of keeping potential deadly pa... The study appears in the July edition of the jour...rolling the spread of diseases afflicting both hum...billions of dollars globally. , "Few threats to gl...
... problem in Africa and understanding the factors a...f the effort to combat the disease. A new study pu...ology conducted in Western Kenya by Jacob Koella a... attracted to children with the infectious stages ...ssible forms of the disease or to uninfected peopl...
...ing and speed of gigantic, 6500-foot (2-km) thick ...n years ago could shift the blame for killing the ...h,s largest lava flows ever, with the potential of...h - if they erupted and released climate-changing ... have now identified a 600-meter (2000-foot) thick...
...e biological function of the microRNA mir1, Drs. N...School) have studied the expression profile, trans...pe of Drosophila mir-1 (Dmir-1). Mir-1 is an evolu...se and humans is limited to heart and skeletal mus...phila embryos, mir-1 expression is not required fo...
Other Biology News:Controlling wildlife trade key to preventing health crises, study says 2Mosquitoes are more attracted to individuals infected with malaria 2India's smoking gun: Dino-killing eruptions 2India's smoking gun: Dino-killing eruptions 3
(Date:7/25/2008)...ffrey Allan Will Discuss Company,s IPLEX(TM) Progr...Dystrophy, RICHMOND, Va., July 25 /PRNewswire-Fir...of follow-on biologics and biopharmaceuticals, tod...smed, will present at IBC,s,13th Annual Drug Disco...,Thursday, August 7th, 2008 at 9:25 AM ET., Dr. A...
(Date:7/25/2008)...OND, Va., July 25 /- Insmed...logics and biopharmaceuticals, today,announced tha... 8th at 8:30,AM ET, to discuss its results for the...quarterly financial results press release before t... the live conference call, please dial 866-202-197...
(Date:7/25/2008)...NG, July 25 /Xinhua-- China...q: CMED ), a leading China-based,medical device c...anced,in-vitro diagnostic products and high intens...y announced adjustment to conversion rate for the,...ble Senior Subordinated,Notes due November 2011 (t...
(Date:7/25/2008)... Real Green Goods Raises Questions... Concord, NH (PRWEB) July 25, 20...Crawford or Madonna, they,re probably sipping wate... has become a green badge of honor but, sadly, it ...d, founder and owner of Real Green Goods, a NH-bas...
Breaking Biology Technology:Insmed CEO to Present at Drug Discovery & Development Conference 2Insmed to Host Second Quarter 2008 Conference Call 2China Medical Technologies Adjusts Conversion Rate of Convertible Notes 2SIGG Water Bottles: Hip But Not Necessarily Green; Were Madonna and Cindy Crawford Hoodwinked? 2
...on, Wis. - NimbleGen Systems, Inc. , a producer ...rs to work with its advanced technology used for s...ompany has announced a number of limited-access pa...e Yale University , the University of California...,s chromatin immunoprecipitation (chIP) arrays, wh...
...on, Wis. - A United States Air Force contract to ...logy could not only provide a Madison aerospace re....9 million, it also could enable it to propel some... Laboratory has awarded $3.9 million to Orbital ...of a small launch vehicle, but it might issue addi...
...ine, Wis. - In the first partnership of its new j...ology and Innovation will market and license 10 U... International Specialty Products . , ,The joint ... in acquiring underutilized, or "off-strategy" tec...urs or existing companies in southeastern Wisconsi...
...on, Wis. - Educators at a Pennsylvania teaching a...y,s MediaSite product into their instruction to d...t disease, and other medical topics. , ,The Penn ...urchased the Web-based communications tool to reco...rums, and internal staff meetings to medical stude...
Other Biology Technology:NimbleGen partners with leading researchers 2Orbitec will use $25 million Air Force contract to make small launch vehicle 2CATI venture part of new tech-transfer strategy 2CATI venture part of new tech-transfer strategy 3
...n, without Camera • The digimage system u...It is computer free for compact space requirements...color liquid crystal display is it's specific feat...nt gels, colorimetric gels, auto radiography film,...
...odular, highly scalable, automated high throughput... 3ml industry standard SPE cartridges, the RapidTr... hours unattended. Each module can be loaded with ...ed together and controlled through a simple, easy-...
...pace saving design - ideal for personal use , Gent...gyratory action SSM3 , - See-saw wave action SSM4 ...ional tier system available to increase capacity ...ing is required, either on the bench or in incubat...
CleanBox DNA workstation with two 254nm UV lambs & 12-hr timer, 90cm (36-inch)width, single door, 115V (w/crating)
Biology Products: