Navigation Links
Brain's white matter -- More 'talkative' than once thought

Johns Hopkins scientists have discovered to their surprise that nerves in the mammalian brain’s white matter do more than just ferry information between different brain regions, but in fact process information the way gray matter cells do.

The discovery in mouse cells, outlined in the cover story of the March issue of Nature Neuroscience, shows that brain cells “talk?with each other in more ways than previously thought.

“We were surprised to see these nerve axons talking to other cells in the white matter,?says Dwight Bergles, Ph.D., an associate professor of neuroscience at Hopkins.

The discovery focuses on oligodendrocyte precursor cells (OPCs), whose main role when they mature into oligodendrocytes is to wrap themselves around and insulate nerves with a whitish coat of protective myelin. The immature cells simply hang around and divide very slowly, waiting to be spurred into action.

To learn more about OPCs that reside in the brain’s white matter, the Johns Hopkins researchers measured activity from individual precursor cells in the corpus callosum, a region of white matter that connects the two brain hemispheres. To their surprise, OPCs were found to have electrical signals produced by the neurotransmitter glutamate, similar to the signals used as the principle means of cell-to-cell communication and information processing in the gray matter. The phenomenon was unlikely, they said, because in the mouse brain, OPCs in the myelin-rich white matter are far from synapses, the points of contact between nerves where glutamate is released.

Theorizing that OPCs might have experienced glutamate in some less obvious way in this area of the brain, Bergles and his team studied nearby nerve cells to figure out where the glutamate might be coming from.

By forcing single nerve cells to become excited one at a time, they discovered that as electrical impulses are carried along the nerves, glutamate is released and caus
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Shifty-eyed Monkeys Offer Window Into Brains Social Reflexes
3. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
4. Brains own cannabis compound protects against inflammation
5. Brains gambling circuitry identified
6. Brains reward circuit activity ebbs and flows with a womans hormonal cycle
7. Why do aneurysms form? New studies suggest leading role for white blood cells
8. Bad enzymes may wear white hats after stroke
9. Gene patterns in white blood cells quickly diagnose disease
10. Research could lead to better drugs and whiter whites
11. For Pacific white shrimp, gender matters when competing for food
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain white matter More talkative than once thought

(Date:9/17/2014)... Biomedical Informatics at IMIM (Hospital del Mar Medical Research ... have recently published a study in eLife ... role in the evolution of new proteins, some of ... discovered., Ribosomes produce proteins from the instructions found in ... genome is RNA containing information for the synthesis of ...
(Date:9/17/2014)... Mutations in the human retinoblastoma protein gene are ... University scientists have turned to fruit fly eyes to ... , In a paper featured on the cover of ... Chemistry , Michigan State University researchers provide the first ... those present in the human cancer gene, said Irina ...
(Date:9/17/2014)... R.I. [Brown University] After decades of decline, grasses ... saltmarshes. To the eye, the marsh in those places ... that a key service of the marsh coastal ... back but the ecosystem function hasn,t come back," said ... senior author of the study in the journal ...
Breaking Biology News(10 mins):Parts of genome without a known function may play a key role in the birth of new proteins 2Abnormal properties of cancer protein revealed in fly eyes 2Cape Cod saltmarsh recovery looks good, falls short 2Cape Cod saltmarsh recovery looks good, falls short 3
... of Minnesota researchers are a key step closer to making ... funded by a $2.2 million United States Department of Energy ... in January, made the critical step by figuring out how ... the bacteria into ketones, which can be cracked to make ...
... ID An a l ... risk management, today announced the addition of three senior executives ... Steven Seoane has joined the company as vice president of ... Rando as director of analytics. Seoane, Barr and Rando bring ...
... of Wisconsin-Madison limnologist Stephen Carpenter has been awarded ... prestigious award for water-related activities, it was announced ... The award, which comes with $150,000 and a ... "whose work contributes broadly to the conservation and ...
Cached Biology News:U of M researchers close in on technology for making renewable petroleum 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 2ID Analytics Strengthens Management Team With Appointment of Senior Executives 3UW-Madison lake scientist gets world's top water prize 2
(Date:9/18/2014)... 2014   Sigma-Aldrich Corporation (Nasdaq: ... into a new gene editing partnership with the ... Under the partnership, Sigma-Aldrich will provide the Vector ... and dedicated gene editing bioinformaticians. The ... at the U-M Medical School. One initiative already ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
(Date:9/18/2014)... new microscopy technology that allows them to view ... , Dubbed "Complementation Activated Light Microscopy" (CALM), the ... order of magnitude finer than conventional optical microscopy, ... at the nanometer scale. , In a paper ... , the researchers behind CALM used it to ...
(Date:9/18/2014)... California (PRWEB) September 18, 2014 Silicon-valley ... forces with Digitaliza TXT , the latest addition ... to its Clinical Research Organization (CRO) Program, Clinovo further ... “After three days of ClinCapture training, we are now ... TXT CEO Ana Pulido. “We can also rely on ...
Breaking Biology Technology:Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3Scientists pioneer microscopy technique that yields fresh data on muscular dystrophy 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3
... August 28 XTL Biopharmaceuticals,Ltd. (NASDAQ: XTLB ... in the acquisition, development and commercialization of,therapeutics for ... and hepatitis C, today announced the receipt on ... indicating that, according to the,Company,s financial statements for ...
... to the NASDAQ Capital Market, NEW YORK, ... ; LSE: XTL; TASE: XTL), a biopharmaceutical company,engaged ... the treatment of unmet medical needs, particularly,neuropathic pain ... August 23,2007, of a NASDAQ Staff Deficiency Letter ...
... CITY, Aug. 27 ARUP Laboratories, a national,clinical ... in,innovative laboratory research and development, announced today that ... Premier Purchasing,Partners, L.P., one of the nation,s largest ... The agreement extends a previous,contract between ARUP and ...
Cached Biology Technology:XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 2XTL Receives Staff Letter From NASDAQ; XTL may Transfer its ADR Listing to the NASDAQ Capital Market 3XTL Receives Staff Letter From NASDAQ 2XTL Receives Staff Letter From NASDAQ 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
... Mouse L1210 cells were cultured in DMEM and ... In order to keep the antigens in their ... The cells are arrayed on a 12-well (5 ... specifically treated to enhance cellular attachment and to ...
... P815 cells were cultured in DMEM and harvested ... order to keep the antigens in their native ... cells are arrayed on a 12-well (5 mm) ... treated to enhance cellular attachment and to minimize ...
...
Screening assay to detect the Listeria monocytogenes in food samples by,DNA amplification and molecular hybridization on a microtiter plate....
Biology Products: