Navigation Links
Brown team finds crucial protein role in deadly prion spread

A single protein plays a major role in deadly prion diseases by smashing up clusters of these infectious proteins, creating the "seeds" that allow fatal brain illnesses to quickly spread, new Brown University research shows.

The findings are exciting, researchers say, because they might reveal a way to control the spread of prions through drug intervention. If a drug could be made that inhibits this fragmentation process, it could substantially slow the spread of prions, which cause mad cow disease and scrapie in animals and, in rare cases, Creutzfeldt-Jacob disease and kuru in humans.

Because similar protein replication occurs in Alzheimer's and Parkinson's diseases, such a drug could also slow progression of these diseases as well.

"The protein fragmentation we studied has a big impact on how fast prion diseases spread and may also play a role in the accumulation of toxic proteins in neurodegenerative diseases like Parkinson's," said Tricia Serio, an assistant professor in Brown's Department of Molecular Biology, Cell Biology and Biochemistry and lead researcher on the project.

The findings from Serio and her team, which appear online in PLoS Biology, build on their groundbreaking work published in Nature in 2005. That research showed that prions ?strange, self-replicating proteins that cause fatal brain diseases ?convert healthy protein into abnormal protein through an ultrafast process.

This good-gone-bad conversion is one way that prions multiply and spread disease. But scientists believe that there is another crucial step in this propagation process ?fragmentation of existing prion complexes. Once converted, the thinking goes, clusters of "bad" or infectious protein are smashed into smaller bits, a process that creates "seeds" so that prions multiply more quickly in the body. Hsp104, a molecule known to be required for prion replication, could function as this protein "crusher," Serio thought.

To test th
'"/>

Source:Brown University


Page: 1 2

Related biology news :

1. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
2. Prions rapidly remodel good protein into bad, Brown study shows
3. Brown seaweed contains promising fat fighter, weight reducer
4. Brown scientists map structure of DNA-doctoring protein complex
5. Brown cancer biologists identify major player in cell growth
6. Bones in motion: Brown scientists to create new 3-D X-ray system
7. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
8. Study finds more than one-third of human genome regulated by RNA
9. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
10. Same mutation aided evolution in many fish species, Stanford study finds
11. NC State scientist finds soft tissue in T. rex bones
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown team finds crucial protein role deadly prion spread

(Date:7/24/2014)... at The University of Texas Health Science Center at ... to help Harris County residents whose vision problems cannot ... with corrective lenses, many people with low vision can ... of low vision devices, such as telescopes, magnifiers and ... Iyer is using the three-year, $164,645 SightFirst grant from ...
(Date:7/24/2014)... For years, researchers and patients have hoped that embryonic ... in the bodycould provide insight into numerous diseases perhaps ... been hampered by the inability to transfer research and ... in part because human ESCs are "primed" and slightly ... Theunissen, Benjamin Powell, and Haoyi Wang, who are scientists ...
(Date:7/24/2014)... fires covered central Africa in mid-July 2014, as the ... hotspots, which indicate areas of increased temperatures, are heavily ... Republic of the Congo (northeast), and Zambia (southeast). Thick ... in some areas, especially in the Democratic Republic of ... south. , The fire season is an annual event ...
Breaking Biology News(10 mins):UTHealth Dr. Bhavani Iyer awarded low vision grant 2Whitehead Institute researchers create 'naïve' pluripotent human embryonic stem cells 2
... regulates critical cellular activities in plants and animals by ... Looking to learn from nature, a team of Northwestern ... the Air Force Office of Scientific Research to study ... and civilian applications. The grant is part of ...
... Outbreaks of the notorious crown of thorns starfish now threaten ... on Earth, according to recent surveys by the Bronx Zoo-based ... Reef Studies. The starfish a predator that feeds ... digestive enzymes to liquefy tissue were discovered in large ...
... scientific books and journals, was acquired by Springer ... available on www.springerlink.com along with more ... 22,000 eBooks. Beginning with the subscription year 2008, ... journals through Springer. All issues previously available on ...
Cached Biology News:Team of chemists receives $5 million grant to develop enzyme mimics 2Starfish outbreak threatens corals 2Humana Press journals now available on SpringerLink 2
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, announced today ... a presentation to investors on Tuesday, July 29, ...  The presentation will include an overview of Asterias, ... the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least ...
(Date:7/24/2014)... forces worldwide rely on sophisticated equipment, trained personnel, ... public areas against terrorist attacks. A revolutionary new ... to make their job much easier. , The ... of Tel Aviv University ,s School of Chemistry ... by the Herzliya company Tracense, picks up the ...
(Date:7/24/2014)... to materialise. Yet, scientists are making progress in ... One such approach relies on quantum dotsa kind ... electric field. A new study demonstrates that changing ... (TQDs) with electrical impulses can help better control ... be used as quantum information units, which would ...
(Date:7/24/2014)... and synthetic processes prefer to settle into equilibriuma ... is within the realm of non-equilibrium conditions where ... in energy and phases, such as temperature fluctuations, ... humans to regulate their body temperature, airplanes to ... activity. , But even though these conditions ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2
... 13 Millennium,Pharmaceuticals, Inc. (Nasdaq: MLNM ) ... Global Pharmaceutical, Biotech and Medtech Conference,will be webcast ... Investors section,of the Company,s website, http://www.millennium.com . ... presentation will include an overview of the Company, ...
... Cephalon, Inc. (Nasdaq:,CEPH) today communicated with ... dosing and administration for FENTORA(R),(fentanyl buccal tablet) ... the medical community to reinforce the appropriate ... letter, issued in collaboration with the U.S. ...
... Technology Symposium Brings Together Thought Leaders,in Life Sciences ... Practices, OOSTERHOUT, Netherlands, Sept. 13 Luminex,Corporation ... multiplexed solutions,today announced the agenda for Planet xMAP ... The two-day event will be,held 2-3 October at ...
Cached Biology Technology:Merrill Lynch Global Pharmaceutical, Biotech and Medtech Conference to Webcast Millennium Presentation 2Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA 2Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA 3Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA 4Cephalon Reinforces Important Prescribing and Dosing Information for FENTORA 5Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 2Luminex Corporation Hosts the Fifth Annual Planet xMAP Europe 2007 Symposium 3
... Guava PCA-96 systems provide automated, higher throughput ... of microcentrifuge tubes. This flexible sample format ... screening in basic research, target validation, assay ... smaller cousin, the Guava PCA-96 uses a ...
... antibody irreversibly crosslinked to protein G-agarose beads ... complex from heart mitochondria. Also included are ... control immunocapture. ,The pyruvate dehydrogenase complex (PDH) ... small amounts of tissue. This facilitates the ...
... of a protein into cells permits studies ... pathways, apoptotic pathways, and transcription factor-mediated gene ... the effects of a specific protein in ... protein directly into the cell. ProteoJuice Protein ...
... BD FACSVantageTM SE flow cytometry system is ... laboratory. For over 25 years, BD cell ... are found in leading university, pharmaceutical, and ... To meet the research demands of today, ...
Biology Products: