Navigation Links
Breakthrough developments in rheumatoid arthritis reported

ings with rheumatoid arthritis (and some family members without it) in an attempt to single out those genes that are involved in the autoimmune process. In fact, in 2004, they identified a gene called PTPN2 that confers a two-fold risk for rheumatoid arthritis and a number of other autoimmune diseases. The Feinstein now holds the largest collection from rheumatoid arthritis patients in the world.

Following the cellular pathway, it has been shown that PTPN22 influences the “trigger point” for activation of T-cells, immune cells that are normally called on to wage battle against infection. In autoimmune diseases like rheumatoid arthritis, PTPN22 appears to put people at higher risk of a wayward T-cell response.

The group has since gone on to use modern genetic methods to search for single nucleotide polymorphisms, or SNPs, to identify players that have fallen under the radar of older methods. The group has discovered another signaling molecule that seems to increase a person’s risk for rheumatoid arthritis by 30 percent. (The paper reporting the gene is in press.)

In collaborations with other scientists worldwide, Dr. Gregersen has also been able to show that certain markers are strongly linked to certain ethnic groups and others are not. “This will help us in figuring out what exactly is going on in this illness,” he said. “It’s pretty exciting.”

Early on in the rheumatoid arthritis research game, when HLA popped out as a major genetic player in the condition in the 1980s, Dr. Gregersen discovered that there was a shared bit of DNA that traveled in the disease. What took two years to identify in the laboratory – shared bands of genetic material – would take two days today. And that speed is what excites Dr. Gregersen. “We have the tools to get at these genes rather quickly now,” he said. “The more patients and controls that we have, the more power we will have to pull out new genes and make associations.”

I
'"/>

Source:North Shore-Long Island Jewish (LIJ) Health System


Page: 1 2 3 4

Related biology news :

1. Breakthrough Microarray-based Technology for the Study of Cancer
2. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
3. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
4. Breakthrough isolating embryo-quality stem cells from blood
5. Breakthrough System for Understanding Ocean Plant Life Announced
6. Breakthrough: Scientists create worlds tiniest organic particles
7. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
8. Sciences Breakthrough of the Year: Watching evolution in action
9. Breakthrough for stem cell research
10. Breakthrough in understanding type-2 diabetes as key genes identified
11. Breakthrough vaccine to treat chemo-resistant ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Breakthrough developments rheumatoid arthritis reported

(Date:8/21/2014)... AWI geologist Juliane Mller the Fram Strait is a key ... of this passage between Greenland and Svalbard warm Atlantic water ... the west side cold Arctic water masses and sea ice ... Atlantic. A considerable portion of the Atlantic water cools here ... layers. The circulation of the water caused in this manner ...
(Date:8/21/2014)... LAWRENCE A study recently published in the journal ... Kansas shows a new role for the protein adenomatous ... second-leading cause of cancer-related deaths in the U.S. , ... of Molecular Biosciences and co-leader of the Cancer Biology ... better part of her career trying to understand the ...
(Date:8/21/2014)... successfully replicated one of the crucial steps in photosynthesis, ... which could manufacture hydrogen as a fuel. , "Water ... exciting prospect to use them to create hydrogen, and ... from the ARC Centre of Excellence for Translational Photosynthesis ... offers potential as a zero-carbon replacement for petroleum products, ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Water and sunlight the formula for sustainable fuel 2
... UPTON, NY Hydrogen gas offers one of the ... But traditional methods of producing pure hydrogen face significant ... harmful carbon dioxide into the atmosphere or requiring rare ... scientists at the U.S. Department of Energy,s (DOE) Brookhaven ...
... press release is available in German . ... more,autonomy and far more freedom of discretion. Today, the ... a result of which KIT will be principal of ... future. In,addition, KIT will have the right to make ...
... rats demonstrates that the anti-epilepsy drug phenobarbital stunts neuronal ... first-line drug to treat epilepsy in human newborns. ... May 11, researchers at Georgetown University Medical Center (GUMC) ... pups about a week old changed the way the ...
Cached Biology News:Low-cost nanosheet catalyst discovered to split hydrogen from water 2Low-cost nanosheet catalyst discovered to split hydrogen from water 3Low-cost nanosheet catalyst discovered to split hydrogen from water 4More freedom of discretion for KIT 2Study raises questions about use of anti-epilepsy drugs in newborns 2Study raises questions about use of anti-epilepsy drugs in newborns 3
(Date:8/21/2014)... August 21, 2014 DNA vaccine pioneer ... in its development of JRC-LAMP-vax, an innovative and safe ... Phase IC studies began this month in Hawaii, moving ... fever. , The Japanese red cedar releases pollen that ... Japan. Mountain Cedar pollen wreaks similar havoc in Colorado, ...
(Date:8/21/2014)... August 21, 2014 His Majesty Willem-Alexander, ... , The Court of His Majesty Willem-Alexander, King of ... the Grand Opening of POET-DSM Advanced Biofuels’ Project LIBERTY ... 3. , The King will take part in the ... scheduled for 11 a.m.-12:20 p.m. and tour the plant. ...
(Date:8/21/2014)... OTC Markets Group Inc. ... company, on its approval to list on The ... the best marketplace for established U.S. and global ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO "We ... its growth strategy and achievement of this important ...
(Date:8/21/2014)... 2014 Gallus BioPharmaceuticals , ... and manufacturing organization (CMO) announced today that it ... oncology company focused on the development of innovative ... the anti-prostate specific membrane antigen (PSMA) monoclonal antibody ... Under the agreement the antibody will be produced ...
Breaking Biology Technology:Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... you played was Pac-Man, you might have missed the advances ... and leaders. , ,Three University of Wisconsin-Madison professors, among the ... games over traditional teaching tools Thursday evening. , ... in Madison by Accelerate Madison and WTN ...
... considers wireless bids ,The City of Madison received bids ... InSite Wireless to build wireless hotspots around the ... was Monday. The winning vendor will pay the city, county ... be able to charge access fees. Certain local sites could ...
... company that makes optical tests capable of quickly finding ... of its $5 million investment round. , ,OpGen, a ... sells its testing services to a variety of clients. ... service and new developments such as packaged instruments that ...
Cached Biology Technology:Games that make leaders: top researchers on the rise of play in business and education 2Games that make leaders: top researchers on the rise of play in business and education 3Games that make leaders: top researchers on the rise of play in business and education 4Tech Digest: Madison wireless, angels, Third Wave, Esker, Research Park 2OpGen completes $5 million investment round 2
... of samples may be carried out using this ... minimum operator attention. System control and data ... CE 4900. The elegant, powerful and very ... and Windows 98 and 2000., The supplied automatic ...
... ideal for routine binary separations. Excellent detection ... 4201 UV-Visible variable wavelength detector. Ultra-fine control ... two highly accurate and precise, high pressure ... pumps., Chromatograms may be plotted on a printer ...
...
... Human Raji cells were cultured in RPMI 1640 ... the log phase of growth. In order ... cells were fixed in acetone-methanol. The cells ... coated slide, with each wells surface specifically treated ...
Biology Products: