Navigation Links
Brain's own cannabis compound protects against inflammation

Some clinical studies have indicated that marijuana or its active cannabinoid ingredient alleviates symptoms of the inflammatory disease multiple sclerosis (MS). Also, researchers have found that the brain's natural "endocannabinoids" are released after brain injury and are believed to alleviate neuronal damage. However, scientists have not understood how such substances act within the brain's own immune system.

Now, experiments by Oliver Ullrich and colleagues have pinpointed how one of the brain's endocannabinoids protects neurons from inflammation after such damage. They say their studies could lead to new drugs to treat the inflammation and brain degeneration from MS or other such disorders.

In an article in the January 5, 2006, issue of Neuron, the researchers reported experiments showing how the endocannabinoid anandamide (AEA) protects brain cells from inflammation. Such a role in the brain's immune system is distinct from cannabinoids' effects on neuronal signaling that produce the behavioral effects of marijuana.

When Ullrich and colleagues analyzed brain tissue from people with MS, they found elevated levels of AEA, compared to healthy tissue. And in studies with mouse brain slices, they found that inducing damage with a brain-cell-exciting chemical, called NMDA, caused an invasion of the brain's immune cells, called microglia, and an increase in AEA levels.

Importantly, they found that adding AEA to such damaged brain tissue abolished inflammatory damage to the brain cells, but did not reduce the primary "excitotoxic" damage from the chemical. They found similar effects of AEA when they damaged the brain tissue by depriving it of oxygen and glucose.

The researchers also found that when they used a drug to block the receptors on microglial cells by which AEA effects the cells, inflammatory damage was increased.

The researchers also explored the mechanism by which AEA prevents inflammatory damage. They found th
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Shifty-eyed Monkeys Offer Window Into Brains Social Reflexes
3. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
4. Brains gambling circuitry identified
5. Brains reward circuit activity ebbs and flows with a womans hormonal cycle
6. Brains white matter -- More talkative than once thought
7. Endocannabinoids ?the brains cannabis ?demonstrate novel modes of action to stress
8. Researchers discover chemical compounds that affect plant growth
9. Bacterial genome sheds light on synthesizing cancer-fighting compounds
10. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
11. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Brain own cannabis compound protects against inflammation

(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
(Date:3/20/2015)... and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has announced the ... Report" report to their offering. This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... be enough to cool a hot temper, at least for a ... people who drank a glass of lemonade sweetened with sugar acted ... people who consumed lemonade with a sugar substitute. Researchers believe ... found in the bloodstream that provides energy for the brain. ...
... shows that anti-microbial medications are a common cause of ... (ALF), with women and minorities disproportionately affected. While ALF ... is unlikely; however liver transplantation offers an excellent survival ... published in the December issue of Hepatology , ...
... Washington, D.C. - U.S Energy Secretary Steven Chu today ... time to 57 innovative research projects - using computer ... would be impossible or impractical in the natural world. ... equal to 135,000 quad-core laptops, the research could, for ...
Cached Biology News:Researchers find link between sugar, diabetes and aggression 2Researchers find link between sugar, diabetes and aggression 3Researchers find link between sugar, diabetes and aggression 4Study finds anti-microbials a common cause of drug-induced liver injury and failure 2Could 135,000 laptops help solve the energy challenge? 2Could 135,000 laptops help solve the energy challenge? 3Could 135,000 laptops help solve the energy challenge? 4
(Date:5/5/2015)... N.J. , May 5, 2015 Roka Bioscience, ... on providing advanced testing solutions for the detection of foodborne ... present at the Bank of America Merrill Lynch 2015 Health ... will be held at Encore at the Wynn, ... webcast of the presentation will be available through the investor ...
(Date:5/5/2015)... 05, 2015 Research and Markets ... addition of the "Separation Systems Market ... Macromolecules which include protein, RNA, ... are broken into smaller molecules, during production ... requires various advanced systems like centrifugation, liquid ...
(Date:5/5/2015)... 2015  Renova™ Therapeutics, a biopharmaceutical company developing ... other chronic diseases, has engaged RAND Health Advisory ... reflect the healthcare patterns of multiple advanced heart ... used to characterize the impact the company,s lead ... groups of patients and the overall health care ...
(Date:5/5/2015)... BELLINGHAM, Washington, and WASHINGTON, D.C., USA (PRWEB) May 05, ... today on U.S. export regulations covering a wide range ... the industry say are hampering global competitiveness of U.S. ... will host a webinar on 12 May ... Category XII, which governs the commodities covered by International ...
Breaking Biology Technology:Global Separation Systems Market in Biotechnology 2015-2019 - Trends and Forecasts for the $28 Billion Market 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Comments needed now from photonics industry on revisions of U.S. export rules 2Comments needed now from photonics industry on revisions of U.S. export rules 3Comments needed now from photonics industry on revisions of U.S. export rules 4
... out beyond the horizon. Even as you read this, ... waterways and oceans, not to mention innumerable smaller merchant craft, ... out crews and cargos, and steaming from one location to ... a very murky world of shadowy ship registry offices, lengthy ...
... public health: Bioengineering researchers from the EPFL in Lausanne, ... deliver vaccines more effectively, with fewer side effects, and ... technologies. , Described in an article appearing online ... delivery platform is a deceptively simple combination of nanotechnology ...
... successful treatment can be. Therefore, the development of new ... small step is of great importance. In an article ... University researchers describe a technique that the journal regards as ... tissues, and our knowledge of the human genome also entails ...
Cached Biology Technology:Out beyond the horizon 2Out beyond the horizon 3New nanoparticle vaccine is more effective but less expensive 2New nanoparticle vaccine is more effective but less expensive 3