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Brown scientists map structure of DNA-doctoring protein complex

lexible to analyze through standard methods such as X-ray crystallography.

Sun used fluorescence resonance energy transfer or FRET, a technique typically used to study small protein complexes in a solution. This time, Sun used FRET to study large protein complexes in a gel. He tagged the DNA with fluorescent dyes and purified the proteins, placing them in a gel that was then shot through with light. Sun measured the wavelengths of light as they bounced between the molecules of dye. Those measurements were then fed into a special software program created by Dale Mierke, a Brown professor of medical science, which plotted their positions to create the structural map.

"The real breakthrough here is successfully using FRET to determine the structure of a large protein-DNA complex," Sun said. "Biologists now have a new tool to help them understand a variety of these complexes, including ones that control cell division, gene expression and DNA replication. So this technique represents a big advance."
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Source:Brown University


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