Navigation Links
C-myc required by the immune system

c-myc, a gene commonly involved in cancer onset, has been found to have a role in the immune system's normal function according to a study published today in Blood. The surprising finding, by a Swiss research team led by investigators from the Lausanne Branch of the international Ludwig Institute for Cancer Research (LICR), showed that c-myc functions in the immune system's 'memory' of previous infections.

In order to rapidly and efficiently respond to new infections, the immune system evolved such that it stores a 'memory' of previous attack by pathogens. The specialized cells involved in this process are known as 'T memory cells'. The T memory cells are normally maintained at a low level that can be rapidly expanded if the pathogen is detected again. The maintenance of normal, low levels, or 'homeostasis', of T memory cells is dependent on a signalling factor, a so-called cytokine, known as 'IL- 15.

"Very little is known about the signalling pathways that actually control IL-15-dependent homeostasis," explains LICR's Dr. H. Robson MacDonald, the senior author of the study. "By analyzing genetically engineered mouse models with reduced c-myc, reduced IL-15 or absent IL-15, we discovered that it's actually c-myc, which is known primarily as an oncogene, that acts downstream of the IL-15 signaling pathway to regulate T memory cell homeostasis."

According to Dr. MacDonald, the study is basic research that may have implications for therapies of the future. "Understanding how immune memory works might allow us to improve therapeutic vaccines against, say, malaria or cancer. The unexpected finding is that this study is also a cautionary tale. Before we design new therapies that inactivate a gene product, which is an approach being considered for c-myc in cancer, we need to be very sure that we are not going to be also destroying a vital role in a normal process such as the body's immune system."


'"/>

Source:Ludwig Institute for Cancer Research


Page: 1

Related biology news :

1. Gene variations explain drug dose required to control seizures
2. B cells are required for development of epithelial cancer associated with chronic inflammation
3. Malignant melanoma cells secrete protein required for embryo formation
4. New study reveals signaling pathways required for expansion of pancreas stem cells
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Genetically modified natural killer immune cells attack, kill leukemia cells
7. Studies reveal methods viruses use to sidestep immune system
8. Jumping gene helps explain immune systems abilities
9. Scientists solve structure of key protein in innate immune response
10. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... VILNIUS, Lithuania , March 21, 2017 /PRNewswire/ ... identification and object recognition technologies, today announced the ... development kit (SDK), which provides improved facial recognition ... safety cameras on a single computer. The new ... algorithms to improve accuracy, and it utilizes a ...
(Date:3/20/2017)... HANOVER, Germany , March 20, 2017 At ... Hamburg -based biometrics manufacturer DERMALOG. The Chancellor came to the ... Japan is this year,s CeBIT partner country. At the largest ... important biometrics in use: fingerprint, face and iris recognition as well as ... ...
(Date:3/13/2017)... March 13, 2017 Future of security: Biometric Face Matching ... ... DERMALOGs Face Matching enables to match face pictures against each ... to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face Matching on ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... ... Clinical Supplies Management (“CSM”), a Great Point Partners II (“GPP”) portfolio company, ... has doubled in size over the past six months with the acquisition of businesses ... joins CSM as Chief Financial Officer. Roger has over 25 years of experience ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... stress expertise, and further enhances its scientific power by providing investigators access ... Ph.D., has agreed to join the scientific advisory board. “We are committed ...
(Date:5/18/2017)... ... May 17, 2017 , ... USDM Life Sciences ... the life sciences and healthcare industries, is honored that Jay Crowley ... conference in Brussels, Belgium. , Crowley played a crucial role in the development ...
(Date:5/18/2017)... ... May 17, 2017 , ... ... today that their Chief Executive Officer, Maik Jornitz, was recognized as a Top ... Power List celebrates 100 individuals “involved in bettering the pharma industry and bringing ...
Breaking Biology Technology: