Navigation Links
Brown team finds crucial protein role in deadly prion spread

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions ?strange, self-replicating proteins that cause fatal brain diseases ?convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process ?fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "crusher," Serio thought.

To test th ese ideas, Serio and members of her lab studied Sup35, a yeast protein similar to the human prion protein PrP. They put Sup35 together with Hsp104, then activated and deactivated Hsp104. They found that the protein does, indeed, chop up Sup35 complexes ?the first direct evidence that this process occurs in a living cell and that Hsp104 is the culprit.

"To understand how fragmentation speeds the spread of prions, think of a dandelion," Serio said. "A dandelion head is a cluster of flowers that each carries a seed. When the flower dries up and the wind blows, the seeds disperse. Prion protein works the same way. Hsp104 acts like the wind, blowing apart the flower and spreading the seeds."

Serio said that prions still multiply without fragmentation. However, she said, they do so at a much slower rate. So a drug that blocked the activity of Hsp104 could seriously slow progression of prion-related diseases.


'"/>

Source:Brown University


Related biology news :

1. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
2. Prions rapidly remodel good protein into bad, Brown study shows
3. Brown seaweed contains promising fat fighter, weight reducer
4. Brown scientists map structure of DNA-doctoring protein complex
5. Brown cancer biologists identify major player in cell growth
6. Bones in motion: Brown scientists to create new 3-D X-ray system
7. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
8. Study finds more than one-third of human genome regulated by RNA
9. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
10. Same mutation aided evolution in many fish species, Stanford study finds
11. NC State scientist finds soft tissue in T. rex bones
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... Minn. , Jan. 20, 2016   MedNet ... supports the entire spectrum of clinical research, is pleased ... 2015. MedNet,s significant achievements are the result of the ... iMedNet eClinical , it,s comprehensive, easy-to-use ... --> --> Key MedNet growth achievements ...
(Date:1/15/2016)... SAN JUAN, Puerto Rico , Jan. 15, 2016 ... forcing companies big and small to find new ways ... data driven culture. iOS and ... their device based on biometrics, transforming it into a ... can request that users swipe their fingerprint on their ...
(Date:1/11/2016)... Calif. , Jan. 11, 2016 Synaptics ... human interface solutions, today announced that its ClearPad ® ... integration (TDDI) products won two separate categories in the ... Mobile Innovator and Best Technology Breakthrough. The Synaptics ® ... cost, a simplified supply chain, thinner devices, brighter displays ...
Breaking Biology News(10 mins):
(Date:2/8/2016)... ... , ... Information Management Services ( IMS ) is pleased to announce a ... technical foundation and is so significant it was endowed with a new name, BSI ... search results, a streamlined layout and a more intuitive format for navigating the system. ...
(Date:2/8/2016)... (NYSE MKT: NNVC) (the "Company"), a nanomedicine company developing anti-viral drugs, ... present information about the company,s programs at the BIOCEO conference today ... City . --> --> ... Registered attendees can request a one on one meeting through the conference ... --> New York City . --> ...
(Date:2/8/2016)... February 8, 2016 ... or the "Company"), the ultra-rapid Point-Of-Care (POC) molecular diagnostics company, ... its Chlamydia trachomatis (CT) test to be launched on the ... Directive (98/79/EC), the CT test is now cleared for sale ... --> The launch of the io® CT test signals ...
(Date:2/5/2016)... Va. , Feb. 5, 2016 ATCC, ... is poised to assist the medical and life science ... around Zika Virus infection.   CDC website ... --> Zika virus is a single-stranded RNA ... includes the West Nile, Dengue and Chikungunya Viruses. Zika ...
Breaking Biology Technology: