Navigation Links
Buckyballs used as 'passkey' into cancer cells

Scientists at Rice University and pediatric specialists at Baylor College of Medicine have discovered a new way to use Rice's famed buckyball nanoparticles as passkeys that allows drugs to enter cancer cells.

The research appears in the Jan. 21 issue of the journal Organic and Biomolecular Chemistry.

All living cells defend themselves by walling off the outside world. Cell walls, or membranes, form a protective cocoon around the cell's inner machinery and its DNA blueprints.

"Drugs are far more effective if they're delivered through the membrane, directly into the cell," said lead researcher Andrew Barron. "Viruses, which are often toxic, long ago developed ways of sneaking through cell walls. While we're mimicking some techniques used by viruses, we're using non-toxic pieces of protein, and we're incorporating buckyballs as a passkey."

The passkeys that Barron and colleagues developed contain a molecule called Bucky amino acid that was created in Barron's lab. Bucky amino acid, or Baa, is based on pheylalanine, one of the 20 essential amino acids that are strung together like beads on a necklace to build all proteins.

Barron's graduate student, Jianzhong Yang, developed several different Baa-containing peptides, or slivers of protein containing about a dozen or so amino acids. In their natural form, with pheylalanine as a link in their chain, these peptides did not pass through the cell walls.

Barron's group collaborated with Yang's brother, Baylor College of Medicine assistant professor Jianhua Yang at Texas Children's Cancer Center, and found the Baa-containing peptides could mimick viral proteins and pass through the walls of cancer cells. The peptides were found effective at penetrating the defenses of both liver cancer cells and neuroblastoma cells.

"Neuroblastoma is the most common extracranial solid tumor in children, and it is responsible for about 15 percent of pediatric cancer deaths," sai
'"/>

Source:Rice University


Page: 1 2

Related biology news :

1. Buckyballs boost antibodys chemotherapy payload
2. Viral DNA sequence a possible trigger for breast cancer
3. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
4. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
5. Columbia research lifts major hurdle to gene therapy for cancer
6. Combination therapy boosts effectiveness of telomere-directed cancer cell death
7. Mitochondrial DNA mutations play significant role in prostate cancer
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. BRCA1 causes ovarian cancer through indirect, biochemical route
10. Researchers identify target for cancer drugs
11. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Buckyballs used passkey into cancer cells

(Date:4/17/2014)... In the most densely forested and most densely populated ... of human needs, values and practices. Disturbances associated with ... agriculture and development, have set the stage for management ... study reports. , The report Five anthropogenic factors ... in the Northern United States was published ...
(Date:4/17/2014)... 2014The development of stem cell therapies to cure a ... stem cell populations based on cell surface markers. Researchers ... marker that is highly expressed in a type of ... they describe in an article in BioResearch Open ... Inc., publishers. The article is available free on the ...
(Date:4/17/2014)... detection cartridge developed at Sandia National Laboratories and recently ... faster and cheaper. , Bacillus anthracis , ... soils all over the world and can cause serious, ... The bacteria can survive in harsh conditions for decades. ... occur through skin contact, inhalation of spores or eating ...
Breaking Biology News(10 mins):Five anthropogenic factors that will radically alter northern forests in 50 years 2Five anthropogenic factors that will radically alter northern forests in 50 years 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... Wasps, bees, ants and relatives comprise the megadiverse ... speciose animal group on Earth, far surpassing the ... most diverse orders of animals (beetles, butterflies, wasps, ... insects with complete metamorphosis, i.e. having a dormant ...
... Elsevier, EuroStemCell, and Kyoto University,s Institute for Integrated ... Trends and Perspectives on the Evolving International Landscape" at ... of the growth and development of the stem cell ... for embryonic stem (ES) cell, human embryonic stem (hES) ...
... a scientist exposes rats to a certain pesticide over ... similar to those seen in Parkinson,s patients. But the ... affects 7 million to 10 million people worldwide, is ... Engineering News , the weekly newsmagazine of the American ...
Cached Biology News:Fossils clarify the origins of wasps and their kin: alderfly ancestors, snakefly cousins 2New report on stem cell research reveals the field is growing twice as fast as the world average 2New report on stem cell research reveals the field is growing twice as fast as the world average 3
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014  RXi ... on discovering, developing and commercializing innovative therapies addressing ... announced that it received the Notice of Allowance ... on its unique self-delivering RNAi compounds (sd-rxRNA®), for ...
(Date:1/14/2014)... OTTAWA, Ontario , Jan. 14, 2014   Kinaxis ®, ... ( SCM ) and sales and operations planning ( S&OP ... the Biomanufacturing Summit , which will be held at ...  At the conference, join Kinaxis customer Elisabeth Kaszas , ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, ... dual arch impressions on its dental blog. , ... entry serves up a list of tips to help dentists ... Dr. David Little as he crafts a porcelain crown using ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Independent publisher ... California, and Montreal, Canada, has big ideas for 2014 ... The press's goals are to produce high-quality, low-cost, DRM-free ... support local businesses. , The first major development ...
Breaking Biology Technology:RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... -- China,Biologic Products, Inc. (OTC Bulletin Board: CBPO) ("CBP," ... in the People,s,Republic of China ("PRC"), today announced that ... on Tuesday, May 19, 2009, to discuss the 2009 ... the call will be Mr. Colin Zhao, Chief Executive ...
... the 92 naturally occurring elements, add another to the list ... professor of physics in Arts & Sciences at Washington University ... student at the time discovered that europium becomes superconducting ... of pressure, making it the 53rd known elemental superconductor and ...
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), ... for heart failure patients, received notification from the U.S. ... released the Company,s CD-NP development program from clinical hold.As ... FDA the finalized protocol for the Company,s planned 30-patient ...
Cached Biology Technology:China Biologic Products Announces 2009 First Quarter Results Conference Call 2Europium discovery 2Europium discovery 3Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA 2Nile Therapeutics CD-NP Clinical Program for Acute Heart Failure Released From Clinical Hold by FDA 3
...
... All MagCellect Ferrofluid products ... conjunction with R&D Systems MagCellect ... capacities, this neodymium iron boron ... 12 x 75 mm test ...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Agarase cleaves agarose to neoagaro-oligosaccharides, and is used for,quantitative, gentle recovery of DNA from low melting point agarose....
Biology Products: