Navigation Links
C-myc required by the immune system

c-myc, a gene commonly involved in cancer onset, has been found to have a role in the immune system's normal function according to a study published today in Blood. The surprising finding, by a Swiss research team led by investigators from the Lausanne Branch of the international Ludwig Institute for Cancer Research (LICR), showed that c-myc functions in the immune system's 'memory' of previous infections.

In order to rapidly and efficiently respond to new infections, the immune system evolved such that it stores a 'memory' of previous attack by pathogens. The specialized cells involved in this process are known as 'T memory cells'. The T memory cells are normally maintained at a low level that can be rapidly expanded if the pathogen is detected again. The maintenance of normal, low levels, or 'homeostasis', of T memory cells is dependent on a signalling factor, a so-called cytokine, known as 'IL- 15.

"Very little is known about the signalling pathways that actually control IL-15-dependent homeostasis," explains LICR's Dr. H. Robson MacDonald, the senior author of the study. "By analyzing genetically engineered mouse models with reduced c-myc, reduced IL-15 or absent IL-15, we discovered that it's actually c-myc, which is known primarily as an oncogene, that acts downstream of the IL-15 signaling pathway to regulate T memory cell homeostasis."

According to Dr. MacDonald, the study is basic research that may have implications for therapies of the future. "Understanding how immune memory works might allow us to improve therapeutic vaccines against, say, malaria or cancer. The unexpected finding is that this study is also a cautionary tale. Before we design new therapies that inactivate a gene product, which is an approach being considered for c-myc in cancer, we need to be very sure that we are not going to be also destroying a vital role in a normal process such as the body's immune system."


'"/>

Source:Ludwig Institute for Cancer Research


Page: 1

Related biology news :

1. Gene variations explain drug dose required to control seizures
2. B cells are required for development of epithelial cancer associated with chronic inflammation
3. Malignant melanoma cells secrete protein required for embryo formation
4. New study reveals signaling pathways required for expansion of pancreas stem cells
5. Fox Chase Cancer Center scientists identify immune-system mutation
6. Genetically modified natural killer immune cells attack, kill leukemia cells
7. Studies reveal methods viruses use to sidestep immune system
8. Jumping gene helps explain immune systems abilities
9. Scientists solve structure of key protein in innate immune response
10. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2016)... 11, 2016 --> ... report "Image Recognition Market by Technology (Pattern Recognition), by ... by Deployment Type (On-Premises and Cloud), by Industry Vertical ... by MarketsandMarkets, the global market is expected to grow ... Billion by 2020, at a CAGR of 19.1%. ...
(Date:3/10/2016)... --  Unisys Corporation (NYSE: UIS ) today announced ... testing its biometric identity solution at the Otay Mesa border ... identify certain non-U.S. citizens leaving the country. ... determine the efficiency and accuracy of using biometric technologies in ... until May 2016. --> the United States ...
(Date:3/9/2016)... Nigeria . Recently, ... 23,000 public service employees either did not exist with ... unlawfully.    --> Nigeria . ... than 23,000 public service employees either did not exist ... salary unlawfully.    --> DERMALOG, the biometrics ...
Breaking Biology News(10 mins):
(Date:5/4/2016)... Diego, CA (PRWEB) , ... May 04, 2016 ... ... Day? Well, look no further than LaJollaCooks4u, San Diego’s premiere hands-on cooking experience. ... you need to give mom an experience she won’t forget. , Guests that ...
(Date:5/4/2016)... Missouri (PRWEB) , ... May 04, 2016 , ... PBI-Gordon ... Professional and Agricultural Sales. , Doug began his career at PBI-Gordon in February ... served in a wide variety of roles, ranging from customer service to national product ...
(Date:5/3/2016)... ... May 03, 2016 , ... Leading CEOs from biotech, pharmaceutical, ... and June 1st at The Four Seasons Hotel Boston. , The Boston CEO ... offering exclusive access to key decision makers who influence deal making and investment. ...
(Date:5/3/2016)... May 3, 2016  Dr. Thomas P. McHugh ... The Woodlands, Texas , now offers ... of treated fat cells in just 25-minutes, leaving a ... 90 percent of Americans report feeling bothered by excess ... reduction procedures are a growing industry. This innovative new ...
Breaking Biology Technology: