Navigation Links
Breaking the mold: Research teams sequence three fungus genomes

From garden compost to forest greenery, the mold Aspergillus fumigatus lurks across much of the world. And so does its impact. The most common mold causing infection, A. fumigatus triggers allergic reactions, asthma attacks--and even deadly infections among people with weakened immune systems.

Now, in the December 22 issue of the journal Nature, scientists at The Institute for Genomic Research (TIGR) and their collaborators report the mold's sequenced genome. The genome could lead researchers to A. fumigatus genes with the potential to generate better diagnostics and treatment for fungal infection. "This genome sequence is going to be central for developing tools for effectively managing A. fumigatus infections as they become more prevalent in the aging population," predicts first author William Nierman, a microbiologist at TIGR.

Nierman co-authored two additional Aspergillus genome papers in the same issue of Nature. One describes a genome project on Aspergillus oryzae, a nonpathogenic food industry workhorse that has produced sake (rice wine), miso (soybean paste), and shoyu (soy sauce) for 2,000 years. The third paper reports the genome sequence of model organism Aspergillus nidulans and compares the organism to A. oryzae and A. fumigatus. The work was carried out collaboratively at several institutions in the U.S., U.K., Spain, Japan, France, Brazil, Austria, Switzerland, and Germany. David Denning of the University of Manchester coordinated the projects.

Unlike most fungi, A. fumigatus likes it hot--and hotter. The fungus enjoys an unusual range of temperatures. At home in the compost heap, A. fumigatus tolerates temperatures up to 70 degrees Celsius. The fungus becomes a human pathogen because it's perfectly comfortable at body temperature, 37 degrees C. Altering ambient temperatures in the lab, TIGR scientists tracked gene activity, documenting different
'"/>

Source:The Institute for Genomic Research


Page: 1 2

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Researchers find how protein allows insects to detect and respond to pheromones
4. Researchers Uncover Key Step In Manufacture of Memory Protein
5. Research advances quest for HIV-1 vaccine
6. Research on Worms Yields Clues on Aging
7. Researchers reveal the infectious impact of salmon farms on wild salmon
8. Researchers identify target for cancer drugs
9. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
10. Researchers discover molecule that causes secondary stroke
11. Researchers find missing genes of ancient organism

Post Your Comments:
(Date:11/23/2009)...pplied mathematicians dissected the morphology of ...ristic long leaf with a saddle-like arc midsection...imple cause of the lily,s fan-like shapeelastic re...l growthwas revealed by using an equally simple te... a postdoctoral student at Harvard,s School of Eng...
(Date:11/23/2009)...that a common oral bacterium may exacerbate autoim..., "Unique Lipids from a Common Human Bacterium Rep...ncing Autoimmunity," appears in the December 2009 ...Multiple sclerosis (MS), a disease where the immun...s nearly 1 in 700 people in the United States. Pa...
(Date:11/23/2009)...and USDA study concluded that 50 million U.S. acre... could be converted from current uses to the produ...rom which biomass could be harvested for use as a ...of a perennial grass monoculture from which substa...s expected to require nitrogen fertilizer. , An ...
Breaking Biology News(10 mins):The cause behind the characteristic shape of a long leaf revealed 2Factors from common human bacteria may trigger multiple sclerosis 2Switchgrass produces biomass efficiently 2Repair ACL Injuries in Young Athletes Quickly 51663 1Repair ACL Injuries in Young Athletes Quickly 51663 2K State scientist receives grant from National Institutes of Health to research cataracts 51658 1K State scientist receives grant from National Institutes of Health to research cataracts 51658 2Smaller plants punch above their weight in the forest say Queens biologists 9259 1Smaller plants punch above their weight in the forest say Queens biologists 9259 2
... for assessing environmental contamination after o...ons where it doesn,t work and might produce false ...ic Institution (WHOI) has warned. , Private firm...ing long strands of absorbent polypropylene snares...ntamination of the seafloor in the wake of an oil ...
...lif.-- A naturally occurring molecule made by symb...nt for inflammatory bowel disease, according to sc.... , "Most people tend to think of bacteria as in...rkis K. Mazmanian, an assistant professor of biolo...otic relationship between "good" bacteria and thei...
... Oslo SEVEN pioneering scientists who have trans...e, neuroscience and astrophysics have become the f.... , The laureates were selected for their groundb...ur understanding of the unusual properties of matt... the human brain and the nature of quasars. , The...
Other Biology News:Marine chemist says 'not so fast' to quick oil detection method 2Getting better with a little help from our 'micro' friends 2Getting better with a little help from our 'micro' friends 3Names of inaugural Kavli Prize winners revealed 2Names of inaugural Kavli Prize winners revealed 3
(Date:11/23/2009)...re-FirstCall/--PDLBioPharma,Inc.(PDL)(Nasdaq: PDLI...,2009astheex-dividenddateforits$200millionspeciald...ntransactioncompletedonNovember2,2009.Thedividendw...dontherecorddate,December1,2009.NASDAQhassettheapp...ofcommonstockforpurposesoftheex-dividenddateonNove...
(Date:11/23/2009)...stCall/--NeogenCorporation(Nasdaq: NEOG )announced...,sBoardofDirectorsatthecompany,srecentannualmeetin...experienceinthefood,agriculture,andtradeindustries...aleconomicsatVirginiaTechUniversity.FromJanuary200...renegotiatorwiththerankofambassador. ,, "Sinceo...
(Date:11/23/2009)...esignC or p.(IDC)announcedtodaythatDr.BruceL.A.Car...ccessfultrackrec or dinbiotechnologyexecutivemanag...enetics,inSeattle,WAandChiefScientificOfficeratNov...//www.newscom.com/cgi-bin/prnh/20091123/SF15228 ) ...fficercommented,"IamdelightedtowelcomeDr.BruceCart...
(Date:11/23/2009)...re/--Frost&Sullivan,theGrowthPartnershipCompan...shipandinnovationThursday,November19,2009attheExce...Antonio,Texas. ,, (Logo: http://www.newscom.com...eInnovationAwardsaregiventocompaniesthathavemadeas...healthcare.Suchcompanieshaveshownsuccessatmeetingt...
Breaking Biology Technology:PDL BioPharma Announces Ex-Dividend Date of November 27 for Special Dividend 2Richard T. Crowder Joins Neogen's Board of Directors 2Immune Design Corp. Announces Appointment of Dr. Bruce L.A. Carter as Executive Chairman and Director 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 3
...Dr. DAVID HARDY, TO DISCUSS CLINICAL USE OF THE, T...WITH THE THIRD QUARTER 2008 FINANC... Calif., Oct. 23 Monogram,Biosciences, Inc., (Nas...nce,call on Monday, October 27, 2008 at 4:30 p.m. ...gram,s Trofile(TM) Assay in conjunction with Pfize...
...echne Corporation,(Nasdaq: TECH ) announced today...dividend of $0.25 per share for the quarter ended ... payable November 17, 2008 to all common,sharehold...nd, Techne Corporation,s Chairman and Chief Execut...that the Board has decided to,pay this dividend. A...
...swire-FirstCall/ - Oncolytics Biotech Inc. (TSX:,O... entitled "Phase I Trial,of Oncolytic Reovirus (RE...xel in Patients with Advanced Solid Cancers" will ... Journal of Immunotherapy,the official journal of ...f,Cancer (iSBTc). The principal investigator for t...
Other Biology Technology:Monogram Announces Conference Call 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Paclitaxel/Carboplatin Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators to Present Combination REOLYSIN(R) and Paclitaxel/Carboplatin Results at iSBTc Annual Meeting 3
50 ml Magnetic Separation Rack from New England Biolabs
TOPO Shotgun Subcloning Kit from Invitrogen
Gtporator (4 ml) from GEN-TREND s.r.o.
Apoptosis Sampler Kit from Cell Signaling Technology
Biology Products: