Navigation Links
Buildup of damaged DNA in cells drives aging

es currently favored in the field of aging research about why we get old, according to the authors. The first is that our lifespan and how well we age is determined by the genes inherited from our parents. The second is that lifespan and fitness in old age is determined by how much damage we incur over our lifetime.

"Our study suggests that both of these hypotheses are correct. Damage, including DNA damage, drives the functional decline we all experience as we age. But how we respond to that damage is determined genetically, in particular by genes that regulate the growth hormone and insulin pathways," said Laura Niedernhofer, M.D., Ph.D., assistant professor of molecular genetics and biochemistry, University of Pittsburgh School of Medicine, and first author of the study.

How the researchers came to study the relationship between DNA damage and aging began almost serendipitously in the late 1990s while Dr. Niedernhofer was a post-doctoral fellow in Dr. Hoeijmakers?laboratory at Erasmus Medical Center, a well-known European center for medical genetics, including the diagnosis of people with unusual sensitivity to sunlight.

A German physician had contacted the center about a 15-year old Afghan boy who was highly sensitive to the sun and had other debilitating symptoms including weight loss, muscle wasting, hearing loss, visual impairment, anemia, hypertension and kidney failure. The boy’s family had immigrated to Germany to seek better medical treatment for his condition.

Extreme sensitivity to ultraviolet (UV) radiation from sunlight is a hallmark of diseases caused by defective DNA repair—an important mechanism by which skin and other cell types normally cut out, or excise, damage to their DNA caused by UV light. Defects in one DNA repair mechanism, nucleotide excision repair (NER), causes xeroderma pigmentosum, a rare disease in which people have a 2,000-fold increased risk of skin cancer from sun exposure.

When
'"/>

Source:University of Pittsburgh Medical Center


Page: 1 2 3 4

Related biology news :

1. Tsunami-damaged coral reefs should be left to recover naturally, say scientists
2. Logging changed ecological balance for monkeys, damaged health
3. New study finds how cells with damaged DNA alert the immune system
4. Scientists get first glimpse at how plants, most animals repair UV-damaged DNA
5. Science finds new fix for UV-damaged skin in arthritis treatment
6. Adult stem cell research at UB targets damaged hearts
7. Global warming may have damaged coral reefs forever
8. Bioengineered tissue implants regenerate damaged knee cartilage
9. Gene therapy accelerates healing of damaged skeletal muscle
10. Lungs try to repair damaged elastic fibers
11. Stem cell therapy shows promise in regenerating damaged muscle in heart attack patients
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Buildup damaged DNA cells drives aging

(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2The Global Watermarking and Fingerprinting Markets 2
... National Human Genome Center at Shanghai (South Center, hereafter) ... District in Shanghai. To commemorate this important event, ,which ... we specially organize a series of mini-reviews for ,this ... the attention of the Chinese life science research workers ...
... world,s premier science and technology news magazines, released its list ... projects involving physicists from Louisiana Tech University in its Top ... over 5,000 scientists and engineers from 26 nations, ranked #2 ... Markus Wobisch led a team from Louisiana Tech that is ...
... MEETING HIGHLIGHTS BREAKTHROUGH RESEARCH IN UNDERSTANDING GENETIC AND ... Although racial and ethnic differences in ... known, little is understood about the underlying causes ... seemingly intractable problem. The American Association for Cancer ...
Cached Biology News:Human genomics in China 2Human genomics in China 3Human genomics in China 4Human genomics in China 5Human genomics in China 6Human genomics in China 7Human genomics in China 8Human genomics in China 9Human genomics in China 10Human genomics in China 11Louisiana Tech physicists highlight top 10 science stories of 2008 2American Association for Cancer Research hosts Science of Health Care Disparities Meeting 2
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application and ... manufacturing process, and product cost structure. Production is ... also covers upstream raw materials, equipment, downstream client ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... Pulmo BioTech Inc. (OTC Bulletin Board: PLMO; Frankfort ... receive at least $3.3 million pursuant to the ... letter of intent with Biotechnology Consulting Poland Sp. ... Product Candidate PulmoBind(TM) development work, clinical trials and ...
... produced liver cells from adult skin cells using the induced ... the University of Edinburgh,s MRC Centre for Regenerative Medicine, paves ... that can be used for in vitro hepatic disease models. ... cell type used in predictive drug toxicology. These cells are ...
... The scientists and engineers who introduced the world ... the next level of friendly competition designed to ... operations of useful robots whose dimensions are measured ... National Institute of Standards and Technology (NIST), in ...
Cached Biology Technology:Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 2Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 3Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 4Scientists develop novel method to generate functional hepatocytes for drug testing 2Is your microrobot up for the (NIST) challenge? 2
Imject Freund's Incomplete Adjuvant (FIA)...
... XL extends the MSn performance of the ... tools to generate extensive structural information for ... , Multiple dissociation techniques (PQD, ETD, ... unpredicted metabolites , Fast polarity switching for ...
... effective - Utilizes hands-off homogenization through a vortex ... grinding - Extract DNA without hand grinding; eliminating ... , Robust tubes - Includes tough ... tube breakage , Flexible format - ...
... The LXQ linear ion trap mass ... paced analytical laboratory., The LXQ linear ion ... discovery and proteomic applications, delivering the fast ... Thermo linear ion trap at an attractive ...
Biology Products: