Navigation Links
Building a human kinase gene repository

Using the human genome sequence annotation, high-throughput cloning methodologies, and automation, a group at the Harvard Institute of Proteomics lead by Leonardo Brizuela (Harvard Medical School lecturer on biological chemistry and molecular pharmacology) mined public databases to collect the sequence information of all identified human kinase genes and have built a gene repository for this gene class. Their work is described in the online early edition of Proceedings of the National Academy of Sciences and demonstrates uses of the collection in cellular and biochemical assays.

Kinases are an important class of enzymes that catalyze the phosphorylation of proteins, lipids, sugars, nucleosides, and other cellular components. They play key regulatory roles in all aspects of eukaryotic cell physiology and their deregulation is associated with a number of pathological conditions, which make kinases key targets in drug discovery efforts, primarily in oncology.

This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-length, and can be sub-cloned by recombination based methodologies. This gene collection will be a useful resource for the scientific community and will facilitate high-throughput cellular and biochemical assays and structural studies of this important gene family.


'"/>

Source:Harvard Medical School


Page: 1

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Building a protein name dictionary from full text: a machine learning term extraction approach
3. Building a better mouse model of lung cancer: FHIT counts
4. Protein folding: Building a strong foundation
5. Novel technology detects human DNA mutations
6. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
7. UWs Rosetta software to unlock secrets of many human proteins
8. Genome-wide mouse study yields link to human leukemia
9. Found: Missing sequence of the human Y chromosome
10. Study finds more than one-third of human genome regulated by RNA
11. Molecular machine may lead to new drugs to combat human diseases
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2016)... RESTON, Va. , Feb. 2, 2016 /PRNewswire/ ... contract award from the U.S. Army Research Office ... extend the range and sensitivity of the company,s ... DoD,s Past Accounting Mission and, more generally, defense-related ... its DNA phenotyping capabilities (predicting appearance and ancestry ...
(Date:2/1/2016)... NEW YORK , Feb. 1, 2016  Today, ... Heart Association (AHA) announced plans to develop a first ... cognitive computing power of IBM Watson. In the first ... disease, AHA, IBM (NYSE: IBM ), and Welltok ... metrics and health assessments with cognitive analytics, delivered on ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
Breaking Biology News(10 mins):
(Date:2/12/2016)... , February 12, 2016 ... Efforts by Enabling Scientific Understanding of Complex Diseases ... Rare Diseases --> ... diagnostics in South Asia and a leading provider of ... contribute $10 million to the GenomeAsia 100K consortium ...
(Date:2/11/2016)... Germany and GERMANTOWN, ... QGEN ; Frankfurt Prime Standard: QIA) today announced ... RNA Panels for gene expression profiling, expanding QIAGEN,s portfolio ... The panels enable researchers to select from over 20,000 ... and discover interactions between genes, cellular phenotypes and disease ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... cutting-edge information focused on the development and manufacture of biopharmaceuticals and therapeutics, ... sponsor of the 2016 BioProcess International Awards – Recognizing Excellence in the ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... than 150 years, continues today to pursue the highest level of accuracy and ... instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough ...
Breaking Biology Technology: