Navigation Links
Breaks in hibernation help fight bugs

A habit in some animals to periodically wake up while hibernating may be an evolutionary mechanism to fight bacterial infection, according to researchers at Penn State. The finding could offer an insight into the spread and emergence of infectious disease in wildlife, and has potential implications for human health.

Many warm-blooded animals slip into an inert sleep-like state as part of a unique strategy to get past harsh winters when food supplies are low and the need for energy to stay warm is high. The immune system is in sleep mode as well.

"The production of antibodies, and white blood cells is stopped. Basically all cell reproduction shuts off," says Angela Luis, a doctoral candidate in ecology at Penn State's Center for Infectious Disease Dynamics.

However, animals regularly snap out of their torpor, and become fully active. But such sudden breaks from slumber eat into much of the animal's stored energy reserves, and it is not fully clear why the animals need to wake up, and how often

Some scientists think the answer lies in bacterial infections that could run rampant in the face of an immune system that is essentially asleep.

"Animals cannot tell when they need to wake up, or if they are infected," says Luis. If the animals hibernate for long they risk serious infection, she says, while waking up frequently wastes precious energy, and could prove fatal as well.

In other words, animals with an optimal time of torpor will win out over others, says Luis, who presented her findings at the 91st annual meeting of the Ecological Society of America.

Luis and her colleagues used a simple mathematical model that mimicked the growth of bacteria such as E. coli and Salmonella in European ground squirrels, and how it affected their torpor patterns in relation to temperature.

Microbial growth depends on temperature. Most bacteria grow faster when it is warm and much slower when it is cold. For animals exposed to Salmonella, which multiplies rapidly in warm temperature, a regular break in hibernation would be an important adaptation to combat the germs, when experiencing a warmer winter. However, Salmonella doesn't thrive at very low temperatures, so when animals experience a particularly cold winter, these breaks wouldn't be crucial.

But if the animals were exposed to certain pathogens that thrive at low temperatures, like some E. coli, the animals would still have to regularly break their hibernation to ensure protection at all temperatures, Luis explains.

"Our model, which is confirmed by field data, shows that torpor patterns generally seen in some hibernating animals may be an evolutionary adaptation to help protect them from bacteria that grow well in low temperatures," says Luis.

The researchers suggest that an understanding of how pathogens interact with their hibernating hosts could provide valuable insight into the spread and emergence of zoonotic diseases.


Source:Penn State

Related biology news :

1. Possible brain hormone may unlock mystery of hibernation
2. Learning to fight an adversary that wont stay down
3. Antibiotic might fight HIV-induced neurological problems
4. NYU study reveals how brains immune system fights viral encephalitis
5. Molecular models advance the fight against malaria
6. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
7. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Two chemicals boost immune cells ability to fight HIV without gene therapy
10. Experiment station researchers to explore genome of disease-fighting fungus
11. Bacterial genome sheds light on synthesizing cancer-fighting compounds
Post Your Comments:

(Date:4/26/2016)... LONDON , April 26, 2016 ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... a partnership to integrate the Onegini mobile security ... (Logo: ) The ... enhanced security to access and transact across channels. ...
(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
(Date:6/23/2016)... 23, 2016   EpiBiome , a precision microbiome ... in debt financing from Silicon Valley Bank (SVB). The ... to advance its drug development efforts, as well as ... "SVB has been an incredible strategic partner to ... traditional bank would provide," said Dr. Aeron Tynes ...
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division of ... and optimized exclusively for Okuma CNC machining centers at The International Manufacturing Technology ... among several companies with expertise in toolholding, cutting tools, machining dynamics and distribution, ...
Breaking Biology Technology: