Navigation Links
CHAVI announces international search for genes affecting HIV response

A pioneering collaboration among U.S., European and Australian researchers announced June 20, 2006, will seek to identify genetic differences in the way people respond to HIV.

Through the new consortium, led by scientists at Duke University, investigators who once competed to unravel the mysteries of HIV will share access to patient groups, called cohorts, they have studied.

Support for the consortium is provided by the Center for HIV/AIDS Vaccine Immunology (CHAVI), established at Duke in 2005 with a grant that could total as much as $300 million over seven years from the U.S. National Institute of Allergy and Infectious Diseases. CHAVI's initial mission is to find out what the immune system does during HIV infection -- including in the rare individuals who control the infection on their own -- and try to produce a vaccine to mimic those responses.

"We intend to use natural genetic differences among people to point the way toward the most promising avenues for vaccine development," said David Goldstein, Ph.D., director of the Center for Population Genomics and Pharmacogenetics at the Duke Institute for Genome Sciences & Policy and director of CHAVI's host genetics research core. "We want to find out why some people naturally hold the virus down to almost undetectable levels while others lose control of it quickly."

The newly organized group, called EuroCHAVI, will recruit 600 patients from nine cohorts. "This will be is the largest cohort assembled for large-scale analysis of genetic differences among HIV-infected patients," said Amalio Telenti, M.D., Ph.D., a key organizer of the collaboration. Telenti is professor of medical virology and co-director of the Institute of Microbiology at the University of Lausanne, Switzerland.

EuroCHAVI aims to quickly identify common genes -- wherever they are in the human genome -- that affect how the body responds to HIV. "Because of the willingness of researchers throughout the world t o work together, the prospects are very real for getting answers by next year," Goldstein said.

"This is exactly the kind of work we are trying to catalyze," said CHAVI director Barton Haynes, M.D. Haynes is a professor of medicine and director of the Human Vaccine Institute at Duke University Medical Center.

Despite repeated exposures, some people apparently never become infected with HIV. Among those who become infected, there is dramatic variation in how the body responds to HIV and in how long it takes for infection to progress to AIDS. EuroCHAVI scientists will try to understand these differences by searching for an underlying genetic influence.

Typically, scientists use genetic analysis to search for minor changes in the sequence of 3 billion DNA letters that make up the human genome. The changes, called single nucleotide polymorphisms (SNPs), are like single-letter variations in the spellings of a word. The SNPs cluster in local neighborhoods, known as haplotypes, within the genome. Most of these variations are biologically meaningless, but a small fraction can alter the function of a gene. Combining the effect of many slightly altered genes may significantly increase the risk of disease -- in this case, HIV/AIDS.

The genome studies will be carried out at the Duke Institute for Genome Sciences & Policy and the University of Lausanne. "Large-scale genome analyses like this are critical for determining the role of the genome in complex diseases such as AIDS," said Huntington Willard, Ph.D., director of the Duke genomics institute. The combination of large population cohorts and state-of-the-art genome technology will allow us to dissect the genetic factors that contribute to disease."

CHAVI also will establish an even larger cohort of HIV-infected patients in Africa and perform the same genetic analyses. Haplotypes, or genetic neighborhoods, are poorly known for people of African ancestry, Goldstein said. CHAVI will f und investigators to develop a detailed and accurate map of haplotypes among these populations.


'"/>

Source:Duke University Medical Center


Related biology news :

1. Wiley announces publication of Databasing the Brain
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
4. Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer
5. GlycoFi announces the first production of antibodies with human glycosylation in yeast
6. NHGRI announces new sequencing targets
7. NHGRI announces latest sequencing targets
8. MUHC announces a transplant first in Quebec
9. St. Jude announces breakthrough in eye cancer treatment
10. NIH announces phase III clinical trial of creatine for Parkinsons disease
11. Canadian youth 4th highest in international obesity study
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/27/2017)... --  Strategic Cyber Ventures , the industry,s first cybersecurity ... million investment in  Polarity , the first commercial human ... based and is led by cybersecurity veterans Tom ... Gula , also a longtime cybersecurity veteran and founder ... A round of funding. This new funding will be ...
(Date:2/21/2017)... and PORTLAND, Ore. , Feb. ... the Avamere Family of Companies (Avamere Health Services, Infinity ... a six-month research study that will apply the power ... at senior living and health centers. By analyzing data ... to gain insights into physical and environmental conditions, and ...
(Date:2/13/2017)... Feb. 13, 2017  RSA Conference -- RSA, a ... is designed to enhance fraud detection and investigation ... the RSA Fraud & Risk Intelligence Suite. The ... leverage additional insights from internal and external sources ... protect their customers from targeted cybercrime attacks. ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a major research ... GSK to generate genetic sequence data from the 500,000 volunteer ... researchers to gain valuable insights to support advances in the ... and life threatening diseases. ... Genetic evidence has revolutionized scientific discovery ...
(Date:3/22/2017)... 2017 Good Start Genetics, a leading family ... 130 million covered lives mark through its most recent ... Texas . With newly signed contracts nationally and ... strong payor acceptance based on the quality of its ... counseling, its industry-leading customer care and support and its ...
(Date:3/22/2017)... 22, 2017 MarketNewsUpdates.com News Commentary  ... The traditional ... being pressured as of late due to the rise of ... has a dramatic impact on patient,s quality of life as ... for identifying new forms of opioid formulations that prevent abuse. ...
(Date:3/22/2017)... ... March 21, 2017 , ... Premier executive recruitment firm, Slone Partners, is proud ... Hunt Scanlon Media. , Hunt Scanlon Media is one of the most ... news source in the human capital sector. , “It is a great honor for ...
Breaking Biology Technology: