Navigation Links
Building a better mouse model of lung cancer: FHIT counts

Scientists have identified some of the very earliest genetic changes involved in the development of lung cancer and have incorporated them into a new strain of mouse that develops the disease in much the same way that humans do.

The discoveries, reported in the August 1 issue of Cancer Research, open the door to the possibility of new, targeted treatments that could be offered at the very first signs of lung cancer, when the possibility of a cure is most likely.

Creating the new mouse was basically a matter of FHIT ?the gene that forms the cornerstone of the new model ?according to Kay Huebner, a professor of molecular virology, immunology and medical genetics and a researcher in Ohio State University 's Comprehensive Cancer Center (OSUCCC). Huebner, the senior author of the study, has studied FHIT for years, noting it is one of several tumor suppressor genes residing on chromosome 3 in humans that, when working normally, keep any potentially cancerous cells from growing out of control.

But when mutations or alterations eliminate one or both copies of the FHIT gene, the "brakes" that control cell growth are released, allowing potentially cancerous lesions to become malignant.

Studies show that very early in the development of lung cancer, the FHIT gene loses its ability to produce a specific protein (called Fhit). This same loss has been linked to head and neck, esophageal, colorectal, breast and cervical cancers as well.

Because the loss of FHIT occurs so early in lung cancer, mice that are missing that gene may be a good model in which to test new ways to treat or prevent the disease, says Huebner. "There are some other useful mouse models out there, but they generally reflect genetic mutations that happen later in the disease, when tumors are clearly visible and successful treatment unlikely," says Huebner. "We were interested in creating a model that reflected the timing and order of genetic and epigenetic changes in the hu
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Whats really making you sick? Plant pathologists offer the science behind Sick Building Syndrome
2. Building a human kinase gene repository
3. Building a protein name dictionary from full text: a machine learning term extraction approach
4. Protein folding: Building a strong foundation
5. Chemists create Superbowl molecule; May lead to better health
6. Protein discovery could unlock the secret to better TB treatment
7. Signaling protein builds bigger, better bones in mice
8. Harnessing microbes, one by one, to build a better nanoworld
9. Two are better than one
10. Discovery may lead to better Candidiasis drug
11. Insects, viruses could hold key for better human teamwork in disasters
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Building better mouse model lung cancer FHIT counts

(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - ... partnership centralized around the incorporation of handyem,s HPC-150 ... diagnostic laboratory, the Mo-POD™. This unprecedented model of ... International Conference at the Pennsylvania ... from June 15 th to 18 th ...
(Date:6/16/2015)... Fingerprint Cards (FPC) raises the revenue guidance for ... at least 340 MSEK to that it will amount to ... growth and orders received the revenue guidance for 2015 is ... will exceed 1,500 MSEK to an updated guidance that revenue ... Due to receipt of orders of touch fingerprint sensors with ...
(Date:6/15/2015)... --NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market, announces that its leading payment security technology, the Wocket® ... @ NYC June 18th. Digital Experience! @ NYC ... technology to over 300 of the top media covering the ... in New York City from 6:00 ...
Breaking Biology News(10 mins):handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 2Wocket Smart Wallet Exhibiting at Pepcom Digital Experience! @ NYC June 18th 3
... of agriculture may have come with the domestication of ... ago, roughly a thousand years before such staples as ... The discovery dates domesticated figs to a period some ... trees the oldest known domesticated crop. , Ofer Bar-Yosef ...
... which survive in extreme cold, scientists no longer have ... and glaciers. Bacteria previously isolated from polar climates, and ... cold, have been isolated from soil in temperate environments. ... University, Canada, have developed a technique to isolate bacteria ...
... - thought to act as an oxygen store in the ... also exists in many other tissues of the common carp, ... , Myglobin is found in large quantities in diving mammals ... for long periods during deep sea dives. Similarly in humans, ...
Cached Biology News:Tamed 11,400 years ago, figs were likely first domesticated crop 2Common carp sheds new light on surviving in extreme environments 2
(Date:6/29/2015)... 29, 2015   Veracyte, Inc . (Nasdaq: ... of molecular cytology, today announced that it has been ... Workplaces list for the second year in a row. ... on an annual survey of Bay Area-company employees. ... degree to which Veracyte values our employees and their ...
(Date:6/26/2015)... 26, 2015  SeraCare Life Sciences, a leading ... announced that it has signed a Cooperative Research ... Institute (NCI), part of the National Institutes of ... for cancer assays.  The CRADA will investigate the ... control DNA biosynthetics spiked into a genomic DNA ...
(Date:6/26/2015)... ... June 26, 2015 , ... Charm Sciences, ... Inspection, Packers and Stockyards Administration (GIPSA) awarded a five year contract to Charm ... grains utilizing Charm’s ROSA DONQ-FAST5 Test. This 5 minute quantitative test extracts DON ...
(Date:6/26/2015)... Upland, California (PRWEB) , ... June 26, 2015 ... ... preparation devices, today announced that its SimplePrep™ technologies have been integrated into a ... the International Space Station (ISS) as a part of the NASA’s WetLab-2 Project. ...
Breaking Biology Technology:Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 2Veracyte Named a 2015 "Top Workplace" in the San Francisco Bay Area 3SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 2SeraCare Life Sciences Signs CRADA with NCI to Advance Cancer Diagnostics 3USDA-GIPSA (FGIS) Awards 5 Year Contract for Vomitoxin Tests to Charm Sciences 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3
... www.tedmed.com , the world,s leading multi-disciplinary conference on the future ... of the conference will take place in Washington, DC at ... April 11-13, 2012. From 2009 to 2011, San ... and technology developers. The move to the Nation,s Capital and ...
... -- Andrew Barron, Rice University,s Charles W. Duncan, Jr. ... science, is the winner of the prestigious 2011 World ... the World Technology Summit and Awards gala at the ... the application of nanotechnology to fundamental problems in energy ...
... VetNostic Laboratories® offers state-of-the-art genetic testing services for ... are able to accurately and specifically determine whether ... reliable identification of these "carriers" ensures healthy litters ... VetNostic Laboratories® is pleased to introduce two new ...
Cached Biology Technology:TEDMED Announces Move to Washington, DC; the John F. Kennedy Center for Performing Arts Will Host TEDMED 2012 Conference 2TEDMED Announces Move to Washington, DC; the John F. Kennedy Center for Performing Arts Will Host TEDMED 2012 Conference 3TEDMED Announces Move to Washington, DC; the John F. Kennedy Center for Performing Arts Will Host TEDMED 2012 Conference 4TEDMED Announces Move to Washington, DC; the John F. Kennedy Center for Performing Arts Will Host TEDMED 2012 Conference 5Rice's Barron wins World Technology Award for Materials 2VetNostic Laboratories® Announces New Testing for Dog Breeds 2VetNostic Laboratories® Announces New Testing for Dog Breeds 3
... containing an overproducing clone of M-MLV Reverse ... the polymerization of DNA using template DNA, ... large mRNAs, >10 kb, may be synthesized. ... RNase H activity than AMV Reverse Transcriptase ...
... catalyzes the template-directed polymerization of nucleotides into ... Polymerase I possesses a 3?5 exonuclease activity ... rate during DNA replication, and also contains ... enzyme to replace nucleotides in the growing ...
Request Info...
... yeast/leuconostoc overproducer ATP: D-hexose 6- ... One unit of HK will ... in 1 min at 25C ... of G6P-DH will oxidize 1 ...
Biology Products: