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CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

or C. neoformans, high CO2 blocks sexual differentiation, which is known to be a key process for generating infectious spores, and the CA enzyme plays a central role in the process. Together with the accompanying work by Mühlschlegel and colleagues, this study implicates a key role for CO2 in growth and differentiation in the fungal kingdom.

The identification of a link between CO2 sensing and fungal virulence may have broad implications for the study of microbial pathogens and the role of adenylyl cyclase in virulence trait regulation by CO2. Furthermore, it may in time facilitate the development of a new class of antimicrobial agents.


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Source:Cell Press


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