Navigation Links
Building a better mouse model of lung cancer: FHIT counts

man experience of this disease."

Huebner and colleagues at Ohio State and Thomas Jefferson University bred two strains of mice, one that had only one copy of the FHIT gene, and another that lacked both copies. They also established a control group of normal mice that had both copies of the gene.

They exposed all the mice to NNK, a powerful carcinogen commonly found in tobacco smoke that researchers believe plays a major role in human lung cancer.

They discovered that while mice deficient in the FHIT gene's protein did not develop lung tumors any more frequently than did normal mice, the tumors they did develop were larger and more numerous. In addition, the severity of the tumor growth appeared to follow a continuum paralleling the loss of the protein. While the normal mice developed only benign tumors, 17 percent of the mice that had lost one copy of the gene developed malignant tumors and all of the tumors in the mice that lost both copies of the gene were malignant.

"This suggests that even very low levels of the protein might be enough to suppress or even prevent lung cancer," says Huebner.

Huebner had a hunch that pairing loss of protein with the loss of another tumor suppressor might enhance the research value of the new mouse model even more, so the research team bred another strain of mice that coupled the lack of the protein with partial loss of a second tumor suppressor gene, VHL, which also sits on chromosome 3 in humans. (Mice with loss of both copies of VHL do not survive.)

"We chose this gene because VHL is important in regulating angiogenesis, or the growth of blood vessels that tumors need to support themselves," says Huebner. "When VHL is in place and working properly, it blocks angiogenesis."

Interestingly, humans whose VHL gene is lost or mutated suffer from a condition called Von-Hippel Lindau disease, an inherited disorder characterized by abnormal blood vessel growth in the eyes, brain, sp
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Building a human kinase gene repository
3. Building a protein name dictionary from full text: a machine learning term extraction approach
4. Protein folding: Building a strong foundation
5. Chemists create Superbowl molecule; May lead to better health
6. Protein discovery could unlock the secret to better TB treatment
7. Signaling protein builds bigger, better bones in mice
8. Harnessing microbes, one by one, to build a better nanoworld
9. Two are better than one
10. Discovery may lead to better Candidiasis drug
11. Insects, viruses could hold key for better human teamwork in disasters
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Building better mouse model lung cancer FHIT counts

(Date:9/30/2014)... Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich report that ... cells more sensitive to chemotherapeutic drugs. They have ... a new target for anti-tumor agents. , ... Professor Stephan Sieber of the Technische Universitt Mnchen ... a potential new weapon in the fight against ...
(Date:9/30/2014)... 2014  Spectra Automation, a trusted supplier ... and power generation industries, announced today the ... an easy-to-use and cost-effective data collection, analysis ... laboratories. Most upstream process ... systems. Accessing and consolidating data from these ...
(Date:9/29/2014)... of gut bacteria called Clostridium ramosum , coupled with ... work is published this week in mBio , the ... , A research team from the German Institute of Human ... bacteria including C. ramosum gained weight when fed ... ramosum were less obese even when consuming a high-fat ...
Breaking Biology News(10 mins):Cancer therapy: Driving cancer cells to suicide 2Spectra Automation Introduces RECONN Bioprocess Manager 2Gut bacteria promote obesity in mice 2
... deposition associated with industry and agriculture can drive soils ... and polluting surface waters, according to a new study ... study, conducted in the Tatra Mountains of Slovakia by ... of Sciences, and the U.S. Geological Survey, shows what ...
... both physically and mentally, but genetically everyone is ... for decades now. But with population research becoming ... Tim Caulfield is concerned that genetic research could ... Nobel Prize winning geneticist James Watson claimed there ...
... new study by researchers at UC Davis Medical Center ... patients may be a result of their brains not ... drops in blood oxygen levels are more common than ... senior author Masud Seyal, a professor of neurology at ...
Cached Biology News:Acid soils in Slovakia tell somber tale 2Could genetic research awaken racist attitudes? 2Drops in blood oxygen levels may be key to sudden death in some epilepsy patients 2Drops in blood oxygen levels may be key to sudden death in some epilepsy patients 3
(Date:10/1/2014)... 30, 2014 This report analyzes ... US$ Million by the following Product Segments: ... Specific end-use segments also analyzed are Pharmaceuticals ... The report provides separate comprehensive analytics for ... East, and Latin America. Annual estimates and ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
(Date:9/30/2014)... Shimadzu Scientific Instruments has released ... highly precise tool for measuring displacement in rubber ... 1000-mm maximum movement distance, the DSES-1000 can measure ... length of 10 mm. In addition, it achieves ... stroke and within +/- 100 µm below 50-mm ...
(Date:9/30/2014)... Jose, California (PRWEB) September 30, 2014 ... measure the level of each type of cholesterol carrier ... since the presence of excessive cholesterol levels in the ... a precursor condition to heart attack and other cardiovascular ... fatality worldwide, therefore testing for cholesterol levels on a ...
Breaking Biology Technology:Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... Lund University in Sweden have discovered a new stem cell ... several different cell types -- most importantly, they can form ... finding to develop methods to heal and repair disease and ... biopsies, the researchers for the first time found stem cells ...
... April 19, 2012  Phigenics LLC, an innovative water management ... paper that demonstrates up to 33% false-positive test results ... methods. A false-positive result means the test indicated ... detectable levels when in fact it was below detectable ...
... Biofuels, LLC, a joint venture between BP and ... collaboration with Fagen, Inc. for the introduction of ... the world,s most experienced biofuels engineering, procurement and ... any other company.  They are the largest, most ...
Cached Biology Technology:New Stem Cell Found in the Brain 2New Stem Cell Found in the Brain 3Phigenics Research Challenges Accuracy Of Conventional Legionella Testing Protocol 2Phigenics Research Challenges Accuracy Of Conventional Legionella Testing Protocol 3Butamax™ and Fagen Announce Collaboration to Retrofit Ethanol Plants for Biobutanol Production 2
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... sample is a complex protein sample, ... when used with ReadyPrep 2-D starter ... sample can be used as a ... and protocol before using more difficult ...
... materials for 1,464 array sample elements. , ,Includes: ... , Blocker BSA in PBS (10X): 50 ml ... g , BupH Phosphate Buffered Saline: ... 2 x 10 ml ampules , SuperSignal West Pico ...
... Mouse polyclonal antibody raised ... Immunogen: ... 112 a.a) partial recombinant protein ... Accession Number: NM_130777 ...
Biology Products: