Navigation Links
Brown team finds crucial protein role in deadly prion spread

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions ?strange, self-replicating proteins that cause fatal brain diseases ?convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process ?fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "crusher," Serio thought.

To test th
'"/>

Source:Brown University


Page: 1 2

Related biology news :

1. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
2. Prions rapidly remodel good protein into bad, Brown study shows
3. Brown seaweed contains promising fat fighter, weight reducer
4. Brown scientists map structure of DNA-doctoring protein complex
5. Brown cancer biologists identify major player in cell growth
6. Bones in motion: Brown scientists to create new 3-D X-ray system
7. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
8. Study finds more than one-third of human genome regulated by RNA
9. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
10. Same mutation aided evolution in many fish species, Stanford study finds
11. NC State scientist finds soft tissue in T. rex bones
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown team finds crucial protein role deadly prion spread

(Date:7/30/2014)... research from Bjorn Brembs, professor of neurogenetics at the ... proof-of-concept figure allowing readers and reviewers to run the ... an important leap forward for scientific publishing, by demonstrating ... a scholarly output. , Figure 3 in fact doesn,t ... code to F1000Research , and the figure is ...
(Date:7/30/2014)... of major interest in neuroscience. A large number ... stages of Wallerian degeneration: transcription factor activation, immune ... expression responses in the distal segment of the ... differences in gene expression between the proximal and ... co-workers from Nantong University, China used microarrays to ...
(Date:7/30/2014)... cells types. Researchers would like to understand how to channel ... make up the organs and other structures of living organisms. ... sugars that dangle from proteins on surfaces of cells. , ... has created synthetic molecules that can stand in for the ... the process, they report in the Journal of the ...
Breaking Biology News(10 mins):F1000Research brings static research figures to life 2
... research on aging and the life histories of diverse ... for individuals and tends to decrease lifespan rather than ... and Hynek Burda from the University of Duisburg-Essen shows ... true as well. , The authors, studying captive Zambian ...
... University of Florida scientists have found that people have ... personified today by a jawless, eel-like fish. , It ... different evolutionary road than almost all other backboned animals, ... terms of the genetics that govern their skeletal development, ...
... "evolutionary conversion" provides a modern-day snapshot of how life ... of the earliest primordial mix of RNA-like molecules-sometimes referred ... of RNA-based life (or the "RNA world") and eventually ... acids are large complex molecules that store and convey ...
Cached Biology News:UF scientists reveal ancient origin of vertebrate skeleton 2UF scientists reveal ancient origin of vertebrate skeleton 3'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro 2'Accelerated evolution' converts RNA enzyme to DNA enzyme in vitro 3
(Date:7/30/2014)... CHICAGO , July 30, 2014  The Chicago ... the American Academy of Dermatology (Academy) in an effort ... the Chicago Bears will host free SPOT me™ skin ... August 2 at Soldier Field. SPOT me™ is ... men, about the dangers and risks of skin cancer, ...
(Date:7/30/2014)... Geneva, Switzerland (PRWEB) July 30, 2014 ... proven technologies for biologic drug discovery and mammalian cell ... SURE CHO-Mplus Libraries ™ will be presented at ... conference being held, September 8 – 10, 2014 ... Berkeley, California. , The following abstract will be ...
(Date:7/30/2014)... Albany, NewYork (PRWEB) July 30, 2014 ... population, the increase of personal health expenditure as ... government health care system, China diagnostic reagent industry ... reagents occupy over 90%. In 2013, Chinese in ... which RMB16.61 billion came from in vitro diagnostic ...
(Date:7/30/2014)... Vycom announces the addition of Thermax ... meet Factory Mutual (FM) 4910 fire propagation and smoke ... benches, process tools, fume hoods, furniture and cabinetry. These ... semiconductor wafers used in electronic chip manufacturing. , ... with excellent workability and superior aesthetics. It is available ...
Breaking Biology Technology:Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 2Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 3Chicago Bears Join the American Academy of Dermatology in Fight against Skin Cancer 4Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 2Selexis SA to Present New Data and a Case Study at IBC’s Cell Line Development and Engineering Conference 3China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2
... SAN DIEGO, Sept. 22 SoluLinK, Inc., a leader ... Catalyst, making conjugation at least 20 times faster than before ... , , Up to now, researchers, conjugation ... poor yields, poor quality and more labor and time consuming ...
... California and AMSTERDAM, September 22 ,Agendia, a world leader ... a US $23 million series E investment. The financing,round ... provided,approximately half of the funds. In addition, two independent ... while the remaining,capital was raised through Agendia,s existing investor ...
... , , CHICAGO, Sept. 22 ... healthcare. The average rate of compliance is only 50%. Noncompliance is ... annual cost of $100B. , , A recent ... by Leap of Faith Technologies, demonstrated a positive effect on compliance ...
Cached Biology Technology:SoluLinK Introduces Product that Links All Biomolecules Greater Than 20 Times Faster with 100% Yields 2Agendia Raises US $23 Million in Series E Financing 2Medication Telemonitoring Improves Compliance and Behavior in NIH Study 2
dynactin 4, mRNA (cDNA clone MGC:3248 IMAGE:3505855), complete cds...
Edited by D. Rickwood, T.C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolec...
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure Grade DAPI is greater than or equal to 98% pure by HPLC....
Biology Products: