Navigation Links
Breaks in hibernation help fight bugs

A habit in some animals to periodically wake up while hibernating may be an evolutionary mechanism to fight bacterial infection, according to researchers at Penn State. The finding could offer an insight into the spread and emergence of infectious disease in wildlife, and has potential implications for human health.

Many warm-blooded animals slip into an inert sleep-like state as part of a unique strategy to get past harsh winters when food supplies are low and the need for energy to stay warm is high. The immune system is in sleep mode as well.

"The production of antibodies, and white blood cells is stopped. Basically all cell reproduction shuts off," says Angela Luis, a doctoral candidate in ecology at Penn State's Center for Infectious Disease Dynamics.

However, animals regularly snap out of their torpor, and become fully active. But such sudden breaks from slumber eat into much of the animal's stored energy reserves, and it is not fully clear why the animals need to wake up, and how often

Some scientists think the answer lies in bacterial infections that could run rampant in the face of an immune system that is essentially asleep.

"Animals cannot tell when they need to wake up, or if they are infected," says Luis. If the animals hibernate for long they risk serious infection, she says, while waking up frequently wastes precious energy, and could prove fatal as well.

In other words, animals with an optimal time of torpor will win out over others, says Luis, who presented her findings at the 91st annual meeting of the Ecological Society of America.

Luis and her colleagues used a simple mathematical model that mimicked the growth of bacteria such as E. coli and Salmonella in European ground squirrels, and how it affected their torpor patterns in relation to temperature.

Microbial growth depends on temperature. Most bacteria grow faster when it is warm and much slower when it is cold. For animals exposed to Salmonella, which multiplies rapidly in warm temperature, a regular break in hibernation would be an important adaptation to combat the germs, when experiencing a warmer winter. However, Salmonella doesn't thrive at very low temperatures, so when animals experience a particularly cold winter, these breaks wouldn't be crucial.

But if the animals were exposed to certain pathogens that thrive at low temperatures, like some E. coli, the animals would still have to regularly break their hibernation to ensure protection at all temperatures, Luis explains.

"Our model, which is confirmed by field data, shows that torpor patterns generally seen in some hibernating animals may be an evolutionary adaptation to help protect them from bacteria that grow well in low temperatures," says Luis.

The researchers suggest that an understanding of how pathogens interact with their hibernating hosts could provide valuable insight into the spread and emergence of zoonotic diseases.


'"/>

Source:Penn State


Related biology news :

1. Possible brain hormone may unlock mystery of hibernation
2. Learning to fight an adversary that wont stay down
3. Antibiotic might fight HIV-induced neurological problems
4. NYU study reveals how brains immune system fights viral encephalitis
5. Molecular models advance the fight against malaria
6. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
7. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Two chemicals boost immune cells ability to fight HIV without gene therapy
10. Experiment station researchers to explore genome of disease-fighting fungus
11. Bacterial genome sheds light on synthesizing cancer-fighting compounds
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2016)... SuperCom (NASDAQ:   SPCB ... e-Government, Public Safety, HealthCare, and Finance sectors announced today that Leaders ... to implement and deploy a community-based supportive services program to reduce ... , further expanding its presence in the state. ... This new program, which is expected ...
(Date:12/16/2016)... 16, 2016 Research and Markets has announced ... Global Forecast to 2021" report to their offering. ... The biometric vehicle access ... a CAGR of 14.06% from 2016 to 2021. The market is ... to reach 854.8 Million by 2021. The growth of the biometric ...
(Date:12/15/2016)... , Dec. 15, 2016 Advancements ... experience, health wellness and wellbeing (HWW), and ... in three new passenger vehicles begin to ... gesture recognition, heart beat monitoring, brain wave ... facial monitoring, and pulse detection. These will ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017   Pulmatrix, Inc . ... company developing innovative inhaled therapies to address serious pulmonary ... fungal infections in the lungs of CF patients, PUR1900, ... (QIDP) by the U.S. Food & Drug Administration. ... designed to speed the development of novel drugs against ...
(Date:1/17/2017)... , Jan. 17, 2017  Only nine percent of ... over profits, while only 16 percent believe health insurance ... today. Meanwhile, 36 percent of U.S. adults believe health ... over profits, compared to hospitals (23%). "We ... said Wendy Salomon , vice president of reputation ...
(Date:1/17/2017)... Jose, CA (PRWEB) , ... January 17, 2017 , ... ... cultivate a balanced, peaceful and healthy lifestyle, announced today the official launch of its ... and frees the mind. , In development for over a year, the ...
(Date:1/17/2017)... ... January 17, 2017 , ... Diagenode, a ... announced a collaboration with the Heidelberg University Hospital and the German Cancer Research ... following the company’s successful launch of its CATS (Capture and Amplification by ...
Breaking Biology Technology: