Navigation Links
CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts

By using pathogenic fungi as model systems for understanding fungal diseases, two groups of researchers are reporting new work that offers insight into how carbon dioxide (CO2) governs the morphogenic changes that allow pathogenic fungi to survive in different environments and invade the human body, and they provide new evidence for how CO2 sensing and metabolism utilize evolutionarily conserved enzymes to control the growth and sexual reproduction of pathogenic microbes.

The two studies are reported by Joseph Heitman and colleagues at Duke University Medical Center and by Fritz Mühlschlegel of the University of Kent, Jochen Buck at Cornell University, and their collaborators.

How organisms sense and respond to CO2 at the cellular level is not fully understood, but it is of great importance in understanding the biology of microbes, plants, and animals alike. For example, CO2 levels govern the detection of prey by female mosquitoes, control respiration in mammals, and of course play a critical regulatory role in photosynthesis in algae and plants; in addition, CO2 sensing and transport are involved in many cellular processes and virulence attributes of diverse pathogenic bacteria and fungi--in both B. anthracis, which causes Anthrax, and C. neoformans, which causes meningitis, CO2 induces the production of sugar-based capsules that surround and protect the invading cell from the host during infection.

In their new work, Mühlschlagel and colleagues studied the function of CO2 sensing in two major human fungal pathogens, C. albicans and C. neoformans. Both cause life-threatening, invasive infections in immunocompromised patients--for example, those infected with HIV or undergoing bone-marrow transplantation. The two fungi, which are distantly related in evolution, have different attributes governing their virulence in humans. For C. albicans, a transition between different morphological forms ("yeast" and "filamentous" forms) plays a major role,
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Scientists map one of biologys critical light-sensing structures
2. Detection of DNA on nanotubes offers new sensing, sequencing technologies
3. Drug resistance may travel same path as quorum sensing
4. K-Staters design and build a low-cost remote sensing tool for environmental studies
5. Scripps Research study reveals new activation mechanism for pain sensing channel
6. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
7. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
8. Purdue proves concept of using nano-materials for drug discovery
9. FDA Approves New Drug to Treat Type I and Type II Diabetes
10. Canada approves marijuana-based pain spray
11. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
Post Your Comments:
(Date:4/8/2015)... April 8, 2015  Infinisource, a leading provider ... and Morpho, a leading supplier of biometric identification ... the market,s most advanced biometrically-enabled time clock, the ... time clock is setting a bold, new standard ... for the small and mid-size employer. When connected ...
(Date:4/2/2015)... Germany , April 2, 2015 ... fingerprint tests DERMALOG by far outperforms the strongest ... always maintaining high accuracy, the system is capable ... Hence, the speed proves up to be ten ... faster than its runner-up performance.      ...
(Date:4/2/2015)... -- According to preliminary estimates Fingerprint Cards, ... than 125 MSEK. This exceeds the guidance provided by ... for Q1 2015 would be in line with the ... The operating result for the first quarter is estimated ... will as previously communicated be published on May 21. ...
Breaking Biology News(10 mins):iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Fingerprint Cards Revises Revenues for Q1 2015 2
... through which it can protect itself against newly-developing cancer ... in our organs every day. Once tumours have developed, ... from the immune system. Scientists from the research group ... (HZI) in Braunschweig have now succeeded to reveal a ...
... in the lungs of people who smoke may offer a ... emphysema before the disease damages and eventually destroys areas of ... The study found that smokers who have very subtle signs ... different blood flow patterns in their lungs compared to non-smokers ...
... April 6, 2010 Chronix Biomedical today announced publication ... serum DNA blood tests to predict clinical status and ... sclerosis (MS). Chronix Biomedical uses proprietary technology to ... that is released into the bloodstream by damaged and ...
Cached Biology News:The immune system's guard against cancer 2The immune system's guard against cancer 3New test could identify smokers at risk of emphysema 2Chronix Biomedical's serum DNA assays monitor disease activity and treatment response in MS 2Chronix Biomedical's serum DNA assays monitor disease activity and treatment response in MS 3
(Date:5/1/2015)... , May 1, 2015 Pfenex ... engaged in the development of biosimilar therapeutics including ... today that its first quarter 2015 financial results ... before the open of market. At 8:30 am Eastern ... to discuss the financial results and provide a ...
(Date:5/1/2015)... 2015 Investor-Edge has initiated ... (NASDAQ: GENE ), Agilent Technologies Inc. (NYSE: ... TMO ), Sequenom Inc. (NASDAQ: SQNM ... Free research report on Genetic Technologies can be ... 30, 2015, the NASDAQ Composite ended at 4,941.42, ...
(Date:5/1/2015)... RESEARCH TRIANGLE PARK, N.C. , May 1, 2015 /PRNewswire/ ... Roger Jeffs , Ph.D., President and Co-Chief Executive Officer ... the company,s business at the Deutsche Bank 40 th ... . The presentation will take place on Wednesday, ... be accessed via a live webcast on the United Therapeutics ...
(Date:4/30/2015)... DIEGO , April 30, 2015   Tamir ... announced today an update on its Ebola antiviral therapy ... Tamir,s leading candidates, TMR004, is currently being evaluated and ... of the battle against Ebola. During the first quarter ... And Leadership Meeting To Accelerate The Evaluation of Potential ...
Breaking Biology Technology:Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 2Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 3Tamir Biotechnology Provides Update on TMR004 Development Against Mutating Ebola 4
... the developing world could reduce the environmental impact of ... writing today in the Inderscience publication, International Journal of ... the developing world are encouraged to compost our garden ... bin and not all of us are willing or ...
... DENVER, Sept. 18 The future of health ... integrated into practice and,health policy. But putting research ... slow the pace of cutting-edge care. Kaiser,Permanente Colorado ... aimed at getting research into practice and policy ...
... Sept. 18 Kosan Biosciences,Incorporated (Nasdaq: KOSN ) ... and Chief Financial Officer, will present at the 2007,UBS ... Grand Hyatt on,Tuesday, September 25, 2007 at 10:00 a.m. ... of the presentation by,visiting the "Events Calendar" page under ...
Cached Biology Technology:Landfill Mining 2Kaiser Permanente Colorado Opens Center for Health Dissemination and Implementation Research 2Kosan Biosciences to Present at the 2007 UBS Global Life Sciences Conference 2
... product contains 5 ml Dynabeads® ... the monoclonal BerEP4 against the ... cell adhesion molecule). Also available ... 2 x 10e7 MNC in ...
albumin from bovine serum (BSA), tetramethylrhodamine conjugate...
Superior homology search software - in all the flavours of blast, with increased sensitivity and speed...
... Processing mini Tray (3 per pack), ... staining and blot processing.Automated staining of ... proteins and nucleic acid analysis.Prepares blots ... chromogenic detection.Programmable control of protocol, solution, ...
Biology Products: