Navigation Links
Breakthrough: Scientists create world's tiniest organic particles

University of North Carolina at Chapel Hill chemists have developed what they believe is a breakthrough method of creating the world's tiniest manufactured particles for delivering drugs and other organic materials into the human body.Adapting technology pioneered by the electronics industry in fabricating transistors, the team has figured out for the first time how to create particles for carrying genetic material, pharmaceuticals and other compounds of unprecedented small size and uniformity. The tiny bits are so small they can be designed and constructed to measure only a hundred nanometers or so in diameter. A nanometer is a billionth of a meter.

Leading the group is Dr. Joseph M. DeSimone, William R. Kenan Jr. Distinguished professor of chemistry and chemical engineering at UNC and N.C. State University. A member of the UNC College of Arts and Sciences and the National Academy of Engineering, DeSimone also directs the National Science Foundation Science and Technology Center for Environmentally Responsible Solvents and Processes and the Institute for Advanced Materials, Nanoscience and Technology at UNC.

"Billions of dollars are being spent now on nanotechnology and nanoparticles, but 99 percent of the materials people are focusing on are metals and metal oxides, which are inorganic," DeSimone said. "Our method, which is really exciting, for the first time opens the world's door to marrying organic materials to nanotechnology. Biology, after all, is almost exclusively organic materials."We really believe this work will have a profound positive impact down the road on human health care. This includes, but is not limited to, chemotherapy, gene therapy, disease detection and drug delivery."

A report on the findings appeared online this morning (June 21) in the Journal of the American Chemical Society. Other authors -- all in chemistry at UNC -- are Drs. Jason P. Rolland and Ginger M. Denison, recent Ph.D. recipients; Drs. Benjamin W. Maynor and Larkin E. Euliss, postdoctoral fellows; and graduate student Ansley E. Exner.

Until now, DeSimone said, most current techniques for particle formation were incompatible with organic materials. That was because they involved baking, etching or processing robust metals and such with solvents that would have destroyed far more fragile organic matter such as genes or drugs.

The new method avoids harsh treatment but also allows formation of uniform particles in any shape designers choose ?spheres, rods, cones, trapezoidal solids, etc. -- and essentially any composition, he said. The relatively simple process, which he and colleagues are calling Particle Replication in Nonwetting Templates, or PRINT, also avoids creating films or "scum layers" that would clump particles together rather than allowing them to be harvested independent of one another."This is in contrast to traditional imprint lithography with silicon, glass or quartz molds where it is difficult to eliminate this residual material between objects," DeSimone said.

Particles injected into the body can be designed to be biodegradable, he said. Some are made from the same material used to make surgical sutures. They will incorporate as "cargo" whatever biological material designers want to get into patients' bloodstreams for more efficient uptake by cells for diagnostic testing or therapy.Studies with various organic compounds have been very successful, the chemist said. New studies with mice have recently begun at the UNC School of Medicine, which DeSimone joined as professor of pharmacology.

"The process starts off when we make a master template in a clean room at places like the Triangle National Lithography Center at N.C. State University," DeSimone said. "From that we make impressions with what we call liquid Teflon, and the resulting molds look something like ice cube trays with tiny cavities in them. After that, we mold the carrier and fragile functional materials into w hatever particles we want and gently wash them off the molds with buffer solutions into vials or other containers to concentrate them. Then they can be injected."

DeSimone, his colleagues, UNC and others have formed a new company, Liquidia Technologies Inc., with $2.5 million in angel funding and venture capital to further develop and commercialize the unique new technology. It is the second company for which DeSimone has been largely responsible.

The first was MiCell Technologies, which developed his research showing that it was possible to use carbon dioxide as a solvent in place of organic solvents, which polluted the environment.

"We are most excited about the commercial implications of Professor DeSimone's breakthrough with PRINT," said Dr. Lowry Caudill, chairman of Liquidia. "We believe that the PRINT process is an extremely versatile method that offers unparalleled uniformity and precision for making organic nanoparticles that will have profound implications in medicine and many other industries, including display technologies."Prior to this, no one else has fused the highly uniform and precise methods for fabricating transistors with the organic nanoparticle world," said Bruce Boucher, president of Liquidia. "It is truly a revolutionary discovery."


Source:University of North Carolina at Chapel Hill

Related biology news :

1. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
2. Scientists Replicate Hepatitis C Virus in Laboratory
3. Scientists detect probable genetic cause of some Parkinsons disease cases
4. Scientists find missing enzyme for tuberculosis iron scavenging pathway
5. Scientists seek answers on what activates deadly anthrax spores
6. Yale Scientists Find MicroRNA Regulates Ras Cancer Gene
7. Scientists collaborate to assess health of global environment
8. Scientists decipher genome of fungus that can cause life-threatening infections
9. Scientists discover the cellular roots of graying hair
10. Scientists rid stem cell culture of key animal cells
11. Scientists develop new color-coded test for protein folding
Post Your Comments:

(Date:11/12/2015)...  Arxspan has entered into an agreement with ... use of its ArxLab cloud-based suite of biological ... will support the institute,s efforts to electronically manage ... internally and with external collaborators. The ArxLab suite ... Institute,s electronic laboratory notebook, compound and assay registration, ...
(Date:11/10/2015)... Nov. 10, 2015 About ... that helps to identify and verify the identity ... considered as the secure and accurate method of ... a particular individual because each individual,s signature is ... especially when dynamic signature of an individual is ...
(Date:11/2/2015)... Nov. 2, 2015  SRI International has been awarded ... preclinical development services to the National Cancer Institute (NCI) ... provide scientific expertise, modern testing and support facilities, and ... pharmacology and toxicology studies to evaluate potential cancer prevention ... The PREVENT Cancer Drug Development Program is an NCI-supported ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... , November 27, 2015 ... Growing popularity of companion diagnostics is ... cancer biomarkers market with pharmaceutical companies and ... companion diagnostic tests. . ... Complete report on global cancer biomarkers ...
(Date:11/26/2015)... November 26, 2015 --> ... specializing in imaging technologies, announced today that it has received ... of the Horizon 2020 European Union Framework Programme for Research ... clinical trial in breast cancer. , --> ... --> --> The study aims ...
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... , November 25, 2015 Studies ... and human plaque and pave the way for more effective ... in cats     --> ... commonly diagnosed health problems in cats, yet relatively little was ... Two collaborative studies have been conducted by researchers from the ...
Breaking Biology Technology: