Navigation Links
Breast tumors in mice eradicated using cancer vaccine

Findings could lead to new immune therapy for breast cancer

A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Cancer vaccines, which are more properly described as immunotherapy, work by boosting an immune response against tumor-associated antigens.

Using Listeria, the researchers, led by Yvonne Paterson, PhD, Professor of Microbiology, delivered the tumor-associated antigen HER-2/Neu to immune cells. HER-2/Neu is overexpressed in 20 to 40 percent of all breast cancers and also present in many cancers of the ovaries, lung, pancreas, and gastrointestinal tract. These cells eventually enlist killer T cells to seek out and destroy the tumor cells that display the HER-2/Neu molecule.

"We found that we can stop the tumor from growing out to 100 days, at which time we stopped measuring since this is a long time for experiments of this type," says Paterson. "The tumors stopped growing or went completely away." The researchers published their findings in the September 15 issue of the Journal of Immunology.

"The problem that we encounter is that often by the time a patient presents with cancer, they've developed immune tolerance to the tumor antigen, particularly when the antigen is expressed at low levels on normal tissue as with Her2/Neu," explains Paterson. "So how is the body to mount a strong enough immune reaction?"

In general, bacteria are good at inducing both innate and adaptive immune responses, activating such immune cells as macrophages, dendritic cells, and T cells. This helps jump-start the immune response to break tolerance.

But, why Listeria over other bacteria as a vehicle to deliver a tumor-associated antigen? Because of Listeria's unusual life style. Normally, when bacteria get taken up into an antigen-presenting cell, they are engulfed by a phagocytic vacuol
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
3. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
4. Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
5. New Breast Cancer Test Could Save Lives
6. Breast Cancer May Be Uniquely Sensitive To Inhibitors Of PI3K Pathway
7. Breast-Cancer Risk Linked to Exposure to Traffic Emissions at Menarche, First Birth
8. Nanoparticle Breast Cancer Drug Approved by FDA
9. Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer
10. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
11. Affymetrix and bioMerieux Extend Their Agreement on GeneChip(R) Technology to Breast Cancer Diagnostics

Post Your Comments:
(Date:11/4/2009)... GenVault Corporation, the leader in ambient tempe... medicine and identification, today announced that..., will be presenting at the BIOCOM Investor Confer...olla, CA. ,, During the presentation, Dr. Welli... with recent customer, technical and strategic dev...
(Date:11/4/2009)...ity of North Carolina at Chapel Hill School of Med...sco have developed and experimentally tested a tec... drugs. , The researchers developed a computatio...s of all known drugs are to the naturally occurrin...se targets within the cell. In a study published t...
(Date:11/3/2009)...s greatest wines are the result of a threefold syn...ng called the "terroir" -- a term often defined as...ts will discuss terroir with an emphasis on soil s...sburgh. "Terroir: Winegrapes and the Environment"... Meetings of the American Society of Agronomy (ASA...
Breaking Biology News(10 mins):GenVault Corporation to Present at the 2009 BIOCOM Investor Conference 2Study points to new uses, unexpected side effects of already existing drugs 2Great wines come from great soils 2Simcere Pharmaceutical Group Announces Collaboration with OSI Pharmaceuticals 5582 1Simcere Pharmaceutical Group Announces Collaboration with OSI Pharmaceuticals 5582 2Simcere Pharmaceutical Group Announces Collaboration with OSI Pharmaceuticals 5582 3Professional Pricing Society Announces Educational Partnership with Vendavo 26quot 3BPPS Accepting Vendavo Pricing Knowledge Series Awards to Cert 14536 1Professional Pricing Society Announces Educational Partnership with Vendavo 26quot 3BPPS Accepting Vendavo Pricing Knowledge Series Awards to Cert 14536 2Professional Pricing Society Announces Educational Partnership with Vendavo 26quot 3BPPS Accepting Vendavo Pricing Knowledge Series Awards to Cert 14536 3Professional Pricing Society Announces Educational Partnership with Vendavo 26quot 3BPPS Accepting Vendavo Pricing Knowledge Series Awards to Cert 14536 4Perspectives Ltd and Chicagoland Chamber of Commerce Partner to Promote Drug Free Workplaces EAP Provider Offers Workshops to Help Businesses Underst 59794 1Perspectives Ltd and Chicagoland Chamber of Commerce Partner to Promote Drug Free Workplaces EAP Provider Offers Workshops to Help Businesses Underst 59794 2Perspectives Ltd and Chicagoland Chamber of Commerce Partner to Promote Drug Free Workplaces EAP Provider Offers Workshops to Help Businesses Underst 59794 3
...gets identified by a Spanish research team may hol...disease. A new study published in Disease Models ... the cellular signals which cause one treatment fo... , One of the most devastating aspects of kidney f...imen. Normally, healthy kidneys take on the role ...
...lished in the open access journal PLoS Biology, ...gies to show the surprising result that the surviv...ers was similar, despite the presence of an extens...chers have used tags to follow larger ocean dwelle... and to follow migrations of mature salmon along m...
...Mich.---Wearing masks and using alcohol-based hand... by as much as 50 percent, a landmark new study su...icacy of non-pharmaceutical interventions in contr...setting, researchers at the University of Michigan...tudent subjects from seven U-M residence halls dur...
Other Biology News:Scientists identify cell changes leading to impaired 'artificial kidney' function 2Research challenges conventional notions about salmon survival 2Masks, hand washing, prevent spread of flu-like symptoms by up to 50 percent 2Masks, hand washing, prevent spread of flu-like symptoms by up to 50 percent 3
(Date:11/5/2009)..., Neb., Nov. 5 Transgeno...ed financial results for the quarter ended Septemb...resented in the tables that follow. ,, Third Q... of $366,000 or $0.01 per share for the third quar...or $0.01 per share for the third quarter of 2008. ...
(Date:11/5/2009)...WORTH, Texas, Nov. 5 Wou...d today that it has entered into a Letter of Inten...tual Health Technologies, Inc. (OTC Bulletin Board...000,000 in cash and debt, 4,000,000 shares of WNDM... WNDM on the Veriscrip technology being acquired f...
(Date:11/5/2009)...N, Texas, Nov. 5 SpineSmith Partne...Inc. to co-develop a unique scaffold that mimics t...g evaluation of several commercial products by Spi... company believes the GenOsteo scaffold represents...tes a unique and ideal environment for the deliver...
(Date:11/5/2009)... LASIK Surgery and vision correction...ctory were actively involved at the recently concl...Annual Meeting in San Francisco, California. Dr. S...r. Jonathan Davidorf, MD, Dr. Peter Rapoza, MD, Dr... R. Wayne Bowman, MD, Dr. Edward Manche, MD, and D...
Breaking Biology Technology:Transgenomic, Inc. Reports Third Quarter 2009 Results 2Transgenomic, Inc. Reports Third Quarter 2009 Results 3Transgenomic, Inc. Reports Third Quarter 2009 Results 4Transgenomic, Inc. Reports Third Quarter 2009 Results 5Transgenomic, Inc. Reports Third Quarter 2009 Results 6Transgenomic, Inc. Reports Third Quarter 2009 Results 7OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 2OTCBB-WNDM Announces LOI to Acquire VHGI Assets for $10 Million Cash/Stock 3SpineSmith Partners and GenOsteo Announce Collaborative Product Development Agreement 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 2Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 3Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 4Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 5Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 6Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 7Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 8Leading Vision Correction Experts in Trusted LASIK Surgeons Directory Educate Fellow Doctors at AAO Annual Meeting 9
...n beginning a brand new startup or building a smal...the challenges of attracting, and more importantly...ncentive for all employees to share in the wealth-... successful companies during the last fifteen year...as are being discussed and implemented by the Fort...
...always, these are general rules, and any good entr...nique. At the same time, in the last 3.5 years wev... performed about 750 basic reviews and about 100 d...d more than a dozen investments (and a couple misf...s, and a final reminder of why were doing this in ...
...nds to be used for labs, technology, research, com...tary Tommy G. Thompson today announced that the De...ilable an additional $1.4 billion to increase the ... respond to terrorism and other public health emer...lion, of which almost $16 Million will come from C...
Other Biology Technology:Learning from the Big Guys 2"For Angels Only...When to say No... 2"For Angels Only...When to say No... 3Wisconsin to Receive $25 Million for Bioterrorism 2
Rabbit Anti-Bacterial HISTIDASE Polyclonal Antibody, Unconjugated from AbD Serotec
Rabbit Anti-Human REDD1 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
Rabbit Anti-HAX1 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.
Goat Anti-Human FACTOR 8RELATED ANTIGEN Polyclonal Antibody, Unconjugated from AbD Serotec
Biology Products: