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Brain size may depend upon how neural cells are cleaved

t how its signaling determines the orientation of spindles during mitosis, and thus the orientation of cell cleavage.

"While this is basic research, we do know that this mechanism is very important in determining the ultimate size of the brain," said Tsai. "And, there are humans born with too few neurons, called microcephaly, or too many neurons, called macrocephaly. I would speculate that many of these cases are the outcome of some sort of impairment in the regulation of cell division, perhaps in the plane of division," said Tsai.

"And with the possibility that neural stem cells may find therapeutic use, the role of G protein signaling in the differentiation of such progenitor cells is going to be a very exciting area to explore," she said.


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Source:Howard Hughes Medical Institute


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