Navigation Links
Building a better mouse model of lung cancer: FHIT counts

inal cord, adrenal gland and other parts of the body.

The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke but also in beer, fish meal and some preserved meats. They discovered that when the VHL gene was missing as well, the mice were even more susceptible to tumor growth. "We thought this was interesting because this is the first indication that loss of just one of the two copies of the VHL gene could contribute to the development of cancer," says Huebner, noting that loss of one copy of the VHL gene occurs in several types of human lung cancer.

Huebner says there is still plenty of room for improvement in their new mouse model. There are several other genes on chromosome 3 that are also lost in many human lung cancers, and incorporating deficiencies in those genes with the current model will only make it stronger, she says, adding they're already working on it.

Other Ohio State researchers who contributed to the study include Nicola Zanesi, adjunct assistant professor and research scientist, George Calin, adjunct assistant professor, and Yuri Pekarsky, assistant professor, all in the department of molecular virology, immunology and medical genetics; Rita Mancini, post-doctoral researcher, and Mohamed Kaou, research associate, in the OSUCCC, and Carlo Croce, professor and chair of the department of molecular virology, immunology and medical genetics.


'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Building a human kinase gene repository
3. Building a protein name dictionary from full text: a machine learning term extraction approach
4. Protein folding: Building a strong foundation
5. Chemists create Superbowl molecule; May lead to better health
6. Protein discovery could unlock the secret to better TB treatment
7. Signaling protein builds bigger, better bones in mice
8. Harnessing microbes, one by one, to build a better nanoworld
9. Two are better than one
10. Discovery may lead to better Candidiasis drug
11. Insects, viruses could hold key for better human teamwork in disasters
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Building better mouse model lung cancer FHIT counts

(Date:7/31/2014)... the United States, natural-gas production from shale rock ... 2007. Yet scientists still do not fully understand ... to a report in the journal Frontiers ... gas extraction continues to vastly outpace scientific examination, ... organizations and institutions, including Princeton University, concluded that ...
(Date:7/31/2014)... Foundation (NSF), counters a widely-held scientific view that ... that certain Arctic lakes store more greenhouse gases ... The study, published this week in the journal ... occur as permafrost thaws and creates surface depressions ... was previously frozen land into lakes. , The ...
(Date:7/31/2014)... long been known that biomass burning burning ... a ritual , slash-and-burn agriculture and wildfires ... , But until the release of a new ... Professor Mark Z. Jacobson, the degree of that ... research, detailed in a paper published July 30 ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3Certain Arctic lakes store more greenhouse gases than they release 2Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4
... kid goats recognise each other,s calls soon after the mothers ... reveals. The study, published in the journal Animal ... the ability of goats to recognise the individual differences. ... Mary,s School of Biological and Chemical Sciences found that mother ...
... smoke flavoring made from hickory and other wood a ... and home kitchens may get a competitor that seems ... to a new study in ACS, Journal of Agricultural ... liquid smoke produced from rice hulls, the hard, inedible coverings ...
... For diagnosing head and neck ailments, tests that ... don,t. Otolaryngologists have a wide range of techniques available ... ultrasound. CT uses significant radiation and MRI a lower ... does not require injection of radioactive contrast material and ...
Cached Biology News:Lessening the dangers of radiation 2
(Date:7/31/2014)... Today BioSpace , the leading life sciences employment and ... the life sciences community in Illinois , ... , Michigan , Minnesota , ... and Wisconsin . BioMidwest is ... job postings on BioSpace originating in this region in 2013. The life ...
(Date:7/31/2014)... There,s a good reason people over 60 are not ... ages and weakens with time, making the elderly prone ... San Francisco research team now has discovered a reason ... for the inability of blood-forming cells to maintain blood ... identified molecular defects that could be restored for rejuvenation ...
(Date:7/31/2014)... and even the entire body to visualize long-range connections ... been a long-time dream of biologists. A study published ... journal Cell has now made that dream ... bodies, and human tissue biopsies transparent, while keeping the ... the way for a better understanding of brain-body interactions, ...
(Date:7/31/2014)... -- Chemists at Indiana University Bloomington have described ... fashion, a development with potential value for the ... transistors and photovoltaic cells. , Their paper, "Anion-Induced ... Solids and 2D Self-Assembled Crystals," has been published ... of the Royal Society of Chemistry. It is ...
Breaking Biology Technology:Midwest Biotech Leaders Featured On BioSpace Map 2Key to aging immune system is discovered 2See-through organs and bodies will accelerate biomedical discoveries 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3
... PITTSBURGH, Sept. 23 As the world converges on Pittsburgh ... are clear skies and the lack of the traditional, stereotypical ... they are greeted by a region that for the past ... to a service economy centered on the development and commercialization ...
... , , , ... the "Company") (OTC Bulletin Board: GLOB), an international healthcare information technology ... intent with verIDentia SL of Macanet De La Selva, Girona, ... were not disclosed. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20040226/GLOBALMEDLOGO ...
... Biological Sciences Research Council (BBSRC) have uncovered what happens ... found that the important proteins that make up the ... enzyme called cathepsin L. Scientists now have to take ... ensure the exciting field of nanomedicine can progress. The ...
Cached Biology Technology:Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 2Pittsburgh Life Sciences Greenhouse Demonstrates a Region's Economic Resilience 3Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 2Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 3Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 4Global Med Technologies(R) Signs Binding LOI With European Company for Breakthrough Transfusion Safety RFID Product 5New discovery reveals fate of nanoparticles in human cells 2
Anti-rat Dipeptidyl Peptidase IV (DPP IV), CD26, Clone 5E8, Monoclonal Antibody...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
... to detect the appearance of AcNPV gp64 ... as early as 8-24 hours post-infection. This ... Kit, which allows determination of baculovirus titers ... FastPlax Antibody can also be used to ...
synaptotagmin XIV-like [Source:RefSeq_peptide;Acc:NP_114120] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: