Navigation Links
COX-2 inhibitors significantly reduce risk of cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers.

The study findings were released today at the annual meeting of the American Association for Cancer Research in Washington, D.C.

"We believe this is the first study to show that selective COX-2 inhibitors have significant chemopreventive effects against breast cancer," says Dr. Randall Harris, professor and director of the Center for Molecular Epidemiology and Environmental Health in The Ohio State University College of Medicine and lead author of the study.

The results come from a larger, case-control study of NSAID use and its impact upon the four leading types of cancer in the United States: breast, lung, prostate and colon cancer. NSAIDs are non-steroidal, anti-inflammatory drugs that block the COX-2 enzyme pathway that is often activated in inflammation, cancer, heart disease and other disorders.

Harris and his colleagues studied the use of celecoxib (Celebrex), rofecoxib (Vioxx), regular aspirin, low-dose aspirin, ibuprofen and acetaminophen among 323 women with breast cancer from 1999-2004.

They compared the results with those from a control group of 649 cancer-free women matched for age, race and county of residence.

They discovered that women who used NSAIDs on a regular basis had less breast cancer. Specifically, they found that those who used celecoxib or rofecoxib for at least two years appeared to benefit the most, experiencing a 71 percent reduction in risk of breast cancer. Ibuprofen use over the same period was associated with a 64 percent reduction, while regular aspirin offered a 51 percent reduction in risk of the disease.

On the other hand, acetaminophen, which has a negligible effect upon COX-2 activity, and low-dose aspirin provided no significant ch ange in the risk of breast cancer.

"The COX-2 signaling pathway is important in cancer because when it's activated, it can stimulate many key steps in cancer development, including cell division, inhibition of cell death, angiogenesis (the creation of new blood vessels to nourish growing tumors) and metastasis," says Harris, who is also a member of the OSU Comprehensive Cancer Center.

Harris says his research group is only midway through analyzing data from the other parts of the study, but adds that early results suggest that regular use of selective COX-2 inhibitors appears to provide about the same magnitude of protection from prostate, lung and colon cancer.

"These results suggest strong potential for regular use of these drugs in cancer prevention. Still, we know these drugs may have side effects, so we are not advising people to go out and start taking them until more studies confirm that they are safe and effective," says Harris.

Celebrex is still widely used for pain relief, but Vioxx was pulled off the market in 2004 following reports of heightened risk of heart attacks.

"It's clear that we need to have multiple retrospective and prospective studies to validate these findings," says Harris, who has been studying the impact of COX-2 inhibitors for many years. "Eventually, we may find that regular intake of a low dose of a COX-2 inhibitor may be enough to reset the COX-2 cascade and safely protect people against cancer."


'"/>

Source:Ohio State University Medical Center


Related biology news :

1. New understanding of COX-1 and COX-2 enzymes could revise classification of pain meds
2. Anthrax inhibitors identified by Burnham team
3. Protease inhibitors reach beyond HIV
4. Enzyme inhibitors block replication of SARS virus
5. Sweet water taste paradoxically predicts sweet taste inhibitors
6. High HPV concentrations combined with smoking significantly raise risks of cervical cancer
7. Male circumcision reduces risk of HIV transmission from women to men
8. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
9. Use of PET can reduce, may eliminate more strenuous drug development trials with animals
10. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
11. Physiological effects of reduced gravity on bacteria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... March 30, 2017 The research team of ... three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint minutiae ... realm of speed and accuracy for use in identification, crime investigation, ... cost. ... A research ...
(Date:3/29/2017)... , March 29, 2017  higi, the health IT ... North America , today announced a ... the acquisition of EveryMove. The new investment and acquisition ... of tools to transform population health activities through the ... data. higi collects and secures data today ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... ... September 20, 2017 , ... ... Huron Digital Pathology , a provider of whole slide imaging solutions, are ... conference . The workshop, entitled “Successfully Deploying a Best-in-Class Strategy for Digital Pathology,” ...
(Date:9/20/2017)... ... September 20, 2017 , ... Foresight Institute, a leading think ... technologies, announced the winners for the 2017 Foresight Institute Feynman Prizes.These are given ... manufacturing. , Established in 1993 and named in honor of pioneer physicist Richard ...
(Date:9/19/2017)... ... September 19, 2017 , ... Participants of this educational ... fume hood. Along with the advantages and disadvantages of ductless, filtered fume hoods, ... in the laboratory. , Attendees will learn from an industry expert about the ...
(Date:9/19/2017)... ... September 19, 2017 , ... The new and improved Oakton® pocket testers, ... even stand upright with a new cap design that is versatile, functional and leakproof. ... who need to test water quality. , The Oakton pocket testers have many user-friendly ...
Breaking Biology Technology: