Navigation Links
Breakthrough developments in rheumatoid arthritis reported

ings with rheumatoid arthritis (and some family members without it) in an attempt to single out those genes that are involved in the autoimmune process. In fact, in 2004, they identified a gene called PTPN2 that confers a two-fold risk for rheumatoid arthritis and a number of other autoimmune diseases. The Feinstein now holds the largest collection from rheumatoid arthritis patients in the world.

Following the cellular pathway, it has been shown that PTPN22 influences the “trigger point” for activation of T-cells, immune cells that are normally called on to wage battle against infection. In autoimmune diseases like rheumatoid arthritis, PTPN22 appears to put people at higher risk of a wayward T-cell response.

The group has since gone on to use modern genetic methods to search for single nucleotide polymorphisms, or SNPs, to identify players that have fallen under the radar of older methods. The group has discovered another signaling molecule that seems to increase a person’s risk for rheumatoid arthritis by 30 percent. (The paper reporting the gene is in press.)

In collaborations with other scientists worldwide, Dr. Gregersen has also been able to show that certain markers are strongly linked to certain ethnic groups and others are not. “This will help us in figuring out what exactly is going on in this illness,” he said. “It’s pretty exciting.”

Early on in the rheumatoid arthritis research game, when HLA popped out as a major genetic player in the condition in the 1980s, Dr. Gregersen discovered that there was a shared bit of DNA that traveled in the disease. What took two years to identify in the laboratory – shared bands of genetic material – would take two days today. And that speed is what excites Dr. Gregersen. “We have the tools to get at these genes rather quickly now,” he said. “The more patients and controls that we have, the more power we will have to pull out new genes and make associations.”

I
'"/>

Source:North Shore-Long Island Jewish (LIJ) Health System


Page: 1 2 3 4

Related biology news :

1. Breakthrough Microarray-based Technology for the Study of Cancer
2. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
3. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
4. Breakthrough isolating embryo-quality stem cells from blood
5. Breakthrough System for Understanding Ocean Plant Life Announced
6. Breakthrough: Scientists create worlds tiniest organic particles
7. Breakthrough in micro-device fabrication combines biology and synthetic chemistry
8. Sciences Breakthrough of the Year: Watching evolution in action
9. Breakthrough for stem cell research
10. Breakthrough in understanding type-2 diabetes as key genes identified
11. Breakthrough vaccine to treat chemo-resistant ovarian cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Breakthrough developments rheumatoid arthritis reported

(Date:4/16/2014)... have identified a new syndrome called "osteosarcopenic obesity" that ... with obesity. , "It used to be the thinking ... would be because the bones were supporting more weight," ... at Florida State. "But, that,s only true to a ...
(Date:4/16/2014)... Nicolas Doucet of the Centre INRSInstitut Armand-Frappier has just received ... in the amount of nearly US$600,000. The 5-year grant is ... called RNases and to explore their biomedical potential in the ... , "Receiving a grant at this level is ...
(Date:4/16/2014)... a densely packed array of finger-like projections called ... line our intestines., Vanderbilt University researchers have now discovered ... critical for absorbing nutrients and defending against pathogens. The ... , reveal a role for adhesion molecules in brush ...
Breaking Biology News(10 mins):Researchers: Obesity can amplify bone and muscle loss 2High-level NIH grant goes to professor Nicolas Doucet of INRS 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 3
... rodents known as Murinae (mice, rats, etc.), which first ... the entire Old World (Eurasia, Africa, Australia) in less ... have long suspected that one of the reasons for ... apparatus. Now, researchers have used the brilliant X-ray beams ...
... beginning of October. The goal is to develop the production ... manufacture tires made from dandelion rubber. This is why molecular ... supplier built a pilot facility in Mnster that is capable ... time, they cultivate several hectares of a dandelion variety which ...
... bus, escaping a burning building or taking part in ... up knee problems for later in life, according to ... Journal of Biomedical Engineering and Technology . 9 ... fatigue, numbness and bunions when wearing such footwear. Despite ...
Cached Biology News:Chewing their way to success 2Fraunhofer and Continental come together when the dandelion rubber meets the road 2Fraunhofer and Continental come together when the dandelion rubber meets the road 3No running for the well-heeled 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... owners drew up their lists of New Year,s resolutions for 2014, ... my furry companion." Nowadays there are pet salons, dog and cat ... the little canine or feline darlings along wherever mommy or daddy ... toys at the pet store. But anyone who has ever lived ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... TIME: 8:30 a.m. Eastern Time HOST: Dr. Candace ... Kendle, Chairman and CEO, ... conference call and simultaneous webcast Oct. 31,at 8:30 a.m. Eastern Time to ... session will follow. (Logo: http://www.newscom.com/cgi-bin/prnh/20030429/KNDLLOGO ) Webcast Instructions ...
... Texas, Oct. 10 Luminex Corporation,(Nasdaq: LMNX ) ... on Wednesday, October 24, 2007. Results are scheduled for ... a conference call to discuss the operating,highlights and financial ... October 25, 2007, at 8:00 a.m. Eastern time. ...
... Campbell Alliance, the leading,management consulting firm specializing in ... was recognized as one of the best,places to work ... by the,Triangle Business Journal, ranking third among midsize companies. ... Business Journal,s annual Best,Places to Work luncheon and awards ...
Cached Biology Technology:Kendle Invites You to Attend Its Third Quarter 2007 Earnings Conference Call and Webcast 2Luminex Corporation Third Quarter Earnings Release Scheduled for October 24, 2007 2Luminex Corporation Third Quarter Earnings Release Scheduled for October 24, 2007 3Campbell Alliance Named 'Best Place to Work' by Triangle Business Journal 2
... a high quality whole genome sequencing service. ... costs allow even the smallest of laboratories ... key features which set our whole genome ... construction strategies, proprietary assembly software, rapid project ...
Great for biotinylating DNA/RNA probes...
... polyclonal antibody to human XAB2 (amino terminus) ... identified through its interaction with XPA. Immunoprecipitation ... of XAB2 interacts with the transcription-coupled repair-specific ... with RNA polymerase II. Microinjection experiments with ...
... maintenance, calibration, and validation (MCV) ... 96-well plate used for hands-free ... procedures using the Bio-Plex suspension ... is for use with Bio-Plex ...
Biology Products: