Navigation Links
Bubbles go high-tech to fight tumors

Bubbles: You've bathed in them, popped them, endured bad song lyrics about them. Now, University of Michigan researchers hope to add a more sophisticated application to the list---gas bubbles used like corks to block oxygen flow to tumors, or to deliver drugs.

The process of blocking blood flow to a tumor is called embolization, and using gas bubbles is a new technique in embolotherapy. What makes it so promising is that the technique allows doctors to control exactly where the bubbles are formed, so blockage of blood flow to surrounding tissue is minimal, said Joseph Bull, assistant professor of biomedical engineering at U-M.

The research of Bull and collaborator Brian Fowlkes, an associate professor in the Department of Radiology in the U-M Medical School, is currently focused on the fundamental vaporization and transport topics that must first be understood in order to translate this developmental technique to the clinic.

In traditional embolotherapy techniques, the so-called cork that doctors use to block the blood flow---called an emboli---is solid. For instance, it could be a blood clot or a gel of some kind. A major difficulty with these approaches is restricting the emboli to the tumor to minimize destruction of surrounding tissue, without extremely invasive procedures, Bull said. The emboli must be delivered by a catheter placed into the body at the tumor site.

Gas bubbles, on the other hand, allow very precise delivery because their formation can be controlled and directed from the outside, by a focused high intensity ultrasound.

This envisioned technique is actually a two-step process, Bull said. First, a stream of encapsulated superheated perfluorocarbon liquid droplets goes into the body by way of an intravenous injection. The droplets are small enough that they don't lodge in vessels. Doctors image the droplets with standard ultrasound, and once the droplets reach their destination, scientists hit them with high intensity ultrasound. The ultrasound acts like a pin popping a water balloon. After the shell pops, the perfluorocarbon expands into a gas bubble that is approximately 125 times larger in volume than the droplet.

"If a bubble remained spherical its diameter would be much larger than that of the vessel," Bull said. "So it deforms into a long sausage-shaped bubble that lodges in the vessel like a cork. Two or three doses of bubbles will occlude most of the (blood) flow." Without blood flow, the tumor dies.

Because the bubble is so big, it's critical to get the right vessel in order not to damage it.

"How flexible the vessel is plays a very important role in where you do this," Bull said. That is the subject of a paper coming out on gas embolotherapy in the August issue of the Journal of Biomechanical Engineering.


'"/>

Source:University of Michigan


Related biology news :

1. Learning to fight an adversary that wont stay down
2. Antibiotic might fight HIV-induced neurological problems
3. NYU study reveals how brains immune system fights viral encephalitis
4. Molecular models advance the fight against malaria
5. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
6. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
7. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
8. Two chemicals boost immune cells ability to fight HIV without gene therapy
9. Experiment station researchers to explore genome of disease-fighting fungus
10. Bacterial genome sheds light on synthesizing cancer-fighting compounds
11. Tadpole soon to help in the fight against cancer and lymphedema
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... ivWatch LLC , a medical device company focused on improving the ... its ISO 13485 Certification, the global standard for medical device quality ... ... device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates ...
(Date:6/23/2017)... N.Y. and ITHACA, N.Y. ... ) and Cornell University, a leader in dairy research, ... with bioinformatics designed to help reduce the chances that ... With the onset of this dairy project, Cornell University ... Consortium for Sequencing the Food Supply Chain, a food ...
(Date:5/16/2017)...  Veratad Technologies, LLC ( www.veratad.com ), an innovative ... verification solutions, announced today they will participate as a ... thru May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions ... evolving digital world, defining identity is critical to nearly ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
(Date:10/11/2017)... the Netherlands and LAGUNA HILLS, Calif. ... The Institute of Cancer Research, London ... use MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients ... trial known as MUK nine . The University of ... trial, which is partly funded by Myeloma UK, and ICR ...
(Date:10/11/2017)... ... 11, 2017 , ... Singh Biotechnology today announced that the ... its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) B VHH13 single ... the cell membrane and bind intracellular STAT3 and inhibit its function. Dysregulation of ...
(Date:10/10/2017)... ... October 10, 2017 , ... For ... has won a US2020 STEM Mentoring Award. Representatives of the FirstHand program travelled ... Volunteer Experience from US2020. , US2020’s mission is to change the trajectory of ...
Breaking Biology Technology: