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Building a better mouse model of lung cancer: FHIT counts

inal cord, adrenal gland and other parts of the body.

The scientists exposed mice deficient in both genes to a second carcinogen, DMN, which is also found in smoke but also in beer, fish meal and some preserved meats. They discovered that when the VHL gene was missing as well, the mice were even more susceptible to tumor growth. "We thought this was interesting because this is the first indication that loss of just one of the two copies of the VHL gene could contribute to the development of cancer," says Huebner, noting that loss of one copy of the VHL gene occurs in several types of human lung cancer.

Huebner says there is still plenty of room for improvement in their new mouse model. There are several other genes on chromosome 3 that are also lost in many human lung cancers, and incorporating deficiencies in those genes with the current model will only make it stronger, she says, adding they're already working on it.

Other Ohio State researchers who contributed to the study include Nicola Zanesi, adjunct assistant professor and research scientist, George Calin, adjunct assistant professor, and Yuri Pekarsky, assistant professor, all in the department of molecular virology, immunology and medical genetics; Rita Mancini, post-doctoral researcher, and Mohamed Kaou, research associate, in the OSUCCC, and Carlo Croce, professor and chair of the department of molecular virology, immunology and medical genetics.


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Source:Ohio State University


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