Navigation Links
Brown cancer biologists identify major player in cell growth

When cells go about the business of dividing, they can get sidelined. Maybe there aren't enough nutrients. Maybe there aren't the right signals to resume multiplying. Either way, cells go quiet.

What can restart cell division -- the process that drives the development of embryos, the renewal of hair, skin and blood, and the creation of cancer -- is a single transcription factor called GABP, according to new research from The Warren Alpert Medical School of Brown University and Rhode Island Hospital.

The work, published online in Nature Cell Biology, introduces a new pathway that can be manipulated to control cell growth. Since cell growth is a fundamental biological process, the research may shed light on everything from miscarriages to muscular dystrophy. The main application, however, is cancer. Since a key characteristic of cancer cells is unchecked growth, the research identifies potential targets for new treatments.

"As a scientist and a physician, I am tremendously excited," said Alan Rosmarin, M.D., an associate professor in the Department of Medicine and the Department of Molecular Biology, Cell Biology and Biochemistry at Brown and director of clinical oncology research for Lifespan, Rhode Island's largest health care system. "This discovery not only adds to our basic understanding of cell division, it could lead to better cancer drugs. And they're needed. Cancer touches everyone."

During the cell cycle, the four-phase process of cell division, there is a period when the biochemical brakes are put on and cells become inactive. Then the process is kick-started and cells move into the so-called S phase, when DNA is duplicated. This is a critical juncture. If genes are missing or broken, these alterations are passed on to the new cell -- and could result in disability or in diseases such as cancer.

So biologists are keenly interested in identifying the accelerators that rev-up cell division. Ets transcription fact
'"/>

Source:Brown University


Page: 1 2

Related biology news :

1. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
2. Prions rapidly remodel good protein into bad, Brown study shows
3. Brown seaweed contains promising fat fighter, weight reducer
4. Brown scientists map structure of DNA-doctoring protein complex
5. Brown team finds crucial protein role in deadly prion spread
6. Bones in motion: Brown scientists to create new 3-D X-ray system
7. Viral DNA sequence a possible trigger for breast cancer
8. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
9. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
10. Columbia research lifts major hurdle to gene therapy for cancer
11. Combination therapy boosts effectiveness of telomere-directed cancer cell death
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brown cancer biologists identify major player cell growth

(Date:9/2/2014)... considered the most ideal source of nutrition for ... role in the evolution and civilizations of human ... a large number of bacterial species, including some ... no surprise to scientists and physicians. , Indeed, ... be the result of co-evolutionary and co-adaptive interactions ...
(Date:9/2/2014)... 2014 A study published in the September ... American Academy of Child and Adolescent Psychiatry ... psychiatric diagnosis had an increased risk of developing ... Using data from the nationwide Danish registers, a ... Nielsen, Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children ...
(Date:9/2/2014)... N.C. -- When you accidentally touch a hot oven, ... the basic neural circuits involved in sensing and responding ... the molecular players. , Duke researchers have made a ... involved in pain in worms, and have built a ... 2 in Nature Communications , may help direct ...
Breaking Biology News(10 mins):Are human breast milk microbiome 'neutral'? 2Are human breast milk microbiome 'neutral'? 3Risk of diabetes in children and adolescents exposed to antipsychotics 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3
... Department of Community Health (MDCH) has unveiled the ... includes significant recommendations developed from medical research conducted ... Eunice Kennedy Shriver National Institute for Child Health ... at the Wayne State University School of Medicine. ...
... press release is available in German . ... great happiness among inhabitants. On those days the air is ... difficult and unhealthy. According to the latest calculations of Max ... most of world population in 2050 if no counteractive measures ...
... Butterflies learn faster when a flower is rewarding than when ... when it comes to speed of learning with rewards. These ... Kandori and Takafumi Yamaki from Kinki University in Japan. Their ... Science of Nature , is the first to investigate and ...
Cached Biology News:State of Michigan adopts NIH's PRB progesterone therapy to combat infant mortality 2State of Michigan adopts NIH's PRB progesterone therapy to combat infant mortality 3Worldwide increase of air pollution 2Rewarding work for butterflies 2
(Date:9/2/2014)... 2014 Reportbuyer.com has added a new ... Products and Global Markets https://www.reportbuyer.com/product/1923022/Human-Reproductive-Technologies-Products-and-Global-Markets.html ... The objective of the study is to present ... reproductive technologies and products. Markets are divided according ... some markets are mature, while products in other ...
(Date:9/2/2014)... NEW PROVIDENCE, N.J. , Sept. 2, ... a corporate sponsor for MassBio,s 20th Annual Golf Classic, ... MassBioEd Foundation. The event will be held on September ... Plymouth, Massachusetts . The ... Massachusetts through educational programs, workforce development, ...
(Date:9/2/2014)... Ore. -- Scientists, including University of Oregon chemist ... create scaffolds of self-assembling, synthetic proteins called peptoid ... , The accomplishment -- detailed this week in ... the Proceedings of the National Academy of ... alternative design of the two-dimensional peptoid nanosheets that ...
(Date:9/2/2014)... , Sept. 2, 2014  Technology Applications International Corporation ... its wholly-owned subsidiary Renuell Int,l, Inc. has signed an ... Space Administration ("NASA") at the Johnson Space Center in ... See photos: tapplic.com/houstonphotos/ ... very pleased to announce our latest, exclusive agreement with ...
Breaking Biology Technology:Human Reproductive Technologies: Products and Global Markets 2Human Reproductive Technologies: Products and Global Markets 3Human Reproductive Technologies: Products and Global Markets 4Human Reproductive Technologies: Products and Global Markets 5Human Reproductive Technologies: Products and Global Markets 6Human Reproductive Technologies: Products and Global Markets 7Human Reproductive Technologies: Products and Global Markets 8Human Reproductive Technologies: Products and Global Markets 9Human Reproductive Technologies: Products and Global Markets 10Human Reproductive Technologies: Products and Global Markets 11Human Reproductive Technologies: Products and Global Markets 12Human Reproductive Technologies: Products and Global Markets 13Human Reproductive Technologies: Products and Global Markets 14Human Reproductive Technologies: Products and Global Markets 15Human Reproductive Technologies: Products and Global Markets 16Human Reproductive Technologies: Products and Global Markets 17Linde helps fund STEM education in Massachusetts 2Linde helps fund STEM education in Massachusetts 3UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 2Technology Applications International Corporation Subsidiary Enters Into Additional Exclusive Agreement with NASA at a Signing Ceremony at the Johnson Space Center In Houston, Texas 3
... dispute NimbleGen releases microarrays for DNA encyclopedia ... percent Icon Interactive lands animator as client ... managemenet Teklynx releases design software for UCC-compliant ... Benitec in contract dispute , Promega , an international ...
... In his new book The Art of the ... , Guy Kawasaki, a managing director of Garage Technology ... venture capital, most entrepreneurs would be better off spending ... relationships. , ,This is a good message, but ...
... will have a new resource to help them navigate ... related centers on campus. , ,The Office of Corporate ... , which is to include events, publications and both ... to UW=-Madison faculty, staff and students. , ,Were one ...
Cached Biology Technology:Tech Digest (11/10/2004) 2Sarcasm and rainmaking advice coexist in The Art of the Start 2Sarcasm and rainmaking advice coexist in The Art of the Start 3Sarcasm and rainmaking advice coexist in The Art of the Start 4Sarcasm and rainmaking advice coexist in The Art of the Start 5UW plans entrepreneurship program to link campus resources 2
Polyclonal Antibody to CLAN...
Request Info...
IRF7 Immunogen: Synthetic peptide corresponding to residues E(463) G T Q R E G V S S L D S S S(477) of human IRF7. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit polyclonal to TetR ( Abpromise for all tested applications). Antigen: Synthetic peptide: AQKLGVEQPTLYWHVKNKR, corresponding to amino acids 31 - 49 of TetR...
Biology Products: